2.3.1.208: 4-hydroxycoumarin synthase This is an abbreviated version! For detailed information about 4-hydroxycoumarin synthase, go to the full flat file .
Reaction
malonyl-CoA +
2-hydroxybenzoyl-CoA =
2 CoA
+
4-Hydroxycoumarin +
CO2
Synonyms biphenyl synthase, BIS, BIS1, BIS2, BIS3, More
ECTree
Systematic Name
Systematic Name on EC 2.3.1.208 - 4-hydroxycoumarin synthase
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malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1].