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2.3.1.43: phosphatidylcholine-sterol O-acyltransferase

This is an abbreviated version!
For detailed information about phosphatidylcholine-sterol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.43

Reaction

phosphatidylcholine
+
a sterol
=
1-acylglycerophosphocholine
+
a sterol ester

Synonyms

acyltransferase, lecithin-cholesterol, cholesterol transacyltransferase, LAT, LCAT, lecithin cholesterol acyl transferase, lecithin cholesterol acyltransferase, lecithin-cholesterol acyl transferase, lecithin-cholesterol acyltransferase, lecithin/cholesterol acyltransferase, lecithin: cholesterol acyltransferase, lecithin:cholesterol acyl-transferase, lecithin:cholesterol acyltransferase, lysolecithin acyltransferase, phospholipid-cholesterol acyltransferase, plasma lecithin-cholesterol acyltransferase, TgLCAT, TGME49_272420

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.43 phosphatidylcholine-sterol O-acyltransferase

Inhibitors

Inhibitors on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-diphytanoylphosphatidylcholine
-
competitive inhibitor
1-O-hexadecyl-2-O-oleoylphosphatidylcholine
-
competitive inhibitor
2-mercaptoethanol
-
at high concentration
4-(2-aminoethyl)benzenesulfonylfluoride
-
complete inhibition at 10 mM of the activity in plasma
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
alpha2-Macroglobulin
-
association of this protein with LCAT inhibits the activity of LCAT, and may have a role in its catabolism
-
antibody 25B7
-
apolipoprotein A-II
-
-
-
apolipoprotein C-2
-
inhibitor in high concentration
-
carnitine
-
-
castanospermine
-
reduces the maximum reaction velocity but not the Km
ceramide phosphate
-
stronger physiologic inhibitory effect compared to sphingomyelin
chlorpromazine
-
-
cholesteryl ester transfer protein
-
56% inhibition of the activity in plasma
-
cysteine
-
-
deoxynojirimycin
-
reduces the maximum reaction velocity but not the Km
diisopropyl fluorophosphate
dithiothreitol
-
at high concentration
DTNB
-
83% inhibition at 1.4 mM of the activity in plasma
glycated discoidal (A-I)rHDL
-
after modification of lipid-free apoA-I arginine, lysine and tryptophan residues by glucose
-
Haptoglobin
-
binds apolipoprotein A-I and E, via its Hpt beta-subunit, and impairs its stimulation of LCAT, mechanism, overview. The affinity of Hpt for ApoE is higher than that for ApoA-I. Hpt also impairs human hepatoblastoma-derived cell uptake of cholesterol from proteoliposomes containing ApoE or ApoA-I
-
lysolecithin
-
inhibition of LCAT activity
lysophosphatidylcholine
-
both enantiomers, inhibition reversed by albumin
methyldeoxynojirimycin
-
reduces the maximum reaction velocity but not the Km
p-hydroxymercuribenzoate
Phenylarsenoxide derivatives
-
-
phenylmethylsulfonyl fluoride
reduced glutathione
-
-
Serum albumin
-
inhibits LAT activity
-
Sn-2-Difluoroketone phosphatidylcholine analogues
-
IC50 values between 0.5 and 0.028 mM
-
sphingomyelin
Triton X-100
-
inhibition reversed by albumin
tunicamycin
-
reduces the maximum reaction velocity but not the Km
unesterified cholesterol-(apo lipoprotein A-I-)HDL
-
the unesterified cholesterol is deuterium-labeled
-
additional information
-