2.3.1.43: phosphatidylcholine-sterol O-acyltransferase
This is an abbreviated version!
For detailed information about phosphatidylcholine-sterol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.43
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2.3.1.43
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lipoprotein
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hdl
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apolipoproteins
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cholesteryl
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high-density
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triglyceride
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esterification
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apoa-i
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atherosclerosis
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lipase
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esterify
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low-density
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coronary
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cardiovascular
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hdl-cholesterol
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unesterified
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opacity
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apoproteins
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hypercholesterolemia
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corneal
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discoidal
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atherogenic
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subfractions
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hdl-associated
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triglyceride-rich
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apoc-iii
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postheparin
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synthesis
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hyperlipoproteinemia
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lysolecithin
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vldl-c
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tg-rich
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dimyristoyl
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antiatherogenic
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b-containing
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normolipidemic
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cholesterol-loaded
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xanthoma
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medicine
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lipoprotein-cholesterol
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chylomicron
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acyl-coa:cholesterol
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lipid-free
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paraoxonase
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apob-containing
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hdl-mediated
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3hcholesterol
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drug development
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lipid-poor
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hypertriglyceridemia
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tangier
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very-low-density
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non-hdl
- 2.3.1.43
- lipoprotein
- hdl
-
apolipoproteins
-
cholesteryl
-
high-density
- triglyceride
- esterification
- apoa-i
- atherosclerosis
- lipase
-
esterify
-
low-density
- coronary
- cardiovascular
-
hdl-cholesterol
-
unesterified
- opacity
- apoproteins
- hypercholesterolemia
- corneal
-
discoidal
-
atherogenic
-
subfractions
-
hdl-associated
-
triglyceride-rich
- apoc-iii
-
postheparin
- synthesis
- hyperlipoproteinemia
- lysolecithin
-
vldl-c
-
tg-rich
-
dimyristoyl
-
antiatherogenic
-
b-containing
-
normolipidemic
-
cholesterol-loaded
-
xanthoma
- medicine
-
lipoprotein-cholesterol
- chylomicron
-
acyl-coa:cholesterol
-
lipid-free
- paraoxonase
-
apob-containing
-
hdl-mediated
-
3hcholesterol
- drug development
-
lipid-poor
- hypertriglyceridemia
- tangier
-
very-low-density
-
non-hdl
Reaction
Synonyms
acyltransferase, lecithin-cholesterol, cholesterol transacyltransferase, LAT, LCAT, lecithin cholesterol acyl transferase, lecithin cholesterol acyltransferase, lecithin-cholesterol acyl transferase, lecithin-cholesterol acyltransferase, lecithin/cholesterol acyltransferase, lecithin: cholesterol acyltransferase, lecithin:cholesterol acyl-transferase, lecithin:cholesterol acyltransferase, lysolecithin acyltransferase, phospholipid-cholesterol acyltransferase, plasma lecithin-cholesterol acyltransferase, TgLCAT, TGME49_272420
ECTree
2.3.1.43 phosphatidylcholine-sterol O-acyltransferaseAdvanced search results
results (
results (Specific Activity
Specific Activity on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase
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SPECIFIC ACTIVITY [µmol/min/mg] 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
0.01
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in cholesterol-lecithin vesicles activated with apolipoprotein A1, at 37°C and pH 7.1
0.14
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in cholesterol-lecithin vesicles activated with rat apolipoprotein A1
0.217
purified recombinant enzyme, pH 7.4, 37°C, substrates are 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dehydroergosterol
0.56
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in cholesterol-lecithin vesicles activated with human apolipoprotein A1
0.57
0.867
purified recombinant enzyme, pH 7.4, 37°C, substrates are 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and cholesterol
additional information
0.57
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in cholesterol-lecithin vesicles activated with apolipoprotein A1
additional information
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enzyme activity in plasma from healthy buffaloes, and from buffaloes suffering ketosis or haemoglobinuria, overview
additional information
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plasma LCAT activities in dogs fed with diets differing in starch type or low-glycemic index, and oil type or triacylglycerol, overview
additional information
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recombinant enzyme is half as enzymatically active as plasma LCAT
additional information
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acyltransferase and esterase activities of several truncated recombinant enzymes
additional information
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LCAT activity for several phosphatidylcholine analogs with different chain insaturation
additional information
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activity of the wild-type and two naturally occurring mutant enzymes
additional information
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patients with Alzheimer's disease have lower LCAT activity in cerebrospinal fluid
additional information
activities produced by different lung cell clones expressing the enzyme
additional information
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activities produced by different lung cell clones expressing the enzyme
additional information
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activity with 80 and 93 A HDL particles, and with wild-type and different mutant of apolipoprotein A-I, overview
additional information
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cholesterol esterification and phospholipase A2 activities of wild-type and mutant enzymes with different substrates, overview
additional information
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activity of LCAT in men with cardiovascular disease, CVD, compared to healthy men, overview. Plasma LCAT activity is 5% higher in CVD cases in association with higher total cholesterol, non-HDL cholesterol and triglycerides, re-adjusted incident CVD is increased with higher LCAT activity, overview
additional information
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LCAT activity in parallel with HDL2 and HDL3 amounts and composition in pregnancy induced hypertension and chronic hypertensive mothers and in their small newborns, overview
additional information
enzyme activities with apolipoprotein A-I and Apo AI-derived peptides DRV, KLL, and VLES, overview
additional information
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enzyme activities with apolipoprotein A-I and Apo AI-derived peptides DRV, KLL, and VLES, overview
additional information
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lipid accumulation in wild-type and LCAT-/- mutant strains, overview
additional information
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serine palmitoyltransferase deficient mice, and sphingomyelin synthase deficient mice, both of which have below normal sphingomyelin (SM)/phosphatidylcholine (PC) ratios, show significantly elevated LCAT activities when assayed with the endogenous substrates. LDL receptor knockout mice, and apo E knockout mice, both of which have high SM/PC ratios, have reduced LCAT activities
additional information
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diabetic pregnant rats, Isio-4-fed, show a significant reduction of serum LCAT activity compared to control rats. Isio-4-fed macrosomic pups present a significant increase in serum LCAT activity compared to controls. EPAX diet significantly increases LCAT activity in diabetic dams, whlie it induces a decrease in this activity in macrosomic pups
