2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I

This is an abbreviated version!
For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase I, go to the full flat file.

Reaction

Synonyms

3-ketoacyl-ACP synthase, 3-ketoacyl-acyl carrier protein synthase, 3-ketoacyl-acyl-carrier protein synthase I, 3-oxoacyl synthase, 3-oxoacyl-[acyl-carrier-protein] synthase, acyl-malonyl(acyl-carrier-protein)-condensing enzyme, B-ketoacyl-ACP synthase I, beta-ketoacyl ACP synthase I, beta-ketoacyl acyl carrier protein synthase, beta-ketoacyl acyl carrier protein synthase I, beta-ketoacyl synthase, beta-ketoacyl synthetase, beta-ketoacyl [ACP] synthase, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase I, beta-ketoacyl-ACP synthetase, beta-ketoacyl-ACP-synthase, beta-ketoacyl-ACP-synthase I, beta-ketoacyl-acyl carrier protein synthase I, beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-acyl-ACP synthase I, beta-ketoacyl-CoA synthase-I, beta-ketoacyl-[acyl carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacyl-[acyl carrier protein] synthase I, beta-ketoacyl-[acyl-carrier-protein] synthase I, beta-ketoacylsynthase, condensing enzyme, Cys-His-His-type beta-ketoacyl-acyl carrier protein synthase, DpsC, elongase, elongating beta-ketoacyl-acyl carrier protein synthase, FabB, FabBF, FabH, fatty acid condensing enzyme, KAS, Kas A, KAS I, KasA, KasI, KASI-1, KASI-2, KCSI, More, OsKASI, synthase, 3-oxoacyl-[acyl-carrier-protein]

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I

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Results	in table
15	Activating Compound
16618	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
14	Crystallization (Commentary)
36	Disease/ Diagnostics
11	General Information
11	General Stability
3	IC50 Value
96	Inhibitors
17	kcat/KM [mM/s]
3	Ki Value [mM]
65	KM Value [mM]
15	Localization
1	Metals/Ions
49	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
281	Organism
1	Oxidation Stability
26	Pathway
328	PDB ID
21	pH Optimum
9	pH Range
2	Posttranslational Modification
47	Protein Variants
42	Purification (Commentary)
23	Reaction
23	Reaction Type
80	Reference
56	Source Tissue
41	Specific Activity [micromol/min/mg]
9	Storage Stability
242	Substrates and Products (Substrate)
31	Subunits
93	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
2	Temperature Stability [°C]
36	Turnover Number [1/s]

Synonyms

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Synonyms on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3-ketoacyl-ACP synthase

3 entries

3-ketoacyl-acyl carrier protein synthase

-

-

-

-

3-ketoacyl-acyl-carrier protein synthase I

Nicotiana tabacum

A0A3G1E3Q4, A0A3G1E3S8

-

756986

3-oxoacyl synthase

Rattus norvegicus

-

-

661000

3-oxoacyl-[acyl-carrier-protein] synthase

2 entries

acyl-malonyl(acyl-carrier-protein)-condensing enzyme

-

-

-

-

B-ketoacyl-ACP synthase I

Staphylococcus aureus

-

-

756122

beta-ketoacyl ACP synthase I

5 entries

beta-ketoacyl acyl carrier protein synthase

-

-

-

-

beta-ketoacyl acyl carrier protein synthase I

Escherichia coli

E2QPI4

-

719202, 736660

beta-ketoacyl synthase

Rattus norvegicus

-

-

661000

beta-ketoacyl synthetase

-

-

-

-

beta-ketoacyl [ACP] synthase

Homo sapiens

Q9NWU1

-

677030

beta-ketoacyl-ACP synthase

2 entries

beta-ketoacyl-ACP synthase I

4 entries

beta-ketoacyl-ACP synthetase

-

-

-

-

beta-ketoacyl-ACP-synthase

Arabidopsis thaliana

Q8L3X9

-

658746

beta-ketoacyl-ACP-synthase I

Escherichia coli

P0A953

-

757740

beta-ketoacyl-acyl carrier protein synthase I

3 entries

beta-ketoacyl-acyl carrier protein synthetase

-

-

-

-

beta-ketoacyl-acyl-ACP synthase I

Cocos nucifera

V9N3I8

-

758028

beta-ketoacyl-CoA synthase-I

Helianthus annuus

-

-

674095

beta-ketoacyl-[acyl carrier protein (ACP)] synthase III

Staphylococcus aureus

-

-

676903

beta-ketoacyl-[acyl carrier protein] synthase

-

-

-

-

beta-ketoacyl-[acyl carrier protein] synthase I

Oryza sativa

-

-

737055

beta-ketoacyl-[acyl-carrier-protein] synthase I

2 entries

beta-ketoacylsynthase

-

-

-

-

condensing enzyme

-

-

-

-

Cys-His-His-type beta-ketoacyl-acyl carrier protein synthase

Escherichia coli

-

-

673576

DpsC

Streptomyces peucetius

-

-

486934

elongase

Trypanosoma brucei

Q586W9

-

674882

elongating beta-ketoacyl-acyl carrier protein synthase

Plasmodium falciparum

-

-

674777

FabB

5 entries

FabBF

Plasmodium falciparum

-

-

674777

FabH

Staphylococcus aureus

-

-

676903

fatty acid condensing enzyme

-

-

-

-

KAS

6 entries

Kas A

2 entries

KAS I

5 entries

KasA

Mycobacterium tuberculosis

-

-

718888

KasI

Cocos nucifera

V9N3I8

-

737010, 758028

KASI-1

2 entries

KASI-2

2 entries

KCSI

Helianthus annuus

-

-

674095

OsKASI

Oryza sativa

-

-

737055

synthase, 3-oxoacyl-[acyl-carrier-protein]

-

-

-

-

additional information

7 entries

3-ketoacyl-ACP synthase

Escherichia coli

-

-

704553

3-ketoacyl-ACP synthase

Nicotiana tabacum

A0A3G1E3Q4, A0A3G1E3S8

-

756986

3-ketoacyl-ACP synthase

Spinacia oleracea

-

-

486931

3-oxoacyl-[acyl-carrier-protein] synthase

-

-

-

-

3-oxoacyl-[acyl-carrier-protein] synthase

Oryza sativa

-

-

737055

beta-ketoacyl ACP synthase I

Brucella melitensis

Q2YQQ9

-

758309

beta-ketoacyl ACP synthase I

Brucella melitensis 2308

Q2YQQ9

-

-

beta-ketoacyl ACP synthase I

Escherichia coli

P0A953

-

659726

beta-ketoacyl ACP synthase I

Mycobacterium tuberculosis

P9WQD9

-

753732

beta-ketoacyl ACP synthase I

Mycobacterium tuberculosis H37Rv

P9WQD9

-

-

beta-ketoacyl-ACP synthase

Homo sapiens

Q9NWU1

-

677030

beta-ketoacyl-ACP synthase

Trypanosoma brucei

Q586W9

-

674882

beta-ketoacyl-ACP synthase I

Cocos nucifera

V9N3I8

-

737010

beta-ketoacyl-ACP synthase I

Escherichia coli

-

-

673576, 718888

beta-ketoacyl-ACP synthase I

Mycobacterium tuberculosis

-

-

718888

beta-ketoacyl-ACP synthase I

Xanthomonas oryzae pv. oryzae

-

-

718505

beta-ketoacyl-acyl carrier protein synthase I

Jatropha curcas

-

-

757495

beta-ketoacyl-acyl carrier protein synthase I

Nicotiana tabacum

A0A3G1E3Q4, A0A3G1E3S8

-

756986

beta-ketoacyl-acyl carrier protein synthase I

Xanthomonas oryzae pv. oryzae

-

-

718505

beta-ketoacyl-[acyl-carrier-protein] synthase I

Arabidopsis thaliana

P52410

-

720679

beta-ketoacyl-[acyl-carrier-protein] synthase I

Escherichia coli

-

-

719202

FabB

Brucella melitensis

Q2YQQ9

-

758309

FabB

Brucella melitensis 2308

Q2YQQ9

-

-

FabB

Escherichia coli

-

-

704553, 718888

FabB

Escherichia coli

P0A953

-

757740

FabB

Staphylococcus aureus

-

-

756122

KAS

Allium ampeloprasum

-

-

486935

KAS

Brassica napus

-

-

486932

KAS

Homo sapiens

Q9NWU1

-

677030

KAS

Spinacia oleracea

-

-

486931

KAS

Streptomyces glaucescens

-

-

486933, 486938

KAS

Synechocystis sp.

-

-

486936, 486940

Kas A

Mycobacterium tuberculosis

P9WQD9

-

753732

Kas A

Mycobacterium tuberculosis H37Rv

P9WQD9

-

-

KAS I

Brucella melitensis

Q2YQQ9

-

758309

KAS I

Brucella melitensis 2308

Q2YQQ9

-

-

KAS I

Escherichia coli

-

-

673576

KAS I

Escherichia coli

E2QPI4

-

719202, 736660

KAS I

Escherichia coli

P0A953

-

659726

KASI-1

Jatropha curcas

-

isoform

757495

KASI-1

Nicotiana tabacum

A0A3G1E3Q4

isoform

756986

KASI-2

Jatropha curcas

-

isoform

757495

KASI-2

Nicotiana tabacum

A0A3G1E3S8

isoform

756986

additional information

Clostridium kluyveri

-

in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86

486863

additional information

Escherichia coli

-

in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86

486863

additional information

Escherichia coli

-

in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86

486864

additional information

Escherichia coli

P0A953

the enzyme belongs to the superfamily of condensing enzymes which includes thiolases

659726

additional information

Streptomyces glaucescens

-

enzyme shows also acetyl coenzyme A-acyl-carrier-protein transacylase activity EC 2.3.1.38, 12% compared to beta-keto-[acyl-carrier-protein] synthase activity EC 2.3.1.41

486933

additional information

Streptomyces peucetius

-

gene DpsC, encoding apolyketide synthase, exhibits also beta-keto-[acyl-carrier-protein] synthase III activity, which is restricted for propionyl-[acyl-carrier-protein] as the only [acyl-carrier-protein]-substrate

486934

additional information

Synechocystis sp.

-

3 structural classes of condensing enzymes

486940