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2.3.1.32: lysine N-acetyltransferase

This is an abbreviated version!
For detailed information about lysine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.32

Reaction

acetyl phosphate
+
L-lysine
=
phosphate
 +
N6-acetyl-L-lysine

Synonyms

acetyltransferase p300, acetyltransferase, lysine, ATase1, ATase2, Cbp, cyclic adenosine monophosphate response element-binding binding protein, Esa1, Gcn5, GCN5-A, GCN5-related N-acetyltransferase, GNAT, H4 lysine acetyltransferase, HAT, histone/protein lysine acetyltransferase, KAT, lysine acetyltransferase, NuA4, p/CAF, p300, p300 acetyltransferase, p300/CBP, PCAF, Rtt109 histone acetyltransferase, SePat

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.32 lysine N-acetyltransferase

Activating Compound

Activating Compound on EC 2.3.1.32 - lysine N-acetyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
histone chaperone
-
Rtt109 associates with chaperone Vps75 (H3K9 and H3K23 acetylation in vivo) or Asf1 (H3K56 acetylation in vivo), stimulation of catalytic activity by chaperones, R55109 stimulates histone deposition by the chaperones, the complex of enzyme + chaperone alters substrate specificity, targets to specific loci, enhances acetyltransferase activity, restricts access of non-target proteins, and coordinates the multiple enzyme activities of the complex
-
membrane transporter
for acetyl-CoA and acetyltransferase from cytosol into lumen of the ER/ER Golgi intermediate compartment
-
methylated histone
-
stimulates interaction of NuA4 complex with histone
NuA4
-
cooperation with the NuA4 complex to enhance its functions but independent contribution to acetylation
-
piccolo NuA4 complex
-
accessory proteins to support the function of Esa1, stimulating the catalytic activity of the enzyme
-
SAGA
-
cooperation with the Gcn5 complex to enhance its functions but independent contribution to acetylation
-
SAGA complex
-
histone ubiquitin protease Ubp8 and histone acetyltransferase Gcn5 form a complex
-
additional information
-
the phosphorylation of the receptor-interacting protein 140 (RIP140) by extracellular-signal-related kinase 2 (Erk2) stimulates p300 acetyltransferase to acetylate the RIP140's lysine 158 and lysine 287 residues
-