2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I

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For detailed information about beta-ketoacyl-[acyl-carrier-protein] synthase I, go to the full flat file.

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Synonyms

3-ketoacyl-ACP synthase, 3-ketoacyl-acyl carrier protein synthase, 3-ketoacyl-acyl-carrier protein synthase I, 3-oxoacyl synthase, 3-oxoacyl-[acyl-carrier-protein] synthase, acyl-malonyl(acyl-carrier-protein)-condensing enzyme, B-ketoacyl-ACP synthase I, beta-ketoacyl ACP synthase I, beta-ketoacyl acyl carrier protein synthase, beta-ketoacyl acyl carrier protein synthase I, beta-ketoacyl synthase, beta-ketoacyl synthetase, beta-ketoacyl [ACP] synthase, beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP synthase I, beta-ketoacyl-ACP synthetase, beta-ketoacyl-ACP-synthase, beta-ketoacyl-ACP-synthase I, beta-ketoacyl-acyl carrier protein synthase I, beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-acyl-ACP synthase I, beta-ketoacyl-CoA synthase-I, beta-ketoacyl-[acyl carrier protein (ACP)] synthase III, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacyl-[acyl carrier protein] synthase I, beta-ketoacyl-[acyl-carrier-protein] synthase I, beta-ketoacylsynthase, condensing enzyme, Cys-His-His-type beta-ketoacyl-acyl carrier protein synthase, DpsC, elongase, elongating beta-ketoacyl-acyl carrier protein synthase, FabB, FabBF, FabH, fatty acid condensing enzyme, KAS, Kas A, KAS I, KasA, KasI, KASI-1, KASI-2, KCSI, More, OsKASI, synthase, 3-oxoacyl-[acyl-carrier-protein]

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I

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Results	in table
15	Activating Compound
16618	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
14	Crystallization (Commentary)
36	Disease/ Diagnostics
11	General Information
11	General Stability
3	IC50 Value
96	Inhibitors
17	kcat/KM [mM/s]
3	Ki Value [mM]
65	KM Value [mM]
15	Localization
1	Metals/Ions
49	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
281	Organism
1	Oxidation Stability
26	Pathway
328	PDB ID
21	pH Optimum
9	pH Range
2	Posttranslational Modification
47	Protein Variants
42	Purification (Commentary)
23	Reaction
23	Reaction Type
80	Reference
56	Source Tissue
41	Specific Activity [micromol/min/mg]
9	Storage Stability
242	Substrates and Products (Substrate)
31	Subunits
93	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
2	Temperature Stability [°C]
36	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I

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SYSTEMATIC NAME

IUBMB Comments

acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)

This enzyme is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. The enzyme can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16) [4]. The substrate specificity is very similar to that of EC 2.3.1.179, beta-ketoacyl-ACP synthase II, with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Delta9) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature [4,5].