2.3.1.236: 5-methylnaphthoic acid synthase
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For detailed information about 5-methylnaphthoic acid synthase, go to the full flat file.
Reaction
+ 5 malonyl-CoA + 3 NADPH + 3 H+ = + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+
Synonyms
5-methyl-naphthoic acid synthase, AziB, NPA synthase
ECTree
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Cloned
Cloned on EC 2.3.1.236 - 5-methylnaphthoic acid synthase
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heterologous expression of aziB in Streptomyces albus. Addition of aziB1 (encoding a P450 hydroxylase) and aziB2 (encoding an O-methyltransferase) to aziB in Streptomyces albus allows for the production of 3-methoxy-5-methyl-naohthoic acid as the first building block for skeleton assembly of azinomycin B