Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.1.244: 2-methylbutanoate polyketide synthase

This is an abbreviated version!
For detailed information about 2-methylbutanoate polyketide synthase, go to the full flat file.

Reaction

2 malonyl-CoA +

[2-methylbutanoate polyketide synthase]
+ 2 NADPH + 3 H+ +
S-adenosyl-L-methionine
=
(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]
+ 2 CoA + 2 CO2 + 2 NADP+ +
S-adenosyl-L-homocysteine
+
H2O

Synonyms

LDKS, LocF, lovastatin diketide synthase, LovF

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.244 2-methylbutanoate polyketide synthase

Reference

Reference on EC 2.3.1.244 - 2-methylbutanoate polyketide synthase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kennedy, J.; Auclair, K.; Kendrew, S.G.; Park, C.; Vederas, J.C.; Hutchinson, C.R.
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
Science
284
1368-1372
1999
Aspergillus terreus (Q9Y7D5)
Manually annotated by BRENDA team
Xie, X.; Meehan, M.J.; Xu, W.; Dorrestein, P.C.; Tang, Y.
Acyltransferase mediated polyketide release from a fungal megasynthase
J. Am. Chem. Soc.
131
8388-8389
2009
Aspergillus terreus (Q9Y7D5)
Manually annotated by BRENDA team
Meehan, M.J.; Xie, X.; Zhao, X.; Xu, W.; Tang, Y.; Dorrestein, P.C.
FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF
Biochemistry
50
287-299
2011
Aspergillus terreus (Q9Y7D5)
Manually annotated by BRENDA team
Itoh, H.; Matsui, M.; Miyamura, Y.; Takeda, I.; Ishii, J.; Kumagai, T.; Machida, M.; Shibata, T.; Arita, M.
Biosynthesis of novel statins by combining heterologous genes from Xylaria and Aspergillus
ACS Synth. Biol.
7
2783-2789
2018
Aspergillus terreus (Q9Y7D5)
Manually annotated by BRENDA team
Bhargavi, S.; Praveen, V.; Anil Kumar, M.; Savitha, J.
Comparative study on whole genome sequences of Aspergillus terreus (soil fungus) and Diaporthe ampelina (endophytic fungus) with reference to lovastatin production
Curr. Microbiol.
75
84-91
2018
Aspergillus terreus, no activity in Diaporthe ampelina, Aspergillus terreus KM017963
Manually annotated by BRENDA team