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2.3.1.252: mycolipanoate synthase

This is an abbreviated version!
For detailed information about mycolipanoate synthase, go to the full flat file.

Reaction

a long-chain acyl-CoA
+ 3 (S)-methylmalonyl-CoA + 6 NADPH + 6 H+ +
holo-[mycolipanoate synthase]
=
mycolipanoyl-[mycolipanoate synthase]
+ 4 CoA + 3 CO2 + 6 NADP+ + 3 H2O

Synonyms

Msl3, Pks2, pks3, polyketide beta-ketoacyl synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.252 mycolipanoate synthase

Reference

Reference on EC 2.3.1.252 - mycolipanoate synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sirakova, T.D.; Thirumala, A.K.; Dubey, V.S.; Sprecher, H.; Kolattukudy, P.E.
The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis
J. Biol. Chem.
276
16833-16839
2001
Mycobacterium tuberculosis (P9WQE9), Mycobacterium tuberculosis ATCC 25618 (P9WQE9)
Manually annotated by BRENDA team
Goyal, R.; Das, A.K.; Singh, R.; Singh, P.K.; Korpole, S.; Sarkar, D.
Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis
J. Biol. Chem.
286
45197-45208
2011
Mycobacterium tuberculosis (A0A089QRB9), Mycobacterium tuberculosis H37Rv (A0A089QRB9)
Manually annotated by BRENDA team
Dubey, V.S.; Sirakova, T.D.; Kolattukudy, P.E.
Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation
Mol. Microbiol.
45
1451-1459
2002
Mycobacterium tuberculosis (A0A089QRB9), Mycobacterium tuberculosis H37Rv (A0A089QRB9)
Manually annotated by BRENDA team
Walters, S.B.; Dubnau, E.; Kolesnikova, I.; Laval, F.; Daffe, M.; Smith, I.
The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis
Mol. Microbiol.
60
312-330
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team