2.3.1.230: 2-heptyl-4(1H)-quinolone synthase
This is an abbreviated version!
For detailed information about 2-heptyl-4(1H)-quinolone synthase, go to the full flat file.
Word Map on EC 2.3.1.230
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2.3.1.230
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arachidonic
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20-hydroxyeicosatetraenoic
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omega-hydroxylase
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constrictor
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phenylephrine
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microcirculation
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cyp4a2
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clofibrate
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ppars
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lauric
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omega-hydroxylation
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interlobar
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20-hydroxyeicosa-6z,15z-dienoic
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myogenic
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n-methylsulfonyl-12,12-dibromododec-11-enamide
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proliferators
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nafenopin
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arterioles
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vasoconstrictor
- 2.3.1.230
-
arachidonic
-
20-hydroxyeicosatetraenoic
-
omega-hydroxylase
-
constrictor
- phenylephrine
-
microcirculation
- cyp4a2
- clofibrate
-
ppars
-
lauric
-
omega-hydroxylation
-
interlobar
-
20-hydroxyeicosa-6z,15z-dienoic
-
myogenic
- n-methylsulfonyl-12,12-dibromododec-11-enamide
-
proliferators
-
nafenopin
-
arterioles
-
vasoconstrictor
Reaction
Synonyms
2,4-dihydroxyquinoline synthase, PqsBC, PqsD, PsqD
ECTree
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General Information
General Information on EC 2.3.1.230 - 2-heptyl-4(1H)-quinolone synthase
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metabolism
physiological function
Q9I4X2; Q9I4X1
PqsBC, a key enzyme in the biosynthesis of the quorum-sensing signal molecules 2-heptyl-4(1H)-quinolone and Pseudomonas quinolone signal
metabolism
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PqsBC, a key enzyme in the biosynthesis of the quorum-sensing signal molecules 2-heptyl-4(1H)-quinolone and Pseudomonas quinolone signal
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PqsD is a quinolone signal biosynthetic enzyme
physiological function
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synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa and secreted into growth medium in stationary phase. The enzyme is essential for Pseudomonas quinolone signal synthesis
physiological function
4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines
physiological function
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4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines
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