2.3.1.230: 2-heptyl-4(1H)-quinolone synthase

This is an abbreviated version!
For detailed information about 2-heptyl-4(1H)-quinolone synthase, go to the full flat file.

2,4-dihydroxyquinoline synthase, PqsBC, PqsD, PsqD

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Results	in table
4	AA Sequence
2	Application
6	Cloned(Commentary)
3	Crystallization (Commentary)
6	General Information
47	IC50 Value
57	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
3	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
15	Organism
4	Pathway
2	pH Optimum
12	Protein Variants
6	Purification (Commentary)
4	Reaction
15	Reference
1	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
3	Subunits
8	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Engineering on EC 2.3.1.230 - 2-heptyl-4(1H)-quinolone synthase

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C112A

C112S

H257F

N287A

inactive, anthraniloyl remains covalently bound to C112, further supporting that N87 does not take part in the cleavage of anthraniloyl-CoA

S317A

activity similar to wild-type

S317F