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2.3.1.208: 4-hydroxycoumarin synthase

This is an abbreviated version!
For detailed information about 4-hydroxycoumarin synthase, go to the full flat file.

Reaction

malonyl-CoA
+
2-hydroxybenzoyl-CoA
= 2 CoA +
4-Hydroxycoumarin
+
CO2

Synonyms

biphenyl synthase, BIS, BIS1, BIS2, BIS3, More

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.208 4-hydroxycoumarin synthase

Systematic Name

Systematic Name on EC 2.3.1.208 - 4-hydroxycoumarin synthase

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SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1].