2.3.1.47: 8-amino-7-oxononanoate synthase
This is an abbreviated version!
For detailed information about 8-amino-7-oxononanoate synthase, go to the full flat file.
Word Map on EC 2.3.1.47
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2.3.1.47
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biotin
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pimeloyl-coa
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dethiobiotin
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plp-dependent
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aldimine
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sphaericus
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tympanometric
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pyridoxal-5'-phosphate-dependent
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alpha-oxoamine
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2-amino-3-ketobutyrate
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agriculture
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medicine
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drug development
- 2.3.1.47
- biotin
- pimeloyl-coa
- dethiobiotin
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plp-dependent
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aldimine
- sphaericus
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tympanometric
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pyridoxal-5'-phosphate-dependent
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alpha-oxoamine
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2-amino-3-ketobutyrate
- agriculture
- medicine
- drug development
Reaction
Synonyms
7,8-diaminopelargonic acid aminotransferase, 7-KAP synthetase, 7-keto-8-aminopelargonate synthase, 7-keto-8-aminopelargonate synthetase, 7-keto-8-aminopelargonic acid synthase, 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, 7-oxo-8-aminononanoate synthase, 8-amino-7-oxononanoate synthase, 8-amino-7-oxopelargonate synthase, AON synthase, AONS, AOP synthase, AtbioF, BioF, bioF protein, DAPA AT, KAPA synthase, KAPA synthetase, KAPAS, More, SxtA, synthase, 7-oxo-8-aminononanoate, synthetase, 7-keto-8-aminopelargonate
ECTree
2.3.1.47 8-amino-7-oxononanoate synthaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.3.1.47 - 8-amino-7-oxononanoate synthase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2-amino-3-hydroxy-2-methylnonadioic acid
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competitive, transition state analogue
2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
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2-[(trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
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3-([4-[(2-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
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3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
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3-([4-[(3,5-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
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3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
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3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
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3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide
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4-carboxybutyl(1-amino-1-carboxyethyl)phosphonate
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competitive, transition state analogue
5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiine-2,3-dicarbonitrile
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8-amino-7-oxooctanoic acid
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achiral analog of substrate, strong inhibitor of both enzyme forms, binding to active site
methyl 3-[8-(1H-inden-3-yl)-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
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methyl 3-[8-[(4-fluorophenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
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methyl 3-[8-[(4-methylphenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
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N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide
i.e. KHG23844, induces 2.3fold higher L-alanine accumulation in the treated Arabidopsis thaliana plants. 45-day old Arabidopsis thaliana plants are completely killed by the compound. Foliar supplement of 1 mM biotin at 1 and 2 days before KHG23844 application effectively recovers the growth inhibition of plants treated with the inhibitor
N-[dichloro(fluoro)-l4-sulfanyl]-N',N'-dimethyl-N-phenylsulfuric diamide
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N-[dichloro(fluoromethyl)-lambda4-sulfanyl]-N',N'-dimethyl-N-(4-methylphenyl)sulfuric diamide
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trifluoroalanine
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binding structure, irreversible suicide inhibition of the enzyme, involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate, which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct
(R)-8-amino-7-oxononanoic acid
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no inhibition up to 15 microM with 94.6% ee (S)-enantiomer as substrate, beyond that strong inhibitor of both enzyme forms, binding to active site
(R)-8-amino-7-oxononanoic acid
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no inhibition up to 15 microM with 94.6% ee (S)-enantiomer as substrate, beyond that strong inhibitor of both enzyme forms, binding to active site
D-alanine
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competitive; Schiff base formation between D- or L-alanine and pyridoxal-5'-phophate in the active site
triphenyltin acetate
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herbicidal activity (foliar treatment) under greenhouse conditions
additional information
triazolyl phenyl disulfides as 8-amino-7-oxononanoate synthase inhibitors, overview
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additional information
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triazolyl phenyl disulfides as 8-amino-7-oxononanoate synthase inhibitors, overview
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additional information
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concentration above 10 mM of Ca2+, Mg2+, and Mn2+ cause slow precipitation of the enzyme
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additional information
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no inhibition by HgCl2, EDTA, 2,2'-dipyridyl, oxalate, KCN, various amino acids
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additional information
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inhibition mechanism; no inhibition by 8-amino-7-oxo-8-phosphonononanoic acid
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