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2.3.1.24: sphingosine N-acyltransferase

This is an abbreviated version!
For detailed information about sphingosine N-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.24

Reaction

an acyl-CoA
+
sphingosine
=
CoA
+
a ceramide

Synonyms

(dihydro)ceramide synthase, acyl-CoA : sphingosine N-acyltramferase, acyl-CoA : sphingosine N-acyltransferase, acyltransferase, sphingosine, C16:0-CerS, CER2, Cer3, ceramide synthase, ceramide synthase 4, ceramide synthase 5, ceramide synthase 6, ceramide synthetase, CerS, CerS4, CerS45, CerS5, CerS6, CNAG_02086, CNAG_02087, CNAG_06717, DLag1, Drosophila longevitiy assurance gene-1 homologue, fatty acyl-CoA:sphingosine acyltransferase, LAC1, LAG1, LAG1 longevity assurance homolog 2, LAG1 longevity assurance homolog 5, LAG12, LASS5, Lass6, LOH2, longevity assurance homolog 5, longevity assurance homolog 6, longevity assurance homologue 5, longevity assurance homologue 6, More, schlank, SpAT, sphinganine N-acyl transferase synthase, sphinganine N-acyltransferase, sphingosine acyltransferase, sphingosine N-acyltransferase, sphingosine/sphinganine acyltransferase, TcCerS, TcCERS1, TRAM homolog 4, translocating chain-associating membrane protein homolog 4, trh1-like, trh4

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.24 sphingosine N-acyltransferase

Substrates Products

Substrates Products on EC 2.3.1.24 - sphingosine N-acyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-dehydrosphinganine + palmitoyl-CoA
N-palmitoyl-3-dehydrosphinganine
show the reaction diagram
-
-
-
-
?
a fatty acyl-CoA + phytosphingosine
CoA + an N-acylphytosphingosine
show the reaction diagram
-
-
-
-
?
acyl-CoA + phytosphingosine
CoA + N-acylphytosphingosine
show the reaction diagram
acyl-CoA + sphingosine
?
show the reaction diagram
LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate PtdCho metabolism in pulmonary epithelia
-
-
?
an acyl-CoA + sphinganine
CoA + an N-acylsphinganine
show the reaction diagram
-
-
-
?
an acyl-CoA + sphingosine
CoA + an N-acylsphingosine
show the reaction diagram
-
-
-
?
behenoyl-CoA + sphingosine
CoA + N-behenoylsphingosine
show the reaction diagram
-
-
-
?
D-erythro-sphinganine + palmitoyl-CoA
N-palmitoyl-D-sphinganine
show the reaction diagram
D-sphingosine + palmitoyl-CoA
N-palmitoyl-D-sphingosine + CoA
show the reaction diagram
-
-
-
?
dihydrosphingosine + myristoyl-CoA
N-myristoyldihydrosphingosine + CoA
show the reaction diagram
-
-
-
?
dihydrosphingosine + palmitoyl-CoA
N-palmitoyldihydrosphingosine + CoA
show the reaction diagram
dihydrosphingosine + stearoyl-CoA
N-stearoyldihydrosphingosine + CoA
show the reaction diagram
-
-
-
?
DL-erythro-sphingosine + arachidonoyl-CoA
N-arachidonoyl-DL-sphingosine + CoA
show the reaction diagram
DL-erythro-sphingosine + palmitoyl-CoA
N-palmitoyl-DL-sphingosine + CoA
show the reaction diagram
DL-erythro-sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
show the reaction diagram
-
both the threo and erythro isomers are active as acceptors, the latter is preferred
-
-
?
DL-erythro-sphingosine + stearoyl-CoA
N-stearoyl-DL-sphingosine + CoA
show the reaction diagram
DL-threo-sphingosine + palmitoyl-CoA
N-palmitoyl-DL-sphingosine + CoA
show the reaction diagram
-
both the threo and erythro isomers are active as acceptors, the latter is slightly preferred
-
-
?
DL-threo-sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
show the reaction diagram
-
both the threo and erythro isomers are active as acceptors, the latter is preferred
-
-
?
docosanoyl-CoA + sphingosine
CoA + N-docosanoylsphingosine
show the reaction diagram
-
-
-
?
eicosanoyl-CoA + sphingosine
CoA + N-eicosanoylsphingosine
show the reaction diagram
-
-
-
?
fatty acyl-CoA + dihydrosphingosine
CoA + an N-acyldihydrosphingosine
show the reaction diagram
-
-
-
-
?
hexacosanoyl-CoA + sphingosine
CoA + N-hexacosanoylsphingosine
show the reaction diagram
-
-
-
?
hexanoyl-CoA + sphingosine
CoA + N-hexanoylsphingosine
show the reaction diagram
-
-
-
?
lauroyl-CoA + sphingosine
CoA + N-lauroylsphingosine
show the reaction diagram
-
-
-
?
oleoyl-CoA + sphingosine
CoA + N-oleoylsphingosine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + dihydrosphingosine
CoA + N-palmitoyldihydrosphingosine
show the reaction diagram
no reverse ceramidase activity is detected in Trypanosoma cruzi microsomal fractions
-
-
?
palmitoyl-CoA + sphinganine
CoA + N-palmitoylsphinganine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + sphingosine
CoA + N-palmitoylsphingosine
show the reaction diagram
palmitoyl-CoA + sphingosine
CoA + palmitoylsphingosine
show the reaction diagram
sphinganine + arachidonoyl-CoA
N-arachidonoyl-DL-dihydrosphingosine + CoA
show the reaction diagram
sphinganine + arachidoyl-CoA
N-arachidoylsphinganine + CoA
show the reaction diagram
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoyl-DL-dihydrosphingosine + CoA
show the reaction diagram
sphinganine + palmitoyl-CoA
N-palmitoyldihydrosphingosine + CoA
show the reaction diagram
-
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoylsphinganine + CoA
show the reaction diagram
sphinganine + stearoyl-CoA
N-stearoyl-DL-dihydrosphingosine + CoA
show the reaction diagram
-
i.e. DL-erythro-2-amino-1,3-octadecanediol
-
-
?
sphinganine + stearoyl-CoA
N-stearoylsphinganine + CoA
show the reaction diagram
sphingosine + 2-hydroxy-palmitoyl-CoA
N-2-hydroxy-palmitoyl-sphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + behenoyl-CoA
N-behenoylsphingosine + CoA
show the reaction diagram
sphingosine + eicosanoyl-CoA
N-eicosanoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + hexanoyl-CoA
N-hexanoylsphingosine + CoA
show the reaction diagram
very low activity
-
-
?
sphingosine + lauroyl-CoA
N-lauroylsphingosine + CoA
show the reaction diagram
sphingosine + myristoyl-CoA
N-myristoylsphingosine + CoA
show the reaction diagram
-
-
-
?
sphingosine + oleoyl-CoA
N-oleoylsphingosine + CoA
show the reaction diagram
sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
show the reaction diagram
sphingosine + stearoyl-CoA
N-stearoylsphingosine + CoA
show the reaction diagram
stearoyl-CoA + phytosphingosine
CoA + N-stearoylphytosphingosine
show the reaction diagram
-
-
-
?
stearoyl-CoA + sphingosine
CoA + N-stearoylsphingosine
show the reaction diagram
tetracosanoyl-CoA + sphingosine
CoA + N-tetracosanoylsphingosine
show the reaction diagram
additional information
?
-