2.3.1.37: 5-aminolevulinate synthase

This is an abbreviated version!
For detailed information about 5-aminolevulinate synthase, go to the full flat file.

Reaction

Synonyms

5-ALA synthase, 5-ALAS, 5-aminolevulinate synthase, 5-aminolevulinate synthetase, 5-aminolevulinic acid synthase, 5-aminolevulinic acid synthetase, ALA, ALA synthase, ALA synthetase, ALA-S, ALAS, ALAS2, alpha-aminolevulinic acid synthase, aminolevulinate synthase, aminolevulinate synthase 2, aminolevulinate synthetase, aminolevulinic acid synthase, aminolevulinic acid synthase 2, aminolevulinic acid synthetase, aminolevulinic synthetase, delta-ALAS, delta-aminolevulinate synthase, delta-aminolevulinate synthetase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthase 2, delta-aminolevulinic acid synthetase, delta-aminolevulinic synthetase, erythroid 5-aminolevulinate synthase, erythroid-specific 5-aminolevulinate synthase, Hem1, hemA, HemT, mALAS-2, sigma-aminolevulinate synthase, synthase, aminolevulinate, synthetase, aminolevulinate

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.37 5-aminolevulinate synthase

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Results	in table
34	Activating Compound
9466	AA Sequence
14	Application
1	CAS Registry Number
44	Cloned(Commentary)
117	Cofactor
2	Crystallization (Commentary)
765	Disease/ Diagnostics
17	Expression
23	General Information
14	General Stability
244	Inhibitors
83	kcat/KM [mM/s]
10	Ki Value [mM]
226	KM Value [mM]
53	Localization
17	Metals/Ions
74	Molecular Weight [Da]
80	Natural Substrates/ Products (Substrates)
337	Organism
1	Oxidation Stability
8	Pathway
76	PDB ID
31	pH Optimum
4	pH Range
3	pH Stability
4	Posttranslational Modification
100	Protein Variants
47	Purification (Commentary)
49	Reaction
13	Reaction Type
156	Reference
1	Renatured (Commentary)
109	Source Tissue
45	Specific Activity [micromol/min/mg]
17	Storage Stability
220	Substrates and Products (Substrate)
45	Subunits
104	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
15	Temperature Stability [°C]
90	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 2.3.1.37 - 5-aminolevulinate synthase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0018 - 0.022

2-hydroxybutanoyl-CoA

4 entries

0.0005 - 0.062

butanoyl-CoA

4 entries

0.0007 - 0.0068

glutaryl-CoA

3 entries

0.00002 - 2

glycine

40 entries

0.055 - 0.117

octanoyl-CoA

3 entries

0.0002 - 250

succinyl-CoA

29 entries

0.0018

2-hydroxybutanoyl-CoA

Mus musculus

-

mutant R85L, pH 7.5, 30°C

706627

0.007

2-hydroxybutanoyl-CoA

Mus musculus

-

wild-type, pH 7.5, 30°C

706627

0.0085

2-hydroxybutanoyl-CoA

Mus musculus

-

mutant R85K, pH 7.5, 30°C

706627

0.022

2-hydroxybutanoyl-CoA

Mus musculus

-

mutant R85L/T430V, pH 7.5, 30°C

706627

0.0005

butanoyl-CoA

Mus musculus

-

mutant R85L/T430V, pH 7.5, 30°C

706627

0.0035

butanoyl-CoA

Mus musculus

-

mutant R85L, pH 7.5, 30°C

706627

0.02

butanoyl-CoA

Mus musculus

-

wild-type, pH 7.5, 30°C

706627

0.062

butanoyl-CoA

Mus musculus

-

mutant R85K, pH 7.5, 30°C

706627

0.0007

glutaryl-CoA

Mus musculus

-

mutant R85K, pH 7.5, 30°C

706627

0.0012

glutaryl-CoA

Mus musculus

-

mutant R85L, pH 7.5, 30°C

706627

0.0068

glutaryl-CoA

Mus musculus

-

wild-type, pH 7.5, 30°C

706627

0.00002

glycine

Mus musculus

-

mutant cosubstrate succinyl-CoA, R85L/T430V, pH 7.5, 30°C

706627

0.00017

glycine

Mus musculus

-

mutant R85K, cosubstrate glutaryl-CoA, pH 7.5, 30°C

706627

0.00018

glycine

Mus musculus

-

mutant R85L, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C

706627

0.0002

glycine

Mus musculus

-

mutant R85L, cosubstrate succinyl-CoA, pH 7.5, 30°C

706627

0.0005

glycine

Mus musculus

-

mutant R85L, cosubstrate butanoyl-CoA, pH 7.5, 30°C

706627

0.0005

glycine

Mus musculus

-

mutant R85L, cosubstrate octanoyl-CoA, pH 7.5, 30°C

706627

0.0019

glycine

Mus musculus

-

mutant S254T, 30°C, pH 7.5

704690

0.0023

glycine

Mus musculus

-

mutant R85K, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C

706627

0.0023

glycine

Mus musculus

P08680

mutant N150W, pH 7.5, 18°C

736491

0.0025

glycine

Mus musculus

P08680

mutant N150H, pH 7.5, 18°C

736491

0.0028

glycine

Mus musculus

-

wild-type, cosubstrate 2-hydroxybutanoyl-CoA, pH 7.5, 30°C

706627

0.0043

glycine

Mus musculus

-

wild-type, cosubstrate butanoyl-CoA, pH 7.5, 30°C

706627

0.0048

glycine

Mus musculus

-

wild-type, cosubstrate glutaryl-CoA, pH 7.5, 30°C

706627

0.005

glycine

Mus musculus

-

mutant R85K, cosubstrate succinyl-CoA, pH 7.5, 30°C

706627

0.005

glycine

Mus musculus

P08680

mutant N150F, pH 7.5, 18°C

736491

0.0056

glycine

Mus musculus

-

wild-type, 30°C, pH 7.5

704690

0.0067

glycine

Mus musculus

-

wild-type, cosubstrate succinyl-CoA, pH 7.5, 30°C

706627

0.007

glycine

Mus musculus

P08680

wild-type enzyme, pH 7.5, 18°C

736491

0.0081

glycine

Mus musculus

P08680

mutant N150A, pH 7.5, 18°C

736491

0.0083

glycine

Mus musculus

-

mutant R85K, cosubstrate butanoyl-CoA, pH 7.5, 30°C

706627

0.0087

glycine

Mus musculus

-

mutant R85K, cosubstrate octanoyl-CoA, pH 7.5, 30°C

706627

0.0136

glycine

Mus musculus

P08680

mutant N150G, pH 7.5, 18°C

736491

0.015

glycine

Mus musculus

-

mutant S254A, 30°C, pH 7.5

704690

0.019

glycine

Cereibacter sphaeroides

Q04512

isoform HemT, pH and temperature not specified in the publication

757686

0.02

glycine

Mus musculus

-

mutant cosubstrate octanoyl-CoA, R85L/T430V, pH 7.5, 30°C

706627

0.02

glycine

Mus musculus

-

wild-type, cosubstrate octanoyl-CoA, pH 7.5, 30°C

706627

0.02

glycine

Cereibacter sphaeroides

Q04512

mutant C281P of isoform HemT, pH and temperature not specified in the publication

757686

0.026

glycine

Cereibacter sphaeroides

Q04512

isoform HemA, pH and temperature not specified in the publication

757686

0.0291

glycine

Mus musculus

P08680

mutant enzyme DELTAmALAS2, at pH 7.5 and 37°C

756100

0.0312

glycine

Mus musculus

P08680

wild type enzyme, at pH 7.5 and 37°C

756100

0.033

glycine

Cereibacter sphaeroides

Q04512

isoform HemA, pH and temperature not specified in the publication

757686

0.049

glycine

Cereibacter sphaeroides

Q04512

isoform HemA, pH and temperature not specified in the publication

757686

0.13

glycine

Mus musculus

-

mutant R85L, cosubstrate glutaryl-CoA, pH 7.5, 30°C

706627

0.79

glycine

Cereibacter sphaeroides

-

mutant enzyme T83S/T363S, at pH 7.2 and 37°C

758299

0.87

glycine

Cereibacter sphaeroides

-

mutant enzyme T83S, at pH 7.2 and 37°C

758299

0.88

glycine

Rhodopseudomonas palustris

-

mutant enzyme H15K, at pH 7.5 and 37°C

756270

1.07

glycine

Cereibacter sphaeroides

-

mutant enzyme T363S, at pH 7.2 and 37°C

758299

1.18

glycine

Rhodopseudomonas palustris

-

wild type enzyme, at pH 7.5 and 37°C

756270

1.22

glycine

Rhodopseudomonas palustris

-

mutant enzyme H29R, at pH 7.5 and 37°C

756270

2

glycine

Cereibacter sphaeroides

-

wild type enzyme, at pH 7.2 and 37°C

758299

0.055

octanoyl-CoA

Mus musculus

-

mutant R85L, pH 7.5, 30°C

706627

0.113

octanoyl-CoA

Mus musculus

-

wild-type, pH 7.5, 30°C

706627

0.117

octanoyl-CoA

Mus musculus

-

mutant R85K, pH 7.5, 30°C

706627

0.0002

succinyl-CoA

Mus musculus

-

mutant R85L/T430V, pH 7.5, 30°C

706627

0.0008

succinyl-CoA

Mus musculus

-

mutant R85L, pH 7.5, 30°C

706627

0.0084

succinyl-CoA

Mus musculus

-

mutant S254A, 30°C, pH 7.5

704690

0.0089

succinyl-CoA

Mus musculus

-

mutant R85K, pH 7.5, 30°C

706627

0.042

succinyl-CoA

Mus musculus

-

mutant S254T, 30°C, pH 7.5

704690

0.073

succinyl-CoA

Cereibacter sphaeroides

-

mutant enzyme T363S, at pH 7.2 and 37°C

758299

0.102

succinyl-CoA

Cereibacter sphaeroides

-

mutant enzyme T83S/T363S, at pH 7.2 and 37°C

758299

0.11

succinyl-CoA

Mus musculus

-

wild-type, 30°C, pH 7.5

704690

0.16

succinyl-CoA

Cereibacter sphaeroides

-

mutant enzyme T83S, at pH 7.2 and 37°C

758299

0.55

succinyl-CoA

Mus musculus

-

wild-type, pH 7.5, 30°C

706627

4.34

succinyl-CoA

Cereibacter sphaeroides

-

wild type enzyme, at pH 7.2 and 37°C

758299

7

succinyl-CoA

Mus musculus

P08680

pH 7.5, 37°C, mutant K221V

736116

27

succinyl-CoA

Mus musculus

P08680

mutant N150F, pH 7.5, 18°C

736491

33

succinyl-CoA

Mus musculus

P08680

mutant N150H, pH 7.5, 18°C

736491

34

succinyl-CoA

Mus musculus

P08680

mutant N150A, pH 7.5, 18°C

736491

35.4

succinyl-CoA

Cereibacter sphaeroides

Q04512

mutant C281P of isoform HemT, pH and temperature not specified in the publication

757686

62.5

succinyl-CoA

Cereibacter sphaeroides

Q04512

isoform HemA, pH and temperature not specified in the publication

757686

67.2

succinyl-CoA

Cereibacter sphaeroides

Q04512

isoform HemT, pH and temperature not specified in the publication

757686

70

succinyl-CoA

Mus musculus

P08680

wild-type enzyme, pH 7.5, 18°C

736491

70.3

succinyl-CoA

Cereibacter sphaeroides

Q04512

isoform HemA, pH and temperature not specified in the publication

757686

71

succinyl-CoA

Mus musculus

P08680

mutant N150G, pH 7.5, 18°C

736491

72.4

succinyl-CoA

Cereibacter sphaeroides

Q04512

isoform HemA, pH and temperature not specified in the publication

757686

82

succinyl-CoA

Mus musculus

P08680

mutant N150W, pH 7.5, 18°C

736491

130

succinyl-CoA

Rhodopseudomonas palustris

-

wild type enzyme, at pH 7.5 and 37°C

756270

140

succinyl-CoA

Rhodopseudomonas palustris

-

mutant enzyme H29R, at pH 7.5 and 37°C

756270

230

succinyl-CoA

Rhodopseudomonas palustris

-

mutant enzyme H15K, at pH 7.5 and 37°C

756270

246

succinyl-CoA

Mus musculus

P08680

mutant enzyme DELTAmALAS2, at pH 7.5 and 37°C

756100

250

succinyl-CoA

Mus musculus

P08680

wild type enzyme, at pH 7.5 and 37°C

756100

250

succinyl-CoA

Mus musculus

P08680

pH 7.5, 37°C, wild-type enzyme

736116