2.3.1.247: 3-keto-5-aminohexanoate cleavage enzyme

This is an abbreviated version!
For detailed information about 3-keto-5-aminohexanoate cleavage enzyme, go to the full flat file.

Reaction

Synonyms

3-keto,5-aminohexanoate cleavage enzyme, FN1868, kce

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.247 3-keto-5-aminohexanoate cleavage enzyme

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Results	in table
2	Activating Compound
408	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
11	General Information
5	Inhibitors
8	kcat/KM [mM/s]
9	KM Value [mM]
5	Metals/Ions
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
9	Organism
5	Pathway
3	pH Optimum
1	pH Range
5	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
7	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
15	Substrates and Products (Substrate)
3	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
8	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.3.1.247 - 3-keto-5-aminohexanoate cleavage enzyme

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

9 entries

beta-alanyl-CoA + acetoacetate

?

2 entries

DL-3-aminobutanoyl-CoA + 2-methylacetoacetate

(5S)-5-amino-2-methyl-3-oxohexanoate + acetyl-CoA

2 entries

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Brevibacterium sp.

-

-

6044

-

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Brevibacterium sp.

-

preferred substrate, the substrate is cleaved between C-2 and C-3 to form C-2 and C-4 moieties

6044

DL-3-aminobutyryl-CoA and acetoacetate are used in the reverse reaction assay

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Brevibacterium sp. L5

-

-

6044

-

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Brevibacterium sp. L5

-

preferred substrate, the substrate is cleaved between C-2 and C-3 to form C-2 and C-4 moieties

6044

DL-3-aminobutyryl-CoA and acetoacetate are used in the reverse reaction assay

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Candidatus Cloacimonas acidaminovorans

B0VHH0

-

734167

-

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Fusobacterium nucleatum subsp. nucleatum

Q8RHX2

-

3378, 680885

-

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Fusobacterium nucleatum subsp. nucleatum

Q8RHX2

-

3378

DL-3-aminobutanoyl-CoA and acetoacetate are used in the reverse reaction assay

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847

Q8RHX2

-

3378

DL-3-aminobutanoyl-CoA and acetoacetate are used in the reverse reaction assay

-

r

(5S)-5-amino-3-oxohexanoate + acetyl-CoA

L-3-aminobutanoyl-CoA + acetoacetate

Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847

Q8RHX2

-

680885

-

-

r

beta-alanyl-CoA + acetoacetate

?

Fusobacterium nucleatum subsp. nucleatum

Q8RHX2

-

3378

-

-

r

beta-alanyl-CoA + acetoacetate

?

Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847

Q8RHX2

-

3378

-

-

r

DL-3-aminobutanoyl-CoA + 2-methylacetoacetate

(5S)-5-amino-2-methyl-3-oxohexanoate + acetyl-CoA

Fusobacterium nucleatum subsp. nucleatum

Q8RHX2

-

3378

-

-

r

DL-3-aminobutanoyl-CoA + 2-methylacetoacetate

(5S)-5-amino-2-methyl-3-oxohexanoate + acetyl-CoA

Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847

Q8RHX2

-

3378

-

-

r