2.3.1.247: 3-keto-5-aminohexanoate cleavage enzyme
This is an abbreviated version!
For detailed information about 3-keto-5-aminohexanoate cleavage enzyme, go to the full flat file.
Word Map on EC 2.3.1.247
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2.3.1.247
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acetoacetate
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vacuolar
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acidification
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tracer
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h+-ppase
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phosphorus
- 2.3.1.247
- acetoacetate
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vacuolar
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acidification
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tracer
- h+-ppase
- phosphorus
Reaction
Synonyms
3-keto,5-aminohexanoate cleavage enzyme, FN1868, kce
ECTree
2.3.1.247 3-keto-5-aminohexanoate cleavage enzymeAdvanced search results
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General Information on EC 2.3.1.247 - 3-keto-5-aminohexanoate cleavage enzyme
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
metabolism
additional information
enzyme structure determination and analysis, the active site is situated in each monomer at the C-terminal face of the central beta-barrel with a metal ion coordinated by His46, His48, and Glu230, overview
evolution
gene cluster organization in putative lysine-fermenting bacteria, overview
evolution
the enzyme is a representative of a large family of prokaryotic hypothetical proteins, annotated as the domain of unknown function DUF849, it shows the ubiquitous triose phosphate isomerase (TIM) barrel fold and a Zn2+ cation reminiscent of metal-dependent class II aldolases
evolution
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847
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gene cluster organization in putative lysine-fermenting bacteria, overview
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metabolism
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C-1 and C-2 of 3-oxo-5-aminohexanoate are converted mainly to acetoacetate and acetate, whereas C-3 to C-6 are converted mainly to 3-hydroxybutyrate or its coenzyme A thiolester. 3-Aminobutyryl-CoA is then deaminated to form crotonyl-CoA. The enzymes observed in extracts of Brevibacterium sp. can account for the conversion of 3,5-diaminohexanoate to acetyl-CoA, overview
metabolism
the enzyme is involved in the anaerobic fermentation of lysine
metabolism
the enzyme is involved in the fermentation pathway of lysine
metabolism
the enzyme is involved in the the 3-keto-5-aminohexanoate pathway of lysine degradation, tracer experiments on acetate and butyrate formation from lysine and acetate, overview
metabolism
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847
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the enzyme is involved in the the 3-keto-5-aminohexanoate pathway of lysine degradation, tracer experiments on acetate and butyrate formation from lysine and acetate, overview
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metabolism
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847
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the enzyme is involved in the fermentation pathway of lysine
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metabolism
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C-1 and C-2 of 3-oxo-5-aminohexanoate are converted mainly to acetoacetate and acetate, whereas C-3 to C-6 are converted mainly to 3-hydroxybutyrate or its coenzyme A thiolester. 3-Aminobutyryl-CoA is then deaminated to form crotonyl-CoA. The enzymes observed in extracts of Brevibacterium sp. can account for the conversion of 3,5-diaminohexanoate to acetyl-CoA, overview
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