2.3.1.26: sterol O-acyltransferase
This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.26
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2.3.1.26
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keratinocytes
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lipoprotein
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immortalize
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tnf
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dermal
-
esterification
-
psoriasis
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esterify
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erk
-
mapks
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chemokine
-
collagen
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atopic
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uvb-induced
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nanoparticles
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atherosclerosis
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keratin
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cosmetic
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dermatitis
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caspase-3
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drug development
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radiation-induced
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photoaging
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macrophage-derived
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cox-2
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filaggrin
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7alpha-hydroxylase
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hairless
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sunscreen
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nutrition
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scratch
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pharmacology
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sunburn
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antiatherosclerotic
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phototoxicity
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hypocholesterolemic
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foam
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hmg-coa
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photoprotective
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desmogleins
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dermatology
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keratinocyte-derived
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ad-like
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suprabasal
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medicine
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cholesterol-fed
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hyperproliferation
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transdermal
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mmp-1
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analysis
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imiquimod
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uvb-irradiated
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involucrin
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cyclobutane
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re-epithelialization
- 2.3.1.26
- keratinocytes
- lipoprotein
-
immortalize
- tnf
- dermal
- esterification
- psoriasis
-
esterify
- erk
- mapks
- chemokine
- collagen
-
atopic
-
uvb-induced
- nanoparticles
- atherosclerosis
- keratin
-
cosmetic
- dermatitis
- caspase-3
- drug development
-
radiation-induced
-
photoaging
-
macrophage-derived
- cox-2
- filaggrin
-
7alpha-hydroxylase
- hairless
-
sunscreen
- nutrition
-
scratch
- pharmacology
- sunburn
-
antiatherosclerotic
- phototoxicity
-
hypocholesterolemic
-
foam
- hmg-coa
-
photoprotective
-
desmogleins
-
dermatology
-
keratinocyte-derived
-
ad-like
-
suprabasal
- medicine
-
cholesterol-fed
-
hyperproliferation
-
transdermal
- mmp-1
- analysis
- imiquimod
-
uvb-irradiated
- involucrin
-
cyclobutane
-
re-epithelialization
Reaction
Synonyms
A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2
ECTree
2.3.1.26 sterol O-acyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.26 - sterol O-acyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + cholesterol
CoA + cholesterol ester
-
-
684773, 684780, 684786, 684799, 684800, 684882, 685566, 685611, 685899, 686600, 688060, 688139, 688767, 689426, 736937
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
ACAT-1 plays an important role in the formation of macrophage-derived foam cells in atherosclerotic lesions
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
-
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the enzyme is relevant for cellular cholesterol esterification in vivo, the regulation in human mononuclear phagocytes indicates that the enzyme is also involved in foam cell formation during early atherogenesis
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the high activity of intestinal enzyme renders it possible that the enzyme plays a role in cholesterol absorption
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
role in lipoprotein metabolism and atherogenesis
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the enzyme plays an important role in maintenance of hepatic cholesterol homeostasis
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the enzyme plays an important role in maintenance of hepatic cholesterol homeostasis
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
hepatic ACAT2 plays a critical role in driving the production of atherogenic lipoproteins
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
-
two closely related enzymes identified that catalyse the esterification of cholesterol using acyl-CoA substrates, namely ACAT1 and ACAT2, the orientation of ACAT2 in the endoplasmic reticulum membrane, in addition to its expression only in liver and intestine, suggests that this enzyme may have as a primary function, the secretion of cholesteryl esters into apolipoprotein B-containing lipoproteins
-
-
?
additional information
?
-
-
two closely related enzymes identified that catalyse the esterification of cholesterol using acyl-CoA substrates, namely ACAT1 and ACAT2, the orientation of ACAT2 in the endoplasmic reticulum membrane, in addition to its expression only in liver and intestine, suggests that this enzyme may have as a primary function, the secretion of cholesteryl esters into apolipoprotein B-containing lipoproteins
-
-
?
