2.3.1.46: homoserine O-succinyltransferase

This is an abbreviated version!
For detailed information about homoserine O-succinyltransferase, go to the full flat file.

Reaction

Synonyms

homoserine O-succinyltransferase, homoserine O-transsuccinylase, homoserine succinyltransferase, homoserine transsuccinylase, homoserine-O-succinyltransferase, HST, HTS, MetA, MetA protein, succinyltransferase, homoserine

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.46 homoserine O-succinyltransferase

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Results	in table
8536	AA Sequence
2	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
7	General Information
2	General Stability
14	Inhibitors
6	kcat/KM [mM/s]
4	Ki Value [mM]
56	KM Value [mM]
3	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
45	Organism
7	Pathway
7	PDB ID
5	pH Optimum
6	pH Range
70	Protein Variants
6	Purification (Commentary)
5	Reaction
1	Reaction Type
18	Reference
2	Source Tissue
7	Specific Activity [micromol/min/mg]
28	Substrates and Products (Substrate)
2	Subunits
24	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
40	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.3.1.46 - homoserine O-succinyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

glutaryl-CoA + L-homoserine

CoA + O-glutaryl-L-homoserine

Escherichia coli

-

-

487046

-

-

r

succinyl-CoA + D-homoserine

CoA + O-succinyl-D-homoserine

Escherichia coli

-

-

487046

-

-

r

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

19 entries

additional information

?

-

4 entries

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

487043

-

487043

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

487044

-

487044

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

487045

-

487045

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

671413, 671625, 672232, 701784

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

487046

-

487046

r

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

P07623

-

735854, 737132

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

737132

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

P07623

-

755666, 757283

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

-

757283

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

involved in cystathionine and methionine biosynthesis

487043

-

487043

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

involved in cystathionine and methionine biosynthesis

487045

-

487045

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

involved in cystathionine and methionine biosynthesis

487046

-

487046

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

a step in biosynthesis and regulation of methionine, overview

671413

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli

-

step in the biosynthetic pathways of methionine and S-adenosylmethionine, overview

672232

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli W3110 / ATCC 27325

-

-

671413

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Escherichia coli W3110 / ATCC 27325

-

a step in biosynthesis and regulation of methionine, overview

671413

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Geobacillus kaustophilus

-

-

701784

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Geobacillus kaustophilus KCTC 3397

-

-

701784

-

-

?

succinyl-CoA + L-homoserine

CoA + O-succinyl-L-homoserine

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

487045

-

487045

?

additional information

?

-

Escherichia coli

-

3-amino-1-propanol, L-serine, and L-threonine are poor substrates

487046

-

-

?

additional information

?

-

Escherichia coli

-

no activity with acetyl-CoA, propionyl-CoA, butyryl-CoA, crotonyl-CoA, malonyl-CoA, and gamma-hydroxybutyric acid, and gamma-aminobutyric acid

487046

-

-

?

additional information

?

-

Escherichia coli

-

the enzyme is important in regulation of Met biosynthesis and metabolism, metA expression is regulated by the methionine repressor metJ, MetJ and MetA enzyme mutations lead to pathway deregulation and excess methionine production and excretion from the cell, overview

671413

-

-

?

additional information

?

-

Escherichia coli W3110 / ATCC 27325

-

the enzyme is important in regulation of Met biosynthesis and metabolism, metA expression is regulated by the methionine repressor metJ, MetJ and MetA enzyme mutations lead to pathway deregulation and excess methionine production and excretion from the cell, overview

671413

-

-

?