2.3.1.246: 3,5-dihydroxyphenylacetyl-CoA synthase

This is an abbreviated version!
For detailed information about 3,5-dihydroxyphenylacetyl-CoA synthase, go to the full flat file.

Reaction

4 malonyl-CoA =

Synonyms

dpgA

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.246 3,5-dihydroxyphenylacetyl-CoA synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
11	AA Sequence
3	Cloned(Commentary)
2	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
5	Organism
2	Pathway
4	pH Optimum
5	Protein Variants
3	Purification (Commentary)
1	Reaction
5	Reference
5	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 2.3.1.246 - 3,5-dihydroxyphenylacetyl-CoA synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4 malonyl-CoA

(3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O

3 entries

4 malonyl-CoA

3,5-dihydroxyphenylacetyl-CoA + 3 CoA + 4 CO2 + H2O

2 entries

4 malonyl-CoA

(3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O

Amycolatopsis mediterranei

Q939X3

-

729958

-

-

?

4 malonyl-CoA

(3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O

Amycolatopsis mediterranei

Q939X3

the enzyme is involved in the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin

729958

-

-

?

4 malonyl-CoA

(3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O

Amycolatopsis orientalis

-

diketyl-CoA and triketyl-CoA are confirmed to be the intermediates in the enzyme catalyzed synthesis of (3,5-dihydroxyphenylacetyl)-CoA. Polyketone intermediates alternate between the Cys160 residue and CoA through transthioesterification reactions, in which the chain is elongated by enolate attack on the thioester carbon of the enzyme-bound (poly)ketide intermediate by decarboxylation in malonyl-CoA or polyketide-CoA. Polyketone cyclization likely arises on CoA but not on the enzyme. Experimental data suggest that cyclization of linear tetraketidyl-CoA occurs in concert with or before decarboxylation of the terminal carboxyl group

729594

-

-

?

4 malonyl-CoA

3,5-dihydroxyphenylacetyl-CoA + 3 CoA + 4 CO2 + H2O

Amycolatopsis mediterranei

-

-

729197

-

-

?

4 malonyl-CoA

3,5-dihydroxyphenylacetyl-CoA + 3 CoA + 4 CO2 + H2O

Amycolatopsis mediterranei

-

the enzyme is involved in biosynthesis of 3,5-dihydroxyphenylglycine, a key nonproteinogenic residue in the vancomycin family of antibiotics

729197

-

-

?