2.3.1.226: carboxymethylproline synthase
This is an abbreviated version!
For detailed information about carboxymethylproline synthase, go to the full flat file.
Word Map on EC 2.3.1.226
-
2.3.1.226
-
crotonase
-
functionalised
-
methylmalonyl-coa
-
carbapenams
-
beta-lactams
-
synthesis
-
carboxylase
-
biocatalysis
-
cyclization
-
synthases
-
bicyclic
-
malonyl-coenzyme
-
acetyl-coa
-
crotonyl-coa
-
simplest
-
stereoselective
-
medicine
- 2.3.1.226
- crotonase
-
functionalised
- methylmalonyl-coa
-
carbapenams
- beta-lactams
- synthesis
- carboxylase
-
biocatalysis
-
cyclization
- synthases
-
bicyclic
-
malonyl-coenzyme
- acetyl-coa
- crotonyl-coa
-
simplest
-
stereoselective
- medicine
Reaction
Synonyms
CarB
ECTree
Advanced search results
Engineering
Engineering on EC 2.3.1.226 - carboxymethylproline synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
H229A
M108A
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 45:55 compared to wild-type ratio of 55:45
M108I
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 92:8 compared to wild-type ratio of 55:45
M108L
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 47:53 compared to wild-type ratio of 55:45. Forms the C6 epimers (6R):(6S) of (2S,5S)-6-ethyl-5-carboxymethylproline in the ratio of 72:18 compared to wild-type ratio of 65:35. Forms the C7 epimers (7R):(7S) of 7-methyl-(2S,6S)-carboxymethylpipecolic acid in the ratio of 60:40 compared to the wild-type ration of 66:34
M108V
Q111N
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 70:30 compared to wild-type ratio of 55:45
W79A
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 16:84 compared to wild-type ratio of 55:45. Forms the C6 epimers (6R):(6S) of (2S,5S)-6-ethyl-5-carboxymethylproline in the ratio of 12:88 compared to wild-type ratio of 65:35. Forms the C7 epimers (7R):(7S) of 7-methyl-(2S,6S)-carboxymethylpipecolic acid in the ratio of 1:99 compared to the wild-type ration of 66:34
W79F
W79F/M108A
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 11:89 compared to wild-type ratio of 55:45. Forms the C6 epimers (6R):(6S) of (2S,5S)-6-ethyl-5-carboxymethylproline in the ratio of 17:83 compared to wild-type ratio of 65:35. Forms the C7 epimers (7R):(7S) of 7-methyl-(2S,6S)-carboxymethylpipecolic acid in the ratio of 5:95 compared to the wild-type ration of 66:34
W79F/M108V
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 56:44 compared to wild-type ratio of 55:45. Forms the C6 epimers (6R):(6S) of (2S,5S)-6-ethyl-5-carboxymethylproline in the ratio of 34:66 compared to wild-type ratio of 65:35. Forms the C7 epimers (7R):(7S) of 7-methyl-(2S,6S)-carboxymethylpipecolic acid in the ratio of 24:76 compared to the wild-type ration of 66:34
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 75:25 compared to wild-type ratio of 55:45
H229A
-
the CarB variant is able to form (2S,7S)-7-(carboxymethyl)-azepane-2-carboxylic acid from malonyl-CoA and L-aminopimelate semialdehyde in a yield of about 3 times higher than that obtained with wild-type CarB
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 95:5 compared to wild-type ratio of 55:45
M108V
mutant is able to convert (2S)-methylmalonyl-CoA/L-glutamate semialdehyde/5-hydroxyproline/pyrroline-5-carboxylate to (6R)-6-methyl-(2S,5S)-5-carboxymethylproline
-
forms the C6 epimers (6R):(6S) of (2S,5S)-6-methyl-5-carboxymethylproline in the ratio of 17:83 compared to wild-type ratio of 55:45. Forms the C6 epimers (6R):(6S) of (2S,5S)-6-ethyl-5-carboxymethylproline in the ratio of 32:68 compared to wild-type ratio of 65:35. Forms the C7 epimers (7R):(7S) of 7-methyl-(2S,6S)-carboxymethylpipecolic acid in the ratio of : compared to the wild-type ration of 17:83
W79F
mutant is able to convert (2S)-ethylmalonyl-CoA/L-glutamate semialdehyde/5-hydroxyproline/pyrroline-5-carboxylate to (6R)-6-ethyl-(2S,5S)-5-carboxymethylproline