2.3.1.244: 2-methylbutanoate polyketide synthase

This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.

Reaction

2 malonyl-CoA +

Synonyms

LDKS, LocF, lovastatin diketide synthase, LovF

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.244 2-methylbutanoate polyketide synthase

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Results	in table
4	AA Sequence
1	Application
1	Cofactor
4	General Information
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
7	Organism
4	Pathway
1	Reaction
7	Reference
2	Substrates and Products (Substrate)
1	Subunits
11	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine

(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O

Aspergillus terreus

Q9Y7D5

the enzyme is involved in the lovastatin biosynthetic pathway

731290

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