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2.3.1.225: protein S-acyltransferase

This is an abbreviated version!
For detailed information about protein S-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.225

Reaction

palmitoyl-CoA
+
[protein]-L-cysteine
=
[protein]-S-palmitoyl-L-cysteine
 +
CoA

Synonyms

Akr1, Akr1p, APT1, Asp-His-His-Cys motif palmitoyl transferase, At3g51390, DHHC palmitoyl transferase, DHHC protein, DHHC protein acyltransferase, DHHC-2, DHHC-21, DHHC-21 palmitoyl transferase, DHHC-3, DHHC-3 palmitoyl transferase, DHHC-7, DHHC-8, DHHC-CRD S-acyltransferase, DHHC16, DHHC17, DHHC2, DHHC3, DHHC4, DHHC5, Erf2, Erf2p, G-protein palmitoyltransferase, HIP14, palmitoyl acyltransferase, Pat, PAT10, PAT14, PAT15, PAT21, PAT24, PAT4, Pfa3, Pfa4, PFA5, protein acyl transferase, protein acyltransferase, protein S-acyl transferase 4, Ras PAT, S-protein acyltransferase, SEC18p, Swf1, ZDHHC3, ZDHHC5

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.225 protein S-acyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.225 - protein S-acyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
myristoyl-CoA + [Gialpha1]-L-cysteine
[protein]-S-myristoyl-L-cysteine + CoA
show the reaction diagram
-
GiR1 is myristoylated at its N-terminus and palmitoylated at an adjacent cysteine, substrate of APT1
-
-
r
palmitoyl-CoA + [endothelial nitric oxide synthase]-L-cysteine
[endothelial nitric oxide synthase]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
isozyme DHHC-21
-
-
r
palmitoyl-CoA + [G protein alpha subunit]-L-cysteine
[G protein alpha subunit]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [G-protein alpha subunit Galphai]-L-cysteine
[G-protein alpha subunit Galphai]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
-
-
-
r
palmitoyl-CoA + [Ga protein]-L-cysteine
[Ga protein]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
substrate of DHHC3 and DHHC7
-
-
r
palmitoyl-CoA + [GAP-43 protein]-L-cysteine
[GAP-43 protein]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
substrate of DHHC7 and DHHC15
-
-
r
palmitoyl-CoA + [Gialpha1]-L-cysteine
[Gialpha1]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [H-Ras]-L-cysteine
[H-Ras]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [Lck]-L-cysteine
[Lck]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
nonreceptor tyrosine kinase
-
-
r
palmitoyl-CoA + [protein]-L-cysteine
[protein]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [PSD95]-L-cysteine
[Ras]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
possible substrate of DHHC15 and, to a lesser extent, DHHC2, DHHC3, and DHHC7
-
-
r
palmitoyl-CoA + [Ras1p]-L-cysteine
[Ras1p]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
Ras oncogene homologues, Ras1p and Ras2p, undergo reversible palmitoylation by Erf2p on a Cys residue adjacent to the canonical CaaX box prenylation motif at the C-terminus of the protein
-
-
r
palmitoyl-CoA + [Ras2p]-L-cysteine
[Ras2p]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
Ras oncogene homologues, Ras1p and Ras2p, undergo reversible palmitoylation by Erf2p on a Cys residue adjacent to the canonical CaaX box prenylation motif at the C-terminus of the protein. both Erf2p and Erf4p are involved in the palmitoylation of Ras2p, overview. Mutation of the palmitoylated Cys to Ser abolishes palmitoylation and results in a mislocalization of Ras2p from the plasma membrane to endomembranes. Yeast Erf2p-Erf4p Ras PAT work best with yeast Ras2 protein and less well with mammalian myristoylated GiR subunits or mammalian Ha-Ras. Long chain acyl-CoA substrates, 16 and 18 carbons, are preferred over shorter acyl chains, below 14 carbons
-
-
r
palmitoyl-CoA + [Ras]-L-cysteine
[Ras]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [RGS4]-L-cysteine
[RGS4]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [rhodopsin]-L-cysteine
[rhodopsin]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
PAT incorporates fatty acid into rhodopsin with higher efficiency, 10times higher initial rate, as compared to autoacylation, presence of deacylated, free cysteine residues in dark-adapted rhodopsin increases palmitoylation via PAT
-
-
r
palmitoyl-CoA + [SNAP-25]-L-cysteine
[SNAP-25]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
substrate of DHHC3 and DHHC7
-
-
r
palmitoyl-CoA + [Vac8p]-L-cysteine
[Vac8p]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
palmitoyl-CoA + [Vac8]-L-cysteine
[Vac8]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
Vac8 is a substrate of Pfa3, Vac8 is a myristoylated and palmitoylated protein that localizes to the vacuolar membrane and is required for vacuolar fusion
-
-
r
palmitoyl-CoA + [Yck2p]-L-cysteine
[Yck2p]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
Akr1p is a palmitoyltransferase for Yck2p that catalyzes the transfer of palmitate from palmitoyl-CoA to a C-terminal Cys residue, formation of an Akr1p-palmitoyl intermediate
-
-
r
palmitoyl-CoA + [Yck2]-L-cysteine
[Yck2]-S-palmitoyl-L-cysteine + CoA
show the reaction diagram
-
yeast casein kinase Yck2 is a substrate of Akr1
-
-
r
additional information
?
-