2.3.1.31: homoserine O-acetyltransferase
This is an abbreviated version!
For detailed information about homoserine O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.31
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2.3.1.31
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l-methionine
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ping-pong
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o-acetylhomoserine
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acetyl-enzyme
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succinyl-coa
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sulfhydrylase
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gamma-hydroxyl
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o-acetyl-l-homoserine
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medicine
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molecular biology
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drug development
- 2.3.1.31
- l-methionine
-
ping-pong
- o-acetylhomoserine
-
acetyl-enzyme
- succinyl-coa
-
sulfhydrylase
-
gamma-hydroxyl
- o-acetyl-l-homoserine
- medicine
- molecular biology
- drug development
Reaction
Synonyms
acetyltransferase, homoserine, CnHTA, DcsE, HAT, homoserine acetyltransferase, homoserine O-acetyltransferase, homoserine transacetylase, homoserine transsuccinylase, homoserine-O-transacetylase, HTA, HTS, L-homoserine O-acetyltransferase, MaHTA, MaMetX, MET2, MetA, MetX, MetXA, metX_1, metX_2, MhHTA, MhMetX, MsHAT, MtHTA, MtMetX, TmHTS
ECTree
2.3.1.31 homoserine O-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.31 - homoserine O-acetyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
beta-hydroxybutyryl-CoA + L-homoserine
CoA + beta-hydroxybutyryl-L-homoserine
-
-
-
-
?
crotonyl-CoA + L-homoserine
CoA + O-crotonyl-L-homoserine
-
low activity
-
-
r
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
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functions as homoserine transacetylase rather than homoserine transsuccinylase despite its more than 50% sequence identity with homoserine transsuccinylase
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
preference for acetyl-CoA
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
first reaction in L-methionine biosynthesis
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
a key enzyme in methionine biosynthesis
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
preference for acetyl-CoA
-
r
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
control point in the pathway
-
r
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
first reaction in L-methionine biosynthesis
-
r
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
first reaction in L-methionine biosynthesis
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
intermediate in methionine biosynthesis
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
acetyl imidazole cannot replace acetyl-CoA
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
acetyl phosphate, acetyl carnitine, acetyl-[acyl-carrier-protein] from E. coli
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
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acetyl phosphate, acetyl carnitine, acetyl-[acyl-carrier-protein] from E. coli
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ir
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
succinyl-CoA cannot replace acetyl-CoA
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ir
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
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not D-homoserine or any other hydroxy-L-amino acid
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ir
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
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the enzyme is a catalyst in the biochemical pathway that metabolizes Asp to Met in fungi
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
homoserine transacetylase catalyzes the acetylation of L-homoserine via a covalent acyl-enzyme intermediate through an active-site Ser
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
-
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
the enzyme utilizes a ping-pong kinetic mechanism in which the acetate group of acetyl-CoA is initially transferred to an enzyme nucleophile before subsequent transfer to homoserine
-
-
r
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
succinyl-CoA cannot replace acetyl-CoA
-
?
acetyl-CoA + L-homoserine
CoA + O-acetyl-L-homoserine
-
first reaction in L-methionine biosynthesis
-
-
?
glutaryl-CoA + L-homoserine
CoA + O-glutaryl-L-homoserine
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very low activity
-
-
r
propionyl-CoA + L-homoserine
CoA + O-propionyl-L-homoserine
-
-
-
-
?
succinyl-CoA + L-homoserine
CoA + O-succinyl-L-homoserine
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activity of mutant E111G
-
-
?
succinyl-CoA + L-homoserine
CoA + O-succinyl-L-homoserine
-
very low activity
-
-
r
additional information
?
-
-
catalyzes reversible L-homoserine/O-acetyl-L-homoserine exchange in the absence of acetyl-CoA
-
-
?
additional information
?
-
-
catalyzes reversible L-homoserine/O-acetyl-L-homoserine exchange in the absence of acetyl-CoA
-
-
?
additional information
?
-
-
catalyzes reversible L-homoserine/O-acetyl-L-homoserine exchange in the absence of acetyl-CoA
-
-
?
additional information
?
-
-
deacylates acetyl-CoA in the absence of L-homoserine
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-
?
additional information
?
-
-
catalyzes reversible L-homoserine/O-acetyl-L-homoserine exchange in the absence of acetyl-CoA
-
-
?
additional information
?
-
the enzyme prefers L-serine as a substrate, cf. EC 2.3.1.30, but is also active with L-homoserine, substrate specificity, overview
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-
?
additional information
?
-
the enzyme prefers L-serine as a substrate, cf. EC 2.3.1.30, but is also active with L-homoserine, substrate specificity, overview
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-
?
