2.3.1.24: sphingosine N-acyltransferase

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For detailed information about sphingosine N-acyltransferase, go to the full flat file.

Reaction

Synonyms

(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA : sphingosine N-acyltransferase, acyltransferase, sphingosine, C16:0-CerS, CER2, Cer3, ceramide synthase, ceramide synthase 4, ceramide synthase 5, ceramide synthase 6, ceramide synthetase, CerS, CerS4, CerS45, CerS5, CerS6, CNAG_02086, CNAG_02087, CNAG_06717, DLag1, Drosophila longevitiy assurance gene-1 homologue, fatty acyl-CoA:sphingosine acyltransferase, LAC1, LAG1, LAG1 longevity assurance homolog 2, LAG1 longevity assurance homolog 5, LAG12, LASS5, Lass6, LOH2, longevity assurance homolog 5, longevity assurance homolog 6, longevity assurance homologue 5, longevity assurance homologue 6, More, schlank, SpAT, sphinganine N-acyl transferase synthase, sphinganine N-acyltransferase, sphingosine acyltransferase, sphingosine N-acyltransferase, sphingosine/sphinganine acyltransferase, TcCerS, TcCERS1, TRAM homolog 4, translocating chain-associating membrane protein homolog 4, trh1-like, trh4

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.24 sphingosine N-acyltransferase

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Results	in table
8	Activating Compound
136	AA Sequence
4	Application
1	CAS Registry Number
23	Cloned(Commentary)
2	Crystallization (Commentary)
583	Disease/ Diagnostics
5	Expression
63	General Information
1	General Stability
1	IC50 Value
36	Inhibitors
3	Ki Value [mM]
27	KM Value [mM]
35	Localization
12	Metals/Ions
4	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
393	Organism
5	Pathway
8	PDB ID
23	pH Optimum
6	pH Range
11	Posttranslational Modification
21	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
57	Reference
2	Renatured (Commentary)
80	Source Tissue
4	Specific Activity [micromol/min/mg]
118	Substrates and Products (Substrate)
6	Subunits
114	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]

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RENATURED/Commentary

ORGANISM

UNIPROT

LITERATURE

recombinant HA-tagged wild-type CerS5 and HA-tagged chimeric mutant CerS5:TM:CerS2 are reconstituted in 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes

Homo sapiens

Q8N5B7

754101

reconstitution of solubilized membrane enzyme in membrane lipid liposomes. The ability of phospholipids to enhance the activity of solubilized ceramide synthase is specific and structure-related. The most potent stimulator is phosphatidylserine in liposomes, suggesting an important role of the net negative charges

Bos taurus

A0A3Q1MJ30

752899