2.3.1.242: Kdo2-lipid IVA palmitoleoyltransferase

This is an abbreviated version!
For detailed information about Kdo2-lipid IVA palmitoleoyltransferase, go to the full flat file.

Reaction

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-((9Z)-hexadec-9-enoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

Synonyms

cold-induced palmitoleoyl transferase, ESA02951, Lipid A biosynthesis palmitoleoyltransferase, LpxP, palmitoleoyl-acyl carrier protein-dependent acyltransferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.242 Kdo2-lipid IVA palmitoleoyltransferase

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Results	in table
1494	AA Sequence
1	Cloned(Commentary)
3	Expression
11	General Information
3	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
1	pH Optimum
1	Reaction
10	Reference
12	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.242 - Kdo2-lipid IVA palmitoleoyltransferase

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a palmitoleoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-((9Z)-hexadec-9-enoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein]

Escherichia coli

P0ACV2

the enzyme is involved in the formation of a cold-adapted lipid A. It transfers palmitoleate from palmitoleoyl-[acyl-carrier protein] to Kdo2-lipid IVA, which is also the acceptor for the lpxL-encoded lauroyl transferase. Palmitoleate is not present in lipid A isolated from Escherichia coli grown at 30°C or higher, but it comprises about 11% of the fatty acyl chains of lipid A in cells grown at 12°C. The appearance of palmitoleate at 12°C is accompanied by a decline in laurate from 18% to 5.5%. The palmitoleoyl transferase is induced more than 30fold upon cold shock. The replacement of laurate with palmitoleate in lipid A may reflect the desirability of maintaining the optimal outer membrane fluidity at 12°C

727828

a palmitoleoyl-[acyl-carrier protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(palmitoleoyl)-lipid IVA + a [acyl-carrier protein]

2 entries