2.3.1.32: lysine N-acetyltransferase
This is an abbreviated version!
For detailed information about lysine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.32
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2.3.1.32
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coactivator
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chromatin
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transactivation
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e1a
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creb-binding
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gnat
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adenovirus
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oncoproteins
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deacetylases
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hdacs
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nucleosomal
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creb
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hypoxia-inducible
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deacetylation
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element-binding
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bromodomains
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p300-mediated
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smads
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hyperacetylation
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acetylase
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trichostatin
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h3k27ac
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corepressors
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non-histone
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p300-dependent
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accoa
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p53-dependent
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myod
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p53-mediated
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tax
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htlv-1
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medicine
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brd4
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pharmacology
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tata-binding
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selangor
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h3k4me1
- 2.3.1.32
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coactivator
- chromatin
-
transactivation
- e1a
-
creb-binding
-
gnat
- adenovirus
- oncoproteins
- deacetylases
- hdacs
-
nucleosomal
- creb
-
hypoxia-inducible
-
deacetylation
-
element-binding
-
bromodomains
-
p300-mediated
- smads
-
hyperacetylation
-
acetylase
-
trichostatin
-
h3k27ac
-
corepressors
-
non-histone
-
p300-dependent
- accoa
-
p53-dependent
- myod
-
p53-mediated
- tax
- htlv-1
- medicine
- brd4
- pharmacology
-
tata-binding
-
selangor
-
h3k4me1
Reaction
Synonyms
acetyltransferase p300, acetyltransferase, lysine, ATase1, ATase2, Cbp, cyclic adenosine monophosphate response element-binding binding protein, Esa1, Gcn5, GCN5-A, GCN5-related N-acetyltransferase, GNAT, H4 lysine acetyltransferase, HAT, histone/protein lysine acetyltransferase, KAT, lysine acetyltransferase, NuA4, p/CAF, p300, p300 acetyltransferase, p300/CBP, PCAF, Rtt109 histone acetyltransferase, SePat
ECTree
2.3.1.32 lysine N-acetyltransferaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.3.1.32 - lysine N-acetyltransferase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
curcumin
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25 microM inhibit histidine-tagged recombinant p300 with purified human HeLa core histone as substrate by about 75%
garcinol
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10 microM inhibit histidine-tagged recombinant p300 with purified human HeLa core histone as substrate by about 80%
isogarcinol
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10 microM inhibit histidine-tagged recombinant p300 with purified human HeLa core histone as substrate by about 70%
LTK14
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20 microM inhibit histidine-tagged recombinant p300 with purified human HeLa core histone as substrate by about 70%
anacardic acid
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10 microM inhibit histidine-tagged recombinant p300 with purified human HeLa core histone as substrate by about 95%
Plumbagin
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RTK1, naturally occurring hydroxynaphthoquinone, isolated from Plumbago rosea roots, inhibits histone acetylation, and induces apoptosis at higher concentrations, it inhibits p300/CBP-mediated acetylation of p53 lysine 373 non-competitively, 25 microM inhibit histidine-tagged recombinant p300 with purified human HeLa core histone as substrate by about 60% compared to control; RTK1, naturally occurring hydroxynaphthoquinone, isolated from Plumbago rosea roots, it does not inhibit PCAF acetylation of p53 lysine 320 in vivo in HEK-293 cells (pretreated with acetylation inducer doxorubicin), but 10, 25, and 50 microM inhibit FLAG-tagged recombinant PCAF in vitro (30°C) with purified human HeLa core histone as substrate
Plumbagin
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RTK1, naturally occurring hydroxynaphthoquinone, isolated from Plumbago rosea roots
additional information
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no inhibition by cysteine, glutathione, ascorbic acid, Zn2+, Mn2+, Co2+, Ni2+, Fe3+ or acetate
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additional information
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no inhibition of p300 by 5-methoxy-2-methyl-1,4-naphthoquinone (RTK2, alkyl substitution of hydroxyl group), 5-ethoxy-2-methyl-1,4-naphthoquinone (RTK3, alkyl substitution of hydroxyl group), 5-isopropoxy-2-methyl-1,4-naphthoquinone (RTK4, alkyl substitution of hydroxyl group), and 5-[2-(dimethylamino)-ethoxy]-2-methyl-1,4-naphthoquinone (RTK10, N,N-dimethylamine substitution of hydroxyl group), less than 10% inhibition with 6-methyl-5,8-dioxo-5,8-dihydronaphthalen-1-yl acetate (RTK5, acetyl substitution of hydroxyl group), 6-methyl-5,8-dioxo-5,8-dihydronaphthalen-1-yl methanesulfonate (RTK6, sulfonyl substitution of hydroxyl group), 2-methyl-5-(2-piperidin-1-ylethoxy)-1,4-naphthoquinone (RTK7, piperidine substitution of hydroxyl group), 2-methyl-5-(2-morpholin-4-ylethoxy)-1,4-naphthoquinone (RTK8, morpholine substitution of hydroxyl group), and ethyl [(6-methyl-5,8-dioxo-5,8-dihydronaphthalen-1-yl)-oxy]acetate (RTK9, ester substitution of hydroxyl group)
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