2.3.1.43: phosphatidylcholine-sterol O-acyltransferase
This is an abbreviated version!
For detailed information about phosphatidylcholine-sterol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.43
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2.3.1.43
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lipoprotein
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hdl
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apolipoproteins
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cholesteryl
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high-density
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triglyceride
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esterification
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apoa-i
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atherosclerosis
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lipase
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esterify
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low-density
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coronary
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cardiovascular
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hdl-cholesterol
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unesterified
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opacity
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apoproteins
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hypercholesterolemia
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corneal
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discoidal
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atherogenic
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subfractions
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hdl-associated
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triglyceride-rich
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apoc-iii
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postheparin
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synthesis
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hyperlipoproteinemia
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lysolecithin
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vldl-c
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tg-rich
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dimyristoyl
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antiatherogenic
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b-containing
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normolipidemic
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cholesterol-loaded
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xanthoma
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medicine
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lipoprotein-cholesterol
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chylomicron
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acyl-coa:cholesterol
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lipid-free
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paraoxonase
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apob-containing
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hdl-mediated
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3hcholesterol
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drug development
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lipid-poor
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hypertriglyceridemia
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tangier
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very-low-density
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non-hdl
- 2.3.1.43
- lipoprotein
- hdl
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apolipoproteins
-
cholesteryl
-
high-density
- triglyceride
- esterification
- apoa-i
- atherosclerosis
- lipase
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esterify
-
low-density
- coronary
- cardiovascular
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hdl-cholesterol
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unesterified
- opacity
- apoproteins
- hypercholesterolemia
- corneal
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discoidal
-
atherogenic
-
subfractions
-
hdl-associated
-
triglyceride-rich
- apoc-iii
-
postheparin
- synthesis
- hyperlipoproteinemia
- lysolecithin
-
vldl-c
-
tg-rich
-
dimyristoyl
-
antiatherogenic
-
b-containing
-
normolipidemic
-
cholesterol-loaded
-
xanthoma
- medicine
-
lipoprotein-cholesterol
- chylomicron
-
acyl-coa:cholesterol
-
lipid-free
- paraoxonase
-
apob-containing
-
hdl-mediated
-
3hcholesterol
- drug development
-
lipid-poor
- hypertriglyceridemia
- tangier
-
very-low-density
-
non-hdl
Reaction
Synonyms
acyltransferase, lecithin-cholesterol, cholesterol transacyltransferase, LAT, LCAT, lecithin cholesterol acyl transferase, lecithin cholesterol acyltransferase, lecithin-cholesterol acyl transferase, lecithin-cholesterol acyltransferase, lecithin/cholesterol acyltransferase, lecithin: cholesterol acyltransferase, lecithin:cholesterol acyl-transferase, lecithin:cholesterol acyltransferase, lysolecithin acyltransferase, phospholipid-cholesterol acyltransferase, plasma lecithin-cholesterol acyltransferase, TgLCAT, TGME49_272420
ECTree
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Inhibitors
Inhibitors on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase
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4-(2-aminoethyl)benzenesulfonylfluoride
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complete inhibition at 10 mM of the activity in plasma
alpha2-Macroglobulin
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association of this protein with LCAT inhibits the activity of LCAT, and may have a role in its catabolism
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ceramide phosphate
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stronger physiologic inhibitory effect compared to sphingomyelin
glycated discoidal (A-I)rHDL
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after modification of lipid-free apoA-I arginine, lysine and tryptophan residues by glucose
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Haptoglobin
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binds apolipoprotein A-I and E, via its Hpt beta-subunit, and impairs its stimulation of LCAT, mechanism, overview. The affinity of Hpt for ApoE is higher than that for ApoA-I. Hpt also impairs human hepatoblastoma-derived cell uptake of cholesterol from proteoliposomes containing ApoE or ApoA-I
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Sn-2-Difluoroketone phosphatidylcholine analogues
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IC50 values between 0.5 and 0.028 mM
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unesterified cholesterol-(apo lipoprotein A-I-)HDL
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the unesterified cholesterol is deuterium-labeled
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diisopropyl fluorophosphate
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inhibits also the hydrolysis of platelet-activating factor by LCAT
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heparin and serum albumin inhibit lysolecithin acyltransferase activity
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additional information
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serum albumin inhibits hydrolysis of platelet-activating factor by LCAT
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additional information
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hydroperoxides of lecithin act as competitive inhibitors; LCAT may experience product inhibition
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additional information
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hydroperoxides of lecithin act as competitive inhibitors
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additional information
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interaction between Hpt and ApoE represents a mechanism by which inflammation affects atherosclerosis progression
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additional information
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water samples from Balkan endemic nephropathy, BEN, villages from Serbia and Romania show higher LCAT inhibiting activity compared to deionised water and non-endemic water. Inhibitory effect of the organic compounds found in endemic water supplies can cause secondary LCAT deficiency and provide an ethiopathogenic basis for the development of BEN in the susceptible population, overview
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additional information
persons with normal LCAT alleles are also reported to experience reductions in LCAT activity in conjunction with certain diseases including coronary artery disease, diabetes, kidney disease, rheumatoid arthritis, and anemia
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additional information
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persons with normal LCAT alleles are also reported to experience reductions in LCAT activity in conjunction with certain diseases including coronary artery disease, diabetes, kidney disease, rheumatoid arthritis, and anemia
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additional information
antibody 14F11 does not inhibit the enzyme activity
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additional information
high-density lipoprotein subfraction 2 functions as an inhibitor of the cholesterol esterification reaction
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additional information
antibody 14F11 does not inhibit the enzyme activity
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additional information
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antibody 14F11 does not inhibit the enzyme activity
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