2.3.1.244: 2-methylbutanoate polyketide synthase
This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.
Reaction
2 malonyl-CoA + + 2 NADPH + 3 H+ + = + 2 CoA + 2 CO2 + 2 NADP+ + +
Synonyms
LDKS, LocF, lovastatin diketide synthase, LovF
ECTree
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Reference
Reference on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase
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Kennedy, J.; Auclair, K.; Kendrew, S.G.; Park, C.; Vederas, J.C.; Hutchinson, C.R.
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
Science
284
1368-1372
1999
Aspergillus terreus (Q9Y7D5)
Xie, X.; Meehan, M.J.; Xu, W.; Dorrestein, P.C.; Tang, Y.
Acyltransferase mediated polyketide release from a fungal megasynthase
J. Am. Chem. Soc.
131
8388-8389
2009
Aspergillus terreus (Q9Y7D5)
Meehan, M.J.; Xie, X.; Zhao, X.; Xu, W.; Tang, Y.; Dorrestein, P.C.
FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF
Biochemistry
50
287-299
2011
Aspergillus terreus (Q9Y7D5)
Itoh, H.; Matsui, M.; Miyamura, Y.; Takeda, I.; Ishii, J.; Kumagai, T.; Machida, M.; Shibata, T.; Arita, M.
Biosynthesis of novel statins by combining heterologous genes from Xylaria and Aspergillus
ACS Synth. Biol.
7
2783-2789
2018
Aspergillus terreus (Q9Y7D5)
Bhargavi, S.; Praveen, V.; Anil Kumar, M.; Savitha, J.
Comparative study on whole genome sequences of Aspergillus terreus (soil fungus) and Diaporthe ampelina (endophytic fungus) with reference to lovastatin production
Curr. Microbiol.
75
84-91
2018
Aspergillus terreus, no activity in Diaporthe ampelina, Aspergillus terreus KM017963
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