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2.3.1.233: 1,3,6,8-tetrahydroxynaphthalene synthase

This is an abbreviated version!
For detailed information about 1,3,6,8-tetrahydroxynaphthalene synthase, go to the full flat file.

Word Map on EC 2.3.1.233

Reaction

5 malonyl-CoA =

1,3,6,8-Tetrahydroxynaphthalene
+ 5 CoA + 5 CO2 +
H2O

Synonyms

1,3,6,8-tetrahydroxynaphthalene synthase, PhlD, PKS, PKS III, PKS1, RppA, SCO1206, SoceCHS1, THN synthase, THNS, type III polyketide synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.233 1,3,6,8-tetrahydroxynaphthalene synthase

Substrates Products

Substrates Products on EC 2.3.1.233 - 1,3,6,8-tetrahydroxynaphthalene synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5 malonyl-CoA
1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O
show the reaction diagram
acetoacetyl-CoA
4-hydroxy-6-methyl-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
acetoacetyl-CoA + 2 malonyl-CoA
4-hydroxy-6-methyl-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
acetoacetyl-CoA + methylmalonyl-CoA
3,6-dimethyl-4-hydroxy-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
-
-
-
-
?
Acetyl-CoA
?
show the reaction diagram
acetyl-CoA
? + CoA + CO2 + H2O
show the reaction diagram
-
-
-
-
?
acetyl-CoA + 2 malonyl-CoA
? + CoA + CO2 + H2O
show the reaction diagram
benzoyl-CoA
? + CoA + CO2 + H2O
show the reaction diagram
-
-
-
-
?
benzoyl-CoA + 2 malonyl-CoA
4-hydroxy-6-phenyl-2H-pyran-2-one + CoA + CO2 + H2O
show the reaction diagram
butyryl-CoA
4-hydroxy-6-propyl-2-pyrone + 4-hydroxy-6-(2'-oxopentyl)-2-pyrone + 1,3,6,8-tetrahydroxynaphthalene + CoA + CO2 + H2O
show the reaction diagram
-
21% activity compared to acetoacetyl-CoA
-
-
?
hexanoyl-CoA
4-hydroxy-6-pentyl-2-pyrone + 4-hydroxy-6-(2'-oxoheptyl)-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
hexanoyl-CoA
? + CoA + CO2 + H2O
show the reaction diagram
-
-
-
-
?
hexanoyl-CoA + 2 malonyl-CoA
4-hydroxy-6-pentyl-2H-pyran-2-one + CoA + CO2 + H2O
show the reaction diagram
isobutyryl-CoA
4-hydroxy-6-isopropyl-2-pyrone + 4-hydroxy-6-(3'-methyl-2'-oxopropyl)-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
-
7% activity compared to acetoacetyl-CoA
-
-
?
isovaleryl-CoA
4-hydroxy-6-isobutyl-2-pyrone + 4-hydroxy-6-(4'-methyl-2'-oxopentyl)-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
-
13% activity compared to acetoacetyl-CoA
-
-
?
lauroyl-CoA
1-(2,4,6-trihydroxyphenyl)-dodecan-1-one + 4-hydroxy-6-(2-oxotridecyl)-2H-pyran-2-one + CoA + CO2 + H2O
show the reaction diagram
malonyl-CoA
1,3,6,8-tetrahydroxynaphthalene + CoA + CO2 + H2O
show the reaction diagram
malonyl-CoA
5 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O
show the reaction diagram
-
-
-
-
?
octanoyl-CoA
6-heptyl-4-hydroxy-2-pyrone + 4-hydroxy-6-(2'-oxononyl)-2-pyrone + 4-hydroxy-6-(2',4',6'-trioxotridecyl)-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
-
6% activity compared to acetoacetyl-CoA
-
-
?
octanoyl-CoA + malonyl-CoA
4-hydroxy-6-(2',4',6'-trioxotridecyl)-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
-
-
-
-
?
phenylacetyl-CoA
6-benzyl-4-hydroxy-2-pyrone + 4-hydroxy-6-(2'-oxo-3'-phenylpropyl)-2-pyrone + CoA + CO2 + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-