2.3.1.199: very-long-chain 3-oxoacyl-CoA synthase
This is an abbreviated version!
For detailed information about very-long-chain 3-oxoacyl-CoA synthase, go to the full flat file.
Word Map on EC 2.3.1.199
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2.3.1.199
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vlcfas
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polyunsaturated
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acyl-coas
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desaturase
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elovls
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monounsaturated
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cuticular
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ceramide
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erucic
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pufas
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sphingolipids
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stearoyl-coa
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oilseed
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epicuticular
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adrenoleukodystrophy
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eicosenoic
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delta6
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docosapentaenoic
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napins
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vlc-pufas
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leek
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suberins
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medicine
- 2.3.1.199
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vlcfas
-
polyunsaturated
- acyl-coas
-
desaturase
-
elovls
-
monounsaturated
- cuticular
- ceramide
-
erucic
-
pufas
- sphingolipids
- stearoyl-coa
-
oilseed
-
epicuticular
- adrenoleukodystrophy
-
eicosenoic
-
delta6
-
docosapentaenoic
-
napins
-
vlc-pufas
- leek
- suberins
- medicine
Reaction
Synonyms
3-ketoacyl CoA synthase, 3-ketoacyl-CoA synthase, acyl-CoA elongase, At1g01120, At2g26640, beta-ketoacyl CoA synthase, beta-ketoacyl-CoA synthase, Cer-zh, CER2-LIKE1, CER2-LIKE2, CER26, CER26L, CER6, CER60, condensing enzyme, Cut1, CUT1L, EC 2.3.1.119, ECERIFERUM 26, ECERIFERUM 26-like, ELO, ELo1, Elo1p, Elo2p, Elo3p, EloA, ELOVL1, ELOVL5, Elovl6, ELOVL7, FA elongase, FAE1, FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS, Fatty acid elongase, fatty acid elongase 1, fatty acid elongation 1, fatty acid elongation1, KCS, Kcs1, KCS17, KCS2, KCS2/DAISY, KCS20, MALCE1, microsomal fatty acid elongase, Onion2, Os03g0220100, Os10 g0416200, seed-specific condensing enzyme, very-long-chain fatty acid condensing enzyme, very-long-chain fatty acid-condensing enzyme, VLCFA condensing enzyme, VLCFA elongase, WSL4
ECTree
2.3.1.199 very-long-chain 3-oxoacyl-CoA synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(9Z,12Z)-octadec-9,12-dienoyl-CoA + malonyl-CoA
(11Z,14Z)-3-oxoeicosa-11,14-dienoyl-CoA + CO2 + coenzyme A
(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-CoA + malonyl-CoA
(11Z,14Z,17Z)-3-oxoeicosa-11,14,17-trienoyl-CoA + CO2 + coenzyme A
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + coenzyme A
-
-
-
?
oleoyl-CoA + malonyl-CoA
?
-
in contrast to stearic acid-CoA, oleic acid-CoA serves as a less suitable substrate for elongation
-
-
?
oleoyl-CoA + malonyl-CoA
CoA + 3-oxo-eicosenoyl-CoA + 3-oxo-erucoyl-CoA + CO2
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preferred substrate
3-oxo-eicosenoyl-CoA is the major product
-
?
stearoyl-CoA + malonyl-CoA
CoA + 3-oxo-eicosanoyl-CoA + CO2
-
-
major product
-
?
(9Z)-hexadec-9-enoyl-CoA + malonyl-CoA
(11Z)-3-oxooctadec-11-enoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z)-hexadec-9-enoyl-CoA + malonyl-CoA
(11Z)-3-oxooctadec-11-enoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z,12Z)-octadec-9,12-dienoyl-CoA + malonyl-CoA
(11Z,14Z)-3-oxoeicosa-11,14-dienoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z,12Z)-octadec-9,12-dienoyl-CoA + malonyl-CoA
(11Z,14Z)-3-oxoeicosa-11,14-dienoyl-CoA + CO2 + coenzyme A
-
-
-
ir
(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-CoA + malonyl-CoA
(11Z,14Z,17Z)-3-oxoeicosa-11,14,17-trienoyl-CoA + CO2 + coenzyme A
-
-
-
?
(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl-CoA + malonyl-CoA
(11Z,14Z,17Z)-3-oxoeicosa-11,14,17-trienoyl-CoA + CO2 + coenzyme A
-
-
-
?
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
-
-
-
-
?
a very-long-chain acyl-CoA + malonyl-CoA
a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
-
-
-
?
arachidoyl-CoA + malonyl-CoA
?
-
25% activity compared to oleoyl-CoA
-
-
?
stearoyl-CoA + malonyl-CoA
?
-
best substrate for At2g26640 and FAE1
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
very-long-chain acyl-CoA + malonyl-CoA
CoA + very-long-chain 3-oxoacyl-CoA + CO2
-
-
-
-
?
additional information
?
-
-
At1g01120 (KCS1) and At2g26640 have broad substrate specificities when assayed with saturated and monounsaturated C16 to C24 acyl-CoAs while At4g34510 is specific for saturated fatty acyl-CoA substrates. KCS1 is most active with palmitic acid, palmitoleic acid, stearic acid, and arachidic acid but has very little activity with oleic acid and acyl chains longer than C20. At4g34510 is specific for saturated acyl-CoAs up to C22. FAE1 uses palmitic acid, palmitoleic acid, stearic acid, oleic acid, arachidic acid, 20:1, behenic acid, erucic acid, and lignoceric acid as substratesis and is specific for acyl-CoAs of 16 and 18 carbons in length
-
-
?
additional information
?
-
-
the enzyme shows highest activity towards saturated and monounsaturated C16 and C18. In the absence of an acyl-CoA substrate, the enzyme is unable to carry out decarboxylation of malonyl-CoA
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-
?
additional information
?
-
-
the enzyme shows no activity with polyunsaturated linoleic acid and alpha-linolenic acid and little or no activity with acyl-CoAs having 22 carbons or longer in chain length
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-
?
additional information
?
-
the effect of CER2-LIKE1 and CER2-LIKE2 proteins on fatty acid elongation is limited to specific condensing enzyme partners, and CER2-LIKE proteins either have their own unique substrate specificity, or a unique effect on the substrate specificity of the condensing enzyme with which they function
-
-
?
additional information
?
-
the effect of CER2-LIKE1 and CER2-LIKE2 proteins on fatty acid elongation is limited to specific condensing enzyme partners, and CER2-LIKE proteins either have their own unique substrate specificity, or a unique effect on the substrate specificity of the condensing enzyme with which they function
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-
?
additional information
?
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almost no activity with palmitic acid and 17:1DELTA9
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-
?
additional information
?
-
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almost no activity with palmitic acid and 17:1DELTA9
-
-
?
additional information
?
-
almost no activity with palmitic acid and 17:1DELTA9
-
-
?
additional information
?
-
the enzyme is able to elongate the C16-acyl-CoA up to C26-acyl-CoA
-
-
?
additional information
?
-
-
the enzyme is able to elongate the C16-acyl-CoA up to C26-acyl-CoA
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-
?
additional information
?
-
no activity with saturated and unsaturated fatty acids longer than C16
-
-
?
additional information
?
-
-
the enzyme is specific for acyl chain lengths between 16 and 20 carbons
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-
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