2.3.1.243: acyl-Kdo2-lipid IVA acyltransferase

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For detailed information about acyl-Kdo2-lipid IVA acyltransferase, go to the full flat file.

Reaction

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-dodecanoyloxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

Synonyms

ESA01386, Jhp0255, lauroyl-Kdo2-lipid IVA myristoyltransferase, lipid A biosynthesis myristoyltransferase, LpxJ, LpxL, LpxL2, LpxM, MsbB acyltransferase, myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase, tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.243 acyl-Kdo2-lipid IVA acyltransferase

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Results	in table
2640	AA Sequence
2	Application
5	Cloned(Commentary)
1	Crystallization (Commentary)
8	General Information
1	Inhibitors
4	KM Value [mM]
1	Localization
2	Natural Substrates/ Products (Substrates)
15	Organism
10	Pathway
1	pH Optimum
1	pH Stability
2	Protein Variants
2	Purification (Commentary)
1	Reaction
15	Reference
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Cloned

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Cloned on EC 2.3.1.243 - acyl-Kdo2-lipid IVA acyltransferase

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Escherichia coli

P24205

727820

expression in Escherichia coli

2 entries

heterologous overexpression in Escherichia coli membranes

Acinetobacter baumannii

A0A1Y1P7X1

758226

lipid A in lipopolysaccharide (LPS) of Escherichia coli mutant strains is modified by the introduction of myristoyltransferase gene cloned from Klebsiella pneumoniae. When the lpxL2 gene is introduced into the mutant having lipid A containing only 3-hydroxymyristic acids, it produces lipid A with two additional myristic acids (C14:0). When the same gene is introduced into the mutant with pentaacylated lipid A containing one lauric acid (C12:0), C12:0 is replaced by C14:0

Klebsiella pneumoniae

757615