2.3.1.243: acyl-Kdo2-lipid IVA acyltransferase

This is an abbreviated version!
For detailed information about acyl-Kdo2-lipid IVA acyltransferase, go to the full flat file.

Reaction

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-dodecanoyloxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

Synonyms

ESA01386, Jhp0255, lauroyl-Kdo2-lipid IVA myristoyltransferase, lipid A biosynthesis myristoyltransferase, LpxJ, LpxL, LpxL2, LpxM, MsbB acyltransferase, myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase, tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.243 acyl-Kdo2-lipid IVA acyltransferase

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Results	in table
2640	AA Sequence
2	Application
5	Cloned(Commentary)
1	Crystallization (Commentary)
8	General Information
1	Inhibitors
4	KM Value [mM]
1	Localization
2	Natural Substrates/ Products (Substrates)
15	Organism
10	Pathway
1	pH Optimum
1	pH Stability
2	Protein Variants
2	Purification (Commentary)
1	Reaction
15	Reference
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.3.1.243 - acyl-Kdo2-lipid IVA acyltransferase

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fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] O-acyltransferase

The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached at the 2-O position of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for myristoyl (C14) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates.