2.3.1.239: 10-deoxymethynolide synthase
This is an abbreviated version!
For detailed information about 10-deoxymethynolide synthase, go to the full flat file.
Word Map on EC 2.3.1.239
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2.3.1.239
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venezuelae
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macrolactone
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14-membered
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thioesterase
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narbonolide
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macrolide
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synthases
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6-deoxyerythronolide
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cyclization
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triketide
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hexaketide
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erythromycin
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n-acetylcysteamine
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macrocyclization
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te
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ketosynthase
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ketoreductase
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plasmid-based
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synthesis
- 2.3.1.239
- venezuelae
-
macrolactone
-
14-membered
-
thioesterase
- narbonolide
-
macrolide
- synthases
-
6-deoxyerythronolide
-
cyclization
-
triketide
-
hexaketide
- erythromycin
- n-acetylcysteamine
-
macrocyclization
- te
-
ketosynthase
- ketoreductase
-
plasmid-based
- synthesis
Reaction
+ 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
Synonyms
methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV
ECTree
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Cloned
Cloned on EC 2.3.1.239 - 10-deoxymethynolide synthase
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expression in Escherichia coli
expression of functional polyketide synthase modules in Escherichia coli
overexpression of pikromycin modules PikAIII and PIkAIV in Escherichia coli
the picromycin/methymycin PKS genes (pikAI, PikAII, PikAIII, PikAIV and pikAV) are functionally expressed in the heterologous host Streptomyces lividans, resulting in production of both narbonolide and 10-deoxymethynolide
the thioesterase domain of the methymycin/picromycin synthase (PICS) is functionally expressed in Escherichia coli
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