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2.3.1.37: 5-aminolevulinate synthase

This is an abbreviated version!
For detailed information about 5-aminolevulinate synthase, go to the full flat file.

Word Map on EC 2.3.1.37

Reaction

succinyl-CoA
+
glycine
=
5-aminolevulinate
 +
CoA
 +
CO2

Synonyms

5-ALA synthase, 5-ALAS, 5-aminolevulinate synthase, 5-aminolevulinate synthetase, 5-aminolevulinic acid synthase, 5-aminolevulinic acid synthetase, ALA, ALA synthase, ALA synthetase, ALA-S, ALAS, ALAS2, alpha-aminolevulinic acid synthase, aminolevulinate synthase, aminolevulinate synthase 2, aminolevulinate synthetase, aminolevulinic acid synthase, aminolevulinic acid synthase 2, aminolevulinic acid synthetase, aminolevulinic synthetase, delta-ALAS, delta-aminolevulinate synthase, delta-aminolevulinate synthetase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthase 2, delta-aminolevulinic acid synthetase, delta-aminolevulinic synthetase, erythroid 5-aminolevulinate synthase, erythroid-specific 5-aminolevulinate synthase, Hem1, hemA, HemT, mALAS-2, sigma-aminolevulinate synthase, synthase, aminolevulinate, synthetase, aminolevulinate

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.37 5-aminolevulinate synthase

General Stability

General Stability on EC 2.3.1.37 - 5-aminolevulinate synthase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
enzyme is susceptible to proteolytic degradation during isolation, tendency to form aggregates
freezing and thawing: precipitation and loss of activity
-
holoenzyme is more stable than apoenzyme
in the presence of denaturing guanidine hydrochloride concentrations at pH 10.5, the rate of enzyme denaturation is 3times faster than at pH 7.5. Both guanidine hydrochloride- and temperature-induced denaturation reduce the enzyme stability at pH 10.5
partially purified enzyme requires high cation concentration, equivalent to 0.3 M NaCl for maximum stabilization
-
pyridoxal 5'-phosphate stabilizes
short half-life
stable to freezing and thawing
-