2.3.1.47: 8-amino-7-oxononanoate synthase
This is an abbreviated version!
For detailed information about 8-amino-7-oxononanoate synthase, go to the full flat file.
Word Map on EC 2.3.1.47
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2.3.1.47
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biotin
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pimeloyl-coa
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dethiobiotin
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plp-dependent
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aldimine
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sphaericus
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tympanometric
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pyridoxal-5'-phosphate-dependent
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alpha-oxoamine
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2-amino-3-ketobutyrate
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agriculture
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medicine
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drug development
- 2.3.1.47
- biotin
- pimeloyl-coa
- dethiobiotin
-
plp-dependent
-
aldimine
- sphaericus
-
tympanometric
-
pyridoxal-5'-phosphate-dependent
-
alpha-oxoamine
-
2-amino-3-ketobutyrate
- agriculture
- medicine
- drug development
Reaction
Synonyms
7,8-diaminopelargonic acid aminotransferase, 7-KAP synthetase, 7-keto-8-aminopelargonate synthase, 7-keto-8-aminopelargonate synthetase, 7-keto-8-aminopelargonic acid synthase, 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, 7-oxo-8-aminononanoate synthase, 8-amino-7-oxononanoate synthase, 8-amino-7-oxopelargonate synthase, AON synthase, AONS, AOP synthase, AtbioF, BioF, bioF protein, DAPA AT, KAPA synthase, KAPA synthetase, KAPAS, More, SxtA, synthase, 7-oxo-8-aminononanoate, synthetase, 7-keto-8-aminopelargonate
ECTree
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Reaction
Reaction on EC 2.3.1.47 - 8-amino-7-oxononanoate synthase
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
binding study of L-alanine and D-alanine to the enzyme
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
binding study of L-alanine and D-alanine to the enzyme
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
Schiff base formation between D- or L-alanine and pyridoxal-5'-phophate in the active site
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
binding of pimeloyl-CoA causes a conformational change in the active site
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism, formation of the pyridoxal-phosphate-stabilized carbanion by abstraction of the C2-H proton of the alanine-pyridoxal-phosphate aldimine, followed by acylation and decarboxylation
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
reaction mechanism could be shared by all alpha-oxoamine synthases
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
analysis of the reaction mechanism via an enzyme-bound intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, presence of multiple catalytic residues in the Escherichia coli enzyme
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
detailed catalytic reaction mechanism, overview
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
formation of an external intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, preference for L-alanine
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pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
via an AtbioF-PLP internal aldimine complex, i.e. a Schiff base formed between PLP and a Lys residue in the protein