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2.3.1.219: demethoxycurcumin synthase

This is an abbreviated version!
For detailed information about demethoxycurcumin synthase, go to the full flat file.

Reaction

4-coumaroyl-CoA
+
(4-coumaroyl)acetyl-CoA
+
H2O
= 2 CoA +
bisdemethoxycurcumin
+
CO2

Synonyms

curcumin synthase, CURS, CURS1, CURS2, CURS3, ZoCURS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.219 demethoxycurcumin synthase

Systematic Name

Systematic Name on EC 2.3.1.219 - demethoxycurcumin synthase

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SYSTEMATIC NAME
IUBMB Comments
4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming)
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1].