2.3.1.247: 3-keto-5-aminohexanoate cleavage enzyme
This is an abbreviated version!
For detailed information about 3-keto-5-aminohexanoate cleavage enzyme, go to the full flat file.
Word Map on EC 2.3.1.247
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2.3.1.247
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acetoacetate
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vacuolar
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acidification
-
tracer
-
h+-ppase
-
phosphorus
- 2.3.1.247
- acetoacetate
-
vacuolar
-
acidification
-
tracer
- h+-ppase
- phosphorus
Reaction
Synonyms
3-keto,5-aminohexanoate cleavage enzyme, FN1868, kce
ECTree
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Reaction
Reaction on EC 2.3.1.247 - 3-keto-5-aminohexanoate cleavage enzyme
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(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
the enzyme shows a catalytic reaction mechanism that proceeds through deprotonation of the 3-keto-5-aminohexanoate substrate, nucleophilic addition onto an incoming acetyl-CoA, intramolecular transfer of the CoA moiety, and final retro-Claisen reaction leading to acetoacetate and 3-aminobutyryl-CoA, structure-function analysis, docking study and molecular modeling, detailed overview. Absence of detection of any covalent acyl-enzyme intermediate