2.3.1.4: glucosamine-phosphate N-acetyltransferase

This is an abbreviated version!
For detailed information about glucosamine-phosphate N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyltransferase, glucosamine phosphate, AfGNA1, aminodeoxyglucosephosphate acetyltransferase, AtGNA1, CaGNA1, CDS L316, cgd4_4000, D-glucosamine-6-P N-acetyltransferase, GlcNAc-6-phosphate N-acetyltransferase, GlmU, glucosamine 6-phosphate acetylase, glucosamine 6-phosphate N-acetyltransferase, glucosamine phosphate acetyltransferase, glucosamine-6-phosphate acetylase, glucosamine-6-phosphate acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase 1, GNA, GNA1, HsGNA1, N-acetylglucosamine-6-phosphate synthase, OsGNA1, PF3D7_0629000, phosphoglucosamine acetylase, phosphoglucosamine N-acetylase, phosphoglucosamine transacetylase, ScGNA1, TGGT1_243600

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.4 glucosamine-phosphate N-acetyltransferase

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Results	in table
2	Activating Compound
5497	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
3	Cofactor
7	Crystallization (Commentary)
37	Disease/ Diagnostics
2	Expression
5	General Information
2	General Stability
1	IC50 Value
23	Inhibitors
4	kcat/KM [mM/s]
3	Ki Value [mM]
46	KM Value [mM]
4	Localization
6	Metals/Ions
9	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
52	Organism
4	Pathway
31	PDB ID
15	pH Optimum
1	pH Range
1	pH Stability
27	Protein Variants
13	Purification (Commentary)
2	Reaction
1	Reaction Type
51	Reference
18	Source Tissue
9	Specific Activity [micromol/min/mg]
5	Storage Stability
48	Substrates and Products (Substrate)
9	Subunits
52	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
13	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.3.1.4 - glucosamine-phosphate N-acetyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-acetamido-2,6-dideoxy-6-sulfo-D-glucose

2 entries

2-amino-2,3-dideoxy-3-fluoro-alpha-D-glucopyranosyl phosphate

Mycobacterium tuberculosis

-

inhibition of acetyltransferase activity. Compound cannot substitute the natural substrate GlcN-1-P. Uncompetitive inhibition, compound interacts with the enzyme–substrate complex.

719224

acetyl-CoA

2 entries

CoA

Rattus norvegicus

-

-

486905

D-glucosamine-6-phosphate

Sus scrofa

-

feedback inhibition

486907

EDTA

2 entries

glucose-6-phosphate

Aspergillus fumigatus

-

weak competitive inhibitor

686750

Mn2+

Vigna radiata var. radiata

-

-

486906

Ni2+

Ovis aries

-

-

486901

p-chloromercuribenzoate

4 entries

p-hydroxymercuribenzoate

2 entries

Zn2+

Vigna radiata var. radiata

-

-

486906

additional information

4 entries

-

2-acetamido-2,6-dideoxy-6-sulfo-D-glucose

Bacillus subtilis

-

analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 2.88 mg/ml

719225

2-acetamido-2,6-dideoxy-6-sulfo-D-glucose

Escherichia coli

-

analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 4 mg/ml

719225

acetyl-CoA

Ovis aries

-

high concentrations

486901

acetyl-CoA

Rattus norvegicus

-

complex inhibition pattern

486905

EDTA

Neurospora crassa

-

-

486901

EDTA

Vigna radiata var. radiata

-

20 mM, 50% inhibition

486906

p-chloromercuribenzoate

Neurospora crassa

-

-

486901

p-chloromercuribenzoate

Neurospora crassa

-

1 mM, complete inhibition

486902

p-chloromercuribenzoate

Neurospora crassa

-

-

486903

p-chloromercuribenzoate

Ovis aries

-

0.001 mM, 50% inhibition, 0.01 mM, complete inhibition, reversed by cysteine

486901

p-hydroxymercuribenzoate

Homo sapiens

-

2.5 mM, 81% inhibition of isoenzyme 1, 92% inhibition of isoenzyme 2 and 92.5% inhibition of isoenzyme 3, inhibition by 1.25 mM is reversible upon addition of 2.5 mM dithiothreitol

486908

p-hydroxymercuribenzoate

Vigna radiata var. radiata

-

0.05 mM, 91% inhibition, 0.1 mM, complete inhibition 1 mM L-cysteine restores activity

486906

additional information

Blastocladiella emersonii

-

not inhibited by EDTA

486904

-

additional information

Homo sapiens

Q96EK6

not inhibitory: 1,22-bis(3-methyl-1H-imidazolium-1-yl)docosane dimesylate, N-butanoylglucosaminex02beta-S-2-naphthyl

755991

-

additional information

Neurospora crassa

-

not inhibited by EDTA; not inhibited by iodoacetate

486902

-

additional information

Toxoplasma gondii

S7UFV0

not inhibitory: spermine nor spermidine

758433

-