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2.3.1.26: sterol O-acyltransferase

This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.26

Reaction

a long-chain acyl-CoA
+
a sterol
=
CoA
 +
a long-chain 3-hydroxysterol ester

Synonyms

A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.26 sterol O-acyltransferase

Specific Activity

Specific Activity on EC 2.3.1.26 - sterol O-acyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000053 - 0.000008
-
-
0.0000178
-
microsomal preparation
0.0000222
-
microsomes
0.0000293
-
ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, high cholesterol synthesis inhibition, high ChSI
0.0000333
-
ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, low cholesterol synthesis inhibition, low ChSI
0.0000377
-
ACAT2 activity, effect on cholesterol synthesis inhibition on hepatic ACAT2 expression, placebo
0.00005
-
whole homogenate of biopsies from distal duodenum-proximal jejunum
0.000053
-
microsomal preparations from ileum, mean value
0.0000582
-
microsomal fraction without 25-hydroycholesterol
0.00006
-
cholesterol added in Tween 80
0.000062
-
microsomal preparations from duodenum, mean value
0.000063
-
cholesterol added in acetone
0.00008
-
solubilized enzyme
0.000081
-
ACAT activity in liver, 100 mg/kg/day esculeoside A
0.000088
-
ACAT activity in peritoneal macrophage, 100 mg/kg/day esculeoside A
0.000089
-
microsomes + 5 mM ATP + 50 mM NaF + 5 mM MgCl2 + 0.005 mM cAMP + 0.005 mg protein kinase
0.000093
-
microsomes + 5 mM ATP
0.0000982
-
microsomal fraction with 25-hydroycholesterol
0.000099
-
microsomes + 5 mM ATP + 50 mM NaF + 5 mM MgCl2
0.0001042
-
aortic microsomal preparation
0.000117
-
control microsomes
0.000126
-
microsomes + 5 mM MgCl2 + 50 mM NaF
0.000132
-
microsomes + 50 mM NaF
0.000144
0.00015
0.000156
-
ACAT activity in liver, control
0.000169
-
microsomes + 5 mM MgCl2
0.00021
-
microsomal preparations from jejunum, mean value
0.000368
-
day 30 of development, endogenous cholesterol as substrate
0.000808
-
microsomal preparation from day 40 of development measured at 33°C
0.000824
-
microsomal preparation from day 40 of development measured at 37°C
0.00087
-
small intestine microsomes
0.0009
-
recombinant enzyme
0.0012
-
recombinant enzyme ACAT1, vector: pcDNA3+, cell type: AC29
0.00135
-
liver microsomes
0.001585
-
day 50 of development, endogenous cholesterol as substrate
0.0017
-
liver microsomes
0.0019
-
recombinant enzyme ACAT2, vector: pCMV5, cell type: AC29
0.0022
-
recombinant enzyme ACAT2, vector: pcDNA3+, cell type: AC29
0.0037
-
adrenal microsomes
0.0038
-
recombinant enzyme ACAT2, vector: pcDNA3+, cell type: COS
0.00561
-
TNFalpha treatment, duration 1 h
0.00562
0.00842
-
TNFalpha treatment, duration 2 h
0.00868
-
TNFalpha treatment, duration 6 h
0.0102
-
TNFalpha treatment, duration 12 h
0.01121
-
TNFalpha treatment, duration 24 h
0.0127
-
ACAT2 activity in HuH-7 cells, control
0.015
-
partially purified enzyme
0.0192
-
ACAT2 activity in HuH-7 cells, 30 microM HDL cholesterol
0.02041
-
TNFalpha treatment, duration 48 h
0.0347
-
ACAT2 activity in HuH-7 cells, 0.5 mM LDL cholesterol
0.039
-
ACAT2 activity in HuH-7 cells, control
0.0558
-
ACAT1 activity in HuH-7 cells, control
0.0701
-
ACAT1 activity in HuH-7 cells, 0.5 mM LDL cholesterol
0.086
-
ACAT1 activity in HuH-7 cells, control
0.0946
-
ACAT2 activity in HuH-7 cells, 0.1 mM free cholesterol
0.1102
-
ACAT1 activity in HuH-7 cells, 0.1 mM free cholesterol
0.1861
-
ACAT1 activity in HuH-7 cells, 30 microM HDL cholesterol
2210
-
ACAT2 activity in Hep-G2 cells, control
3.5 - 4
-
purified recombinant enzyme
3220
-
ACAT2 activity in Hep-G2 cells, control
4650
-
ACAT1 activity in Hep-G2 cells, 1.5 mM LDL cholesterol
4730
-
ACAT1 activity in Hep-G2 cells, 1 mM HDL cholesterol
4980
-
ACAT1 activity in Hep-G2 cells, control
5030
-
ACAT2 activity in Hep-G2 cells, 1.5 mM LDL cholesterol
5750
-
ACAT1 activity in Hep-G2 cells, control
5810
-
ACAT1 activity in Hep-G2 cells, 0.9 mM free cholesterol
6230
-
ACAT2 activity in Hep-G2 cells, 1 mM HDL cholesterol
9560
-
ACAT2 activity in Hep-G2 cells, 0.9 mM free cholesterol
additional information