2.3.1.230: 2-heptyl-4(1H)-quinolone synthase
This is an abbreviated version!
For detailed information about 2-heptyl-4(1H)-quinolone synthase, go to the full flat file.
Word Map on EC 2.3.1.230
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2.3.1.230
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arachidonic
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20-hydroxyeicosatetraenoic
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omega-hydroxylase
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constrictor
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phenylephrine
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microcirculation
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cyp4a2
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clofibrate
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ppars
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lauric
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omega-hydroxylation
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interlobar
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20-hydroxyeicosa-6z,15z-dienoic
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myogenic
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n-methylsulfonyl-12,12-dibromododec-11-enamide
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proliferators
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nafenopin
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arterioles
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vasoconstrictor
- 2.3.1.230
-
arachidonic
-
20-hydroxyeicosatetraenoic
-
omega-hydroxylase
-
constrictor
- phenylephrine
-
microcirculation
- cyp4a2
- clofibrate
-
ppars
-
lauric
-
omega-hydroxylation
-
interlobar
-
20-hydroxyeicosa-6z,15z-dienoic
-
myogenic
- n-methylsulfonyl-12,12-dibromododec-11-enamide
-
proliferators
-
nafenopin
-
arterioles
-
vasoconstrictor
Reaction
Synonyms
2,4-dihydroxyquinoline synthase, PqsBC, PqsD, PsqD
ECTree
2.3.1.230 2-heptyl-4(1H)-quinolone synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.230 - 2-heptyl-4(1H)-quinolone synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + 2-aminobenzoyl-CoA
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
2-aminobenzoyl-CoA i.e. anthraniloyl-CoA
i.e. 2,4-dihydroxyquinoline
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?
malonyl-CoA + 2-aminobenzoyl-CoA
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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2-aminobenzoyl-CoA i.e. anthraniloyl-CoA. PqsD is a key enzyme in the biosynthesis of the signal molecules 2-heptyl-4-hydroxyquinoline and 4-hydroxy-2(1H)-quinolone, that are involved in regulation of virulence factor production and biofilm formation
i.e. 2,4-dihydroxyquinoline
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?
malonyl-CoA + 2-aminobenzoyl-CoA
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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2-aminobenzoyl-CoA i.e. anthraniloyl-CoA. The enzyme is involved in the biosynthesis of the Pseudomonas Quinolone Signal
i.e. 2,4-dihydroxyquinoline
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?
malonyl-CoA + 2-aminobenzoyl-CoA
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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the enzyme is involved in the biosynthesis of 2,4-dihydroxyquinoline. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is a highly interactive organism secreting a variety of chemical signals. One intercellular signaling system unique to Pseudomonas and Burkholderia species is the production of hydrophobic quinolines. These quinoline derivatives are 4-hydroxy-2-heptylquinoline, 3,4-dihydroxy-2-heptylquinoline, and 2,4-dihydroxyquinoline
i.e. 2,4-dihydroxyquinoline
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?
malonyl-CoA + 2-aminobenzoyl-CoA
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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the enzyme is involved in the biosynthesis of the signal molecules 2-heptyl-3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone. These compounds are part of the quorum-sensing systems that is based on the production and release of small signaling molecules, called autoinducers, that increase in concentration as a function of cell density and activate corresponding transcriptional regulators after a threshold concentration has been reached
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?
octanoyl-CoA + (2-aminobenzoyl)acetate
2-heptyl-4-quinolone + CoA + CO2 + H2O
Q9I4X2; Q9I4X1
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?
octanoyl-CoA + (2-aminobenzoyl)acetate
2-heptyl-4-quinolone + CoA + CO2 + H2O
Q9I4X2; Q9I4X1
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?
