2.3.1.39: [acyl-carrier-protein] S-malonyltransferase

This is an abbreviated version!
For detailed information about [acyl-carrier-protein] S-malonyltransferase, go to the full flat file.

Reaction

Synonyms

EtMCAT, FabD, FabD2, FAS, fatty acid synthase, HpMCAT, malonyl CoA-ACP malonyltransferase, malonyl CoA-ACP transacylase, malonyl CoA-acyl carrier protein transacylase, malonyl coenzyme A-acyl carrier protein transacylase, malonyl coenzyme A:acyl carrier protein transacylase, malonyl transacylase, malonyl transferase, malonyl-CoA acyl carrier protein transacylase, malonyl-CoA-acyl carrier protein transacylase, malonyl-CoA/ACP transacylase, malonyl-CoA/holo-ACP transacylase, malonyl-CoA: ACP transacylase, malonyl-CoA:ACP transacylase, malonyl-CoA:AcpM transacylase, malonyl-CoA:acyl carrier protein transacylase, malonyl-CoA:acyl-carrier protein transacylase, malonyl-CoA�acyl carrier protein transacylase, malonyl-coenzyme A (CoA)/holo-ACP transacylase, malonyl-coenzyme A-holo-acyl-carrier protein transacylase, malonyl-coenzyme A: acyl-carrier protein transacylase, malonyl-coenzyme A:ACP transacylase, malonyl-coenzymeA:acyl-carrier protein transacylase, malonyltransferase, [acyl-carrier-protein], MAT, MCAMT, MCAT, MCT, MdcH, More, mtFabD, SaMCAT, SpnMCAT, XoMCAT, [acyl carrier protein]malonyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.39 [acyl-carrier-protein] S-malonyltransferase

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Results	in table
3	Activating Compound
39861	AA Sequence
5	Application
1	CAS Registry Number
37	Cloned(Commentary)
13	Crystallization (Commentary)
4263	Disease/ Diagnostics
4	Expression
20	General Information
8	General Stability
1	IC50 Value
59	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
78	KM Value [mM]
13	Localization
34	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
111	Organism
11	Pathway
94	PDB ID
26	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
1	Posttranslational Modification
52	Protein Variants
31	Purification (Commentary)
15	Reaction
1	Reaction Type
85	Reference
2	Renatured (Commentary)
20	Source Tissue
46	Specific Activity [micromol/min/mg]
6	Storage Stability
122	Substrates and Products (Substrate)
13	Subunits
102	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
11	Temperature Stability [°C]
35	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.39 - [acyl-carrier-protein] S-malonyltransferase

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SYSTEMATIC NAME

IUBMB Comments

malonyl-CoA:[acyl-carrier protein] S-malonyltransferase

This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis [7]. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate [5]. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88, biotin-independent malonate decarboxylase and EC 7.2.4.4, biotin-dependent malonate decarboxylase. Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase [12]. In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot [10] whereas the enzyme from Pseudomonas putida can use both as substrates [11]. The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate prosthetic group; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA prosthetic group.