2.3.1.199: very-long-chain 3-oxoacyl-CoA synthase

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For detailed information about very-long-chain 3-oxoacyl-CoA synthase, go to the full flat file.

Reaction

Synonyms

3-ketoacyl CoA synthase, 3-ketoacyl-CoA synthase, acyl-CoA elongase, At1g01120, At2g26640, beta-ketoacyl CoA synthase, beta-ketoacyl-CoA synthase, Cer-zh, CER2-LIKE1, CER2-LIKE2, CER26, CER26L, CER6, CER60, condensing enzyme, Cut1, CUT1L, EC 2.3.1.119, ECERIFERUM 26, ECERIFERUM 26-like, ELO, ELo1, Elo1p, Elo2p, Elo3p, EloA, ELOVL1, ELOVL5, Elovl6, ELOVL7, FA elongase, FAE1, FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS, Fatty acid elongase, fatty acid elongase 1, fatty acid elongation 1, fatty acid elongation1, KCS, Kcs1, KCS17, KCS2, KCS2/DAISY, KCS20, MALCE1, microsomal fatty acid elongase, Onion2, Os03g0220100, Os10 g0416200, seed-specific condensing enzyme, very-long-chain fatty acid condensing enzyme, very-long-chain fatty acid-condensing enzyme, VLCFA condensing enzyme, VLCFA elongase, WSL4

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

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Results	in table
2	Activating Compound
19614	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Cofactor
138	Disease/ Diagnostics
11	Expression
27	General Information
6	IC50 Value
7	Inhibitors
6	KM Value [mM]
11	Localization
1	Metals/Ions
7	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
37	Organism
16	Pathway
2	PDB ID
2	pH Optimum
1	pI Value
1	Posttranslational Modification
17	Protein Variants
3	Purification (Commentary)
1	Reaction
32	Reference
1	Renatured (Commentary)
48	Source Tissue
52	Substrates and Products (Substrate)
6	Subunits
95	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Activating Compound

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Activating Compound on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADPH

Homo sapiens

Q9H5J4

ELOVL6 activity in membrane fractions is enhanced in the presence of NADPH

737127

additional information

Homo sapiens

Q9H5J4

the 3-ketoacyl-CoA reductase, KAR, the enzyme catalyzing the next step in metabolism after fatty acid elongase ELOVL6, largely stimulates ELOVL6 activity. Activity of purified enzyme ELOVL6 is enhanced by about 3fold in the presence of 3-ketoacyl-CoA reductase, KAR. This effect is KAR enzyme activity-independent, since it is observed in the absence of NADPH and in the poorly active or inactive KAR mutants, overview. ELOVL6 enzyme activity is also enhanced in a KAR enzyme activity-dependent manner

737127

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