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2.3.1.234: N6-L-threonylcarbamoyladenine synthase

This is an abbreviated version!
For detailed information about N6-L-threonylcarbamoyladenine synthase, go to the full flat file.

Reaction

L-threonylcarbamoyladenylate
+
adenine37 in tRNA
=
AMP
 +
N6-L-threonylcarbamoyladenine37 in tRNA

Synonyms

EC 2.6.99.4, Kae1, Qri7, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, t6A synthase, tRNA N6-adenosine threonylcarbamoyltransferase, TsaD, YdiE, ygjD

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.234 N6-L-threonylcarbamoyladenine synthase

Crystallization

Crystallization on EC 2.3.1.234 - N6-L-threonylcarbamoyladenine synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the heterodimer YgjD-YeaZ at 2.3 A shows the presence of a molecule of ADP bound at an atypical site situated at the YgjD-YeaZ interface
2.9 A crystal structure of isoform Qri7 reveals a simple homodimer arrangement that is supplanted by the heterodimerization of YgjD with protein YeaZ
in complex with AMP, to 2.94 A resolution. Two molecules per asymmetric unit, forming a dimer. On the dimerization surface of Qri7, the side chains of Trp136 form hydrogen bonds to the carbonyl groups of the main chains of Ala135 and Arg104, and Gln87 forms hydrogen bonds to the side chains of Asp127 and Lys130. Ala88, Ile90, Gly124, Phe128, Gly131 and Val134 of chains A and B form a hydrophobic surface and contribute to hydrophobic interactions