2.3.1.48: histone acetyltransferase
This is an abbreviated version!
For detailed information about histone acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.48
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2.3.1.48
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rhythm
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oscillation
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suprachiasmatic
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chromatin
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entrain
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night
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scn
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sleep
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melatonin
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drosophila
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diurnal
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pacemaker
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locomotor
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light-dark
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nuclei
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deacetylases
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pineal
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morning
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photoperiodic
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retinal
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draw
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hypothalamus
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hdacs
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light-induced
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melanogaster
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photoreceptors
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noise
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bayesian
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nocturnal
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evening
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daytime
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deacetylation
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coherent
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co-activator
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oscillatory
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dementia
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transactivation
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flies
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neuropeptide
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wake
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schedule
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24-hour
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pulses
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circuit
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medicine
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lengthen
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molecular biology
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trichostatin
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mood
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verbal
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neuropsychological
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drug development
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tick
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analysis
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pharmacology
- 2.3.1.48
- rhythm
-
oscillation
-
suprachiasmatic
- chromatin
-
entrain
-
night
- scn
- sleep
- melatonin
- drosophila
-
diurnal
-
pacemaker
-
locomotor
-
light-dark
- nuclei
- deacetylases
-
pineal
-
morning
-
photoperiodic
- retinal
-
draw
- hypothalamus
- hdacs
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light-induced
- melanogaster
- photoreceptors
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noise
-
bayesian
-
nocturnal
-
evening
-
daytime
-
deacetylation
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coherent
-
co-activator
-
oscillatory
- dementia
-
transactivation
- flies
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neuropeptide
-
wake
-
schedule
-
24-hour
-
pulses
-
circuit
- medicine
-
lengthen
- molecular biology
-
trichostatin
-
mood
-
verbal
-
neuropsychological
- drug development
- tick
- analysis
- pharmacology
Reaction
Synonyms
AAPatA, acetyltransferase, histone, Ada2/Ada3/Gcn5 complex, AIB1, amino acid sensing acetyltransferase, AmiPatA, Amir 5672, ARD1, ARD1 acetyltransferase, arginine methyltransferase A, arginine methyltransferase B, arrest defective 1, arrest defective protein 1 acetyltransferase, At3g14980, ATAC2, ATase1, ATase2, cAMP-regulated protein lysine acetyltransferase, Cbp, CBP histone acetyltransferase, CBP/p300, chameau, circadian locomoter output cycles protein kaput, CLOCK, CREB binding protein, CREB-binding protein, CREBBP, east1, ELO3, ELONGATA3, elongator protein 3, ELP3, enhancer-of-asymmetric leaves-two1, Enok, EP300, Esa1, factor acetyltransferase, FAT, Gcn5, GCN5 family KAT, Gcn5 HAT, GCN5 lysine acetyltransferase, GCN5 N acetyltransferase 5, Gcn5 related N-acetyltransferase, GCN5-like acetyltransferase, GCN5-like enzyme, GCN5-related N-acetyltransferase, Gcn5/PCAF histone acetyltransferase, GCN5b, GCN5L2, general control non-derepressible 5, general control non-repressed protein5, general control nonderepressible 5, general control nonrepressed-protein 5, general control of amino acid synthesis 5, GNAT, GNAT-related histone acetyltransferase complex, GTF3C4, H4 lysine acetyltransferase, HAC1, HAG1, HAG3, HAG4, HAG5, HAM1, HAM2, hARD1, HAT, HAT-B, HAT-B complex, Hat1, Hat1p, Hat2, HatB3.I, HBO1, histone (H4 K16) acetyltransferase, histone acetokinase, histone acetyl transferase, histone acetylase, histone acetyltransferase, histone acetyltransferase 1, histone acetyltransferase AtGCN5, histone acetyltransferase B, histone acetyltransferase Tip60, histone acetyltransferase-1, histone acetyltransferases, histone H3 acetyltransferase, histone H4 acetyltransferase, histone H4 lysine 16 acetyltransferase, histone transacetylase, histone/protein lysine acetyltransferase, HIV-1 Tat-interactive protein, hMOF, Hpa2, Hpa3, human acetylase binding to ORC1, Idm1, K (lysine) acetyltransferase 8, K(lysine) acetyltransferase 8, KAT, KAT10, KAT11, KAT12, KAT13A, KAT13B, KAT13C, KAT13D, KAT2, Kat2A, KAT2A/GCN5, Kat2b, KAT3A, KAT3B, KAT4, KAT5, KAT6, KAT6A, KAT6B, KAT7, KAT8, KAT9, Lsy-12, lysine acetyltransferase, lysine acetyltransferase 2, lysine acetyltransferase 2A, lysine acetyltransferase 2B, lysine acetyltransferase 5, lysine acetyltransferase 8, lysine acetyltransferase complex, lysine acetyltransferase p300, lysine acetyltransferases, lysine-acetyltransferase, Mof, monocytic leukemia zinc finger, monocytic leukemia zinc finger protein, More, Morf, MORF histone acetyltransferase, MOZ, MOZ histone acetyltransferase, Moz related factor, Mst1, MtPat, Myb-binding protein 1A, MYBBP1A, MYST, MYST protein lysine acetyltransferase, MYST-related histone acetyltransferase complex, MYST1, MYST2, MYST3, MYST4, N(alpha)-acetyltransferase 10, N-acetyltransferase, N-terminal acetyltransferase, NAA10, NAT, NAT4, NCoA-1, NCoA-3, NCOAT, Nepsilon-lysine acetyltransferase, NuA4, NuA4 histone acetyltransferase, nuclear cytoplasmicO-GlcNAcase and acetyltransferase, nuclear receptor coactivator 1, nuclear receptor coactivator 3, nucleosome-histone acetyltransferase, Nut1, p/CAF, P/CAF histone acetyltransferase, p160, p300, p300 HAT, p300 histone acetyltransferase, p300/CBP, p300/CBP associated factor, p300/CBP histone acetyltransferase, P300/CBP-associated factor, p300/CBP-associated factor (pCAF), p300HAT, PA4534, Pat, PCAF, PCAF histone acetyltransferase, PF11_0192, PfGCN5, PfGCN5 HAT, Piccolo NuA4 complex, protein acetyl-transferase, protein acetyltransferase, Qkf, regulator of Ty1 transposition protein 109, RmtA, RmtB, RPD3, Rtt109, Rv0998, SAS complex, Sas2, Sas3, SRC1, SRC3, Sven 0867, SvePatA, TAF, TAF1, Tat interacting protein of 60 kDa, Tat-interactive protein, 60 kDa, TBP1, TFIIIC90, tGCN5, TgGCN5b, TgMYST-B, Tip60, tumor suppressor histone H3 lysine 23 acetyltransferase, type B histone acetyltransferase, YfmK, zMoz
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2.3.1.48 histone acetyltransferaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.48 - histone acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4 acetyl-CoA + histone H4
4 CoA + tetraacetylhistone H4
-
-
NuA4 randomly acetylates free and nucleosomal H4, with a small preference for lysines 5, 8, and 12 over 16
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?
acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1
CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1
-
-
-
-
?
acetyl-CoA + c-Myc
CoA + acetylated c-Myc
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acetylation by Tip60 increases c-Myc protein stability in transfected H-1299 human lung carcinoma cells
-
-
?
acetyl-CoA + histone H
CoA + acetylhistone H
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histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway
-
-
?
acetyl-CoA + histone H2A
CoA + acetylhistone H2A
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acetylation at Lys5 by Tip60
-
-
?
acetyl-CoA + N-terminal L-lysyl-[beta-catenin]
CoA + H+ + N-terminal Nalpha-acetyl-lysyl-[beta-catenin]
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-
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ir
acetyl-CoA + N-terminal L-lysyl-[Hsp70]
CoA + H+ + N-terminal Nalpha-acetyl-L-lysyl-[Hsp70]
-
-
-
ir
acetyl-CoA + p50 protein
CoA + acetyl-p50 protein
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acetylation of p50 by p300 independent of shear stress
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-
?
acetyl-CoA + p53
CoA + acetyl-p53
p53 protein-acetylation of the Lys120 residue
-
-
?
acetyl-CoA + p65 protein
CoA + acetyl-p65 protein
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acetylation of p65 by p300 during translocation into the nuclei in response to shear stress
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine40
-
-
-
?
acetyl-CoA + [AuA]-L-lysine125
CoA + [AuA]-N6-acetyl-L-lysine125
lysine residues at positions 75 and 125 of aurora kinase A (AuA) are acetylated by ARD1, mutational analysis with AUA mutant substrates, overview
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-
?
acetyl-CoA + [AuA]-L-lysine75
CoA + [AuA]-N6-acetyl-L-lysine75
lysine residues at positions 75 and 125 of aurora kinase A (AuA) are acetylated by ARD1, mutational analysis with AUA mutant substrates, overview
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-
?
acetyl-CoA + [beta-catenin]-L-lysine
CoA + [beta-catenin]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [CDC6]-L-lysine
CoA + [CDC6]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [connexin 43]-L-lysine
CoA + [connexin 43]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [Foxo1]-L-lysine
CoA + [Foxo1]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H2A]-L-lysine5
CoA + [histone H2A]-N6-acetyl-L-lysine5
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H2B]-L-lysine
CoA + [histone H2B]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H2B]-L-lysine12
CoA + [histone H2B]-N6-acetyl-L-lysine12
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H2B]-L-lysine15
CoA + [histone H2B]-N6-acetyl-L-lysine15
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine18
CoA + [histone H3]-N6-acetyl-L-lysine18
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine20
CoA + [histone H3]-N6-acetyl-L-lysine20
-
-
-
?
acetyl-CoA + [histone H4]-L-lysin16
CoA + [histone H4]-N6-acetyl-L-lysine16
-
-
-
?
acetyl-CoA + [NFkappaB]-L-lysine
CoA + [NFkappaB]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [p27]-L-lysine
CoA + [p27]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [PGC-1alpha]-L-lysine
CoA + [PGC-1alpha]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [PGC-1]-L-lysine
CoA + [PGC-1]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [PTEN]-L-lysine
CoA + [PTEN]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
acetylation of the oncosuppressor protein PTEN on two lysine residues (Lys125 and Lys128)
-
-
?
acetyl-CoA + [STAT3]-L-lysine
CoA + [STAT3]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
androgen receptor + acetyl-CoA
acetylated androgen receptor + CoA
-
receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview
-
-
?
ATM kinase + acetyl-CoA
acetylated ATM kinase + CoA
-
ATM protein kinase regulates the cells response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair, suppression of Tip60 blocks the activation of ATMs kinase activity, ATM autophosphorylation e.g. at Ser1981, and prevents the ATM-dependent phosphorylation of p53 and chk2, inactivation of Tip60 sensitizes cells to ionizing radiation, overview
-
-
?
piccoloNuA4 peptide + acetyl-CoA
acetyl-piccoloNuA4 peptide + CoA
the peptide is part of the physiologic enzme complex, overview
-
-
?
promyelotic leukemia zinc finger gene + acetyl-CoA
acetylated promyelotic leukemia zinc finger gene + CoA
-
-
-
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
important role of the enzyme for chromatin modulating activity
-
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
most likely involved in acetylation of newly synthesized histones in cytoplasm prior to chromatin assembly
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
histone H1 is not acetylated in vivo
-
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
involved in chromatin remodeling and DNA repair
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
histone H1 is not acetylated in vivo
-
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
involved in chromatin remodeling and DNA repair
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone
CoA + acetylhistone
the bifunctional enzyme NCOAT, nuclear cytoplasmic O-GlcNacase and acetyltransferase, may be regulated to reduce the state of glycosylation of transcriptional activators while increasing the acetylation of histones to allow for concerted activation of eukaryotic gene transcription
-
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
involved in dynamic equilibrium of core histone acetylation
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
Esa1 protein is involved in cell cycle regulation
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
involved in chromatin remodeling and DNA repair
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
histone H3 is the preferred substrate
-
r
acetyl-CoA + histone
CoA + acetylhistone
-
neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
histone acetylation on Lys16 by Sas2
-
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA
-
?
acetyl-CoA + histone
CoA + acetylhistone
-
the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling
-
?
acetyl-CoA + histone H3
CoA + acetyl-histone H3
-
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
acetylation at Lys9
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
acetylation of Lys9, Lys14, Lys18, Lys23, Lys27, Lys36, and Lys37
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
-
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
acetylation of Lys23
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
regulation, detailed overview. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an NF-kappaB-signaling code and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner, overview
-
-
r
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
CBP binds and acetylates histones at neural promoters, and regulates Corpus Callosum development. CBP binds to neuronal and glial promoters and globally promotes histone acetylation in the embryonic cortex, e.g. the beta-actin promoter, overview
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
acetylation of Lys56
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
Rtt109 association with distinct histone chaperones directs substrate selection between N-terminal lysines, H3K9, H3K23, and those within the histone fold domain, H3K56
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56. RTT109 has functions in addition to maintaining genome stability
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
acetylation at Lys18
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
acetylation of Lys56
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
-
acetylation of Lys14 by tGCN5 in the consensus sequence QTARKSTGGK14APRKLASK
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
preferred substrate
-
-
?
acetyl-CoA + histone H3
CoA + acetylhistone H3
preferred substrate
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
acetylation at Lys14
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
RmtA is specific for histone H4 with Arg3 as the methylation site. Methylation of histone H4 by recombinant RmtA affects the acetylation by p300/CBP, supporting aninterrelation of histone methylation and acetylation in transcriptional regulation. Important role of the enzyme for chromatin modulating activity
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
Mof is required for sex chromosome dosage compensation acting in the MSL complex, which also contains Msl1-3, Mle, and RNA, to acetylate H4K16 and to increase gene transcription from the single male X chromosome
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
acetylation of Lys5, Lys8, Lys12, and Lys16
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
Hat1 is a primary enzyme for di-acetylating cytosolic histone H4 at Lys5 and Lys12 in the cytosol
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
-
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
specific acetylation of Lys16, reversible acetylation of histones play an important role in regulation of chromatin structure and function. HMOF has a role in DNA damage responseduring cell cycle progression
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
HBO1 is an H4-specific histone acetylase, and is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is essential for DNA licensing of replication origins, where it controls H4 acetylation at the origins. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
HBO1 regulates global histone H4 acetylation
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on Lys16, while NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on Lys5 and Lys8
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
MYST1 specificity to Lys16 of histone H4 is not absolute, because in experiments in vitro the protein is also able to acetylate histones H3 and H2A, whereas in vivo only modification of histone H4 is specific. Acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B. All human autosomes are susceptible to histone H4 acetylation by Lys16 residue and acetyltransferase MYST1
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
acetylation of Lys16
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
acetylation of Lys16
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
Mof is solely responsible for H4K16 acetylation in mouse blastocysts. Tip60 plays essential roles in cell cycle progression in vitro
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
acetylation of histone H4 by NuA4 is required for the cellular resistance to spindle stress. The NuA4 histone acetyltransferase subunit Yaf9, is required for the cellular response to spindle stress in yeast
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
exclusively acetylates of Lys16 of histone H4, the enzyme is required for bulk of H4 lysine 16 acetylation in vivo, role of SAS complex in antagonizing the speading of Sir proteins at silent loci in Saccharomyces cerevisiae
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
the level of HAT-B-dependent acK12H4 may be very low under normal growth condition
-
-
?
acetyl-CoA + histone H4
CoA + acetylhistone H4
-
both Lys12 and Lys5 of soluble, non-chromatin-bound histone H4 are in vivo targets of acetylation for the yeast HAT-B enzyme. Lys12/Lys5-acetylated histone H4 is bound to the HAT-B complex in the soluble cell fraction. Exchange of Lys for Arg at position 12 of histone H4 do not interfere with histone H4 association with the complex, but prevented acetylation on Lys5 by the HAT-B enzyme, in vivo as well as in vitro
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [ATM]-L-lysine
CoA + [ATM]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [ATM]-L-lysine
CoA + [ATM]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [c-myc]-L-lysine
CoA + [c-myc]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [c-myc]-L-lysine
CoA + [c-myc]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [DNMT1]-L-lysine
CoA + [DNMT1]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [DNMT1]-L-lysine
CoA + [DNMT1]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [E2F1]-L-lysine
CoA + [E2F1]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [E2F1]-L-lysine
CoA + [E2F1]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [EGR2]-L-lysine
CoA + [EGR2]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [HBsu]-L-lysine
CoA + [HBsu]-N6-acetyl-L-lysine
essential histone-like protein HBsu contains seven acetylation sites in vivo, mutational analysis using mutants hbsK86Q, hbsK41Q, hbsK3Q, hbsK41R, and hbsK37R
-
-
?
acetyl-CoA + [HBsu]-L-lysine
CoA + [HBsu]-N6-acetyl-L-lysine
essential histone-like protein HBsu contains seven acetylation sites in vivo, mutational analysis using mutants hbsK86Q, hbsK41Q, hbsK3Q, hbsK41R, and hbsK37R
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine
CoA + [histone H3]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
-
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine14
CoA + [histone H3]-N6-acetyl-L-lysine14
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine23
CoA + [histone H3]-N6-acetyl-L-lysine23
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine23
CoA + [histone H3]-N6-acetyl-L-lysine23
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine56
CoA + [histone H3]-N6-acetyl-L-lysine56
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine56
CoA + [histone H3]-N6-acetyl-L-lysine56
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
-
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
-
-
-
?
acetyl-CoA + [histone H3]-L-lysine9
CoA + [histone H3]-N6-acetyl-L-lysine9
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine
CoA + [histone H4]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine12
CoA + [histone H4]-N6-acetyl-L-lysine12
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine12
CoA + [histone H4]-N6-acetyl-L-lysine12
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine12
CoA + [histone H4]-N6-acetyl-L-lysine12
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine12
CoA + [histone H4]-N6-acetyl-L-lysine12
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine12
CoA + [histone H4]-N6-acetyl-L-lysine12
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine16
CoA + [histone H4]-N6-acetyl-L-lysine16
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine16
CoA + [histone H4]-N6-acetyl-L-lysine16
main substrate
-
-
?
acetyl-CoA + [histone H4]-L-lysine16
CoA + [histone H4]-N6-acetyl-L-lysine16
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine16
CoA + [histone H4]-N6-acetyl-L-lysine16
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine16
CoA + [histone H4]-N6-acetyl-L-lysine16
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
main substrate
-
-
?
acetyl-CoA + [histone H4]-L-lysine16
CoA + [histone H4]-N6-acetyl-L-lysine16
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine5
CoA + [histone H4]-N6-acetyl-L-lysine5
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine5
CoA + [histone H4]-N6-acetyl-L-lysine5
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine5
CoA + [histone H4]-N6-acetyl-L-lysine5
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine5
CoA + [histone H4]-N6-acetyl-L-lysine5
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine5
CoA + [histone H4]-N6-acetyl-L-lysine5
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine8
CoA + [histone H4]-N6-acetyl-L-lysine8
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine8
CoA + [histone H4]-N6-acetyl-L-lysine8
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine8
CoA + [histone H4]-N6-acetyl-L-lysine8
-
-
-
?
acetyl-CoA + [histone H4]-L-lysine8
CoA + [histone H4]-N6-acetyl-L-lysine8
-
-
-
?
acetyl-CoA + [p53]-L-lysine
CoA + [p53]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [p53]-L-lysine
CoA + [p53]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [p53]-L-lysine120
CoA + [p53]-N6-acetyl-L-lysine120
-
-
-
?
acetyl-CoA + [p53]-L-lysine120
CoA + [p53]-N6-acetyl-L-lysine120
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
endogenous GCN5 and EGR2 in iNKT cells
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
endogenous GCN5 and EGR2 in iNKT cells
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [TIP5]-L-lysine
CoA + [TIP5]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [TIP5]-L-lysine
CoA + [TIP5]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
acetyl-CoA + [TRRAP]-L-lysine
CoA + [TRRAP]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [TRRAP]-L-lysine
CoA + [TRRAP]-N6-acetyl-L-lysine
O15516, O95251, P21675, Q15788, Q8WYB5, Q92793, Q92794, Q92830, Q92831, Q92993, Q9BQG0, Q9H7Z6, Q9H9T3, Q9UKN8, Q9Y6Q9
-
-
-
?
histone + acetyl-CoA
acetyl-histone + CoA
-
histone acetylation is an important posttranslational modification correlated with gene activation, the HAC1 is involved in the regulation of flowering time via repression of flowering locus C, the enzyme participates in many physiological processes, including proliferation, differentiation, and apoptosis
-
-
?
histone + acetyl-CoA
acetyl-histone + CoA
-
phosphorylation of p300 at Ser1834 by the kinase Akt is essential for its histone acetyltransferase and transcriptional activity
-
-
?
histone + acetyl-CoA
acetyl-histone + CoA
-
key enzyme in post-translational modification of histones associated with transcriptionally active genes
-
-
?
histone H3 + acetyl-CoA
acetyl-histone H3 + CoA
-
acetylation of Lys9, and Lys14
-
-
?
histone H3 + acetyl-CoA
acetyl-histone H3 + CoA
-
acetylation of Lys9, and Lys14
-
-
?
histone H3 + acetyl-CoA
acetyl-histone H3 + CoA
-
the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview
-
-
?
histone H4 + acetyl-CoA
acetyl-histone H4 + CoA
-
acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation
-
-
?
additional information
?
-
-
affects the inflorescence meristem and stamen development in Arabidopsis thaliana
-
-
?
additional information
?
-
-
histone acetylation and deacetylation is an epigenetic mechanism in volved in regulation of mIRNA production. GCN5 has a general repressive effect on microRNAs, miRNAs, and it targets a subset of MIRNA genes, GCN5 is required for acetylation of histone H3 lysine 14 at these loci, overview
-
-
?
additional information
?
-
isoform GCN5 is not the enzyme responsible for histone acetylation at cold-regulated genes COR promoters during cold acclimation
-
-
?
additional information
?
-
-
GCN5 directly targets HSFA3 and UVH6 and affects their H3K9 and H3K14 acetylation levels
-
-
?
additional information
?
-
-
Tip60, in complex with homologues of the mammalian Tip60 complex, exhibits functional redundancy with two other groups of genes, known as synthetic multivulva A and B genes, synMUV. Therefore, the genes encoding proteins of the Tip60 complex are termed class C synMUV genes. SynMUV A and B counteract EGF to Ras to MAPK signaling and the Tip60 complex is a chromatin-modifying complex
-
-
?
additional information
?
-
-
a homologue of Moz, zMoz, occurs in zebrafish to perform a potential Moz function in the trunk region
-
-
?
additional information
?
-
-
a homologue of Moz, zMoz, occurs in zebrafish to perform a potential Moz function in the trunk region
-
-
?
additional information
?
-
-
the enzyme plays a role in chromatin structure and gene expression regulation as a catalytic component of multiprotein complexes, some of which also contain Ada2-type transcriptional coactivators
-
-
?
additional information
?
-
-
MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. Interactions between MSL1 and MYST1 within the MSL complex in Drosophila melanogaster, the compensasome includes proteins MSL1, MSL2, MSL3, MLE, MOF, a histone acetyltransferase homologous to MYST1, JIL1, and two non-coding RNA: roX1 and roX2, structure and function of the compensasome, detailed overview. Cell interactome fragments including protein homologs of hampin and MYST1, overview
-
-
?
additional information
?
-
-
histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview
-
-
?
additional information
?
-
-
enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors
-
-
?
additional information
?
-
-
MOZ and MORF genes are rearranged by chromosome abnormalities associated with several types of leukemia
-
-
?
additional information
?
-
-
MYST-related histone acetyltransferase complex Tip60 also acts as a transcriptional coactivator in several systems including class I nuclear hormone receptors, NF-kappaB and at the superoxide dismutase gene. Tip 60 has been implicated in Alzheimer disease because it stimulates transcription when asociated with the cleaved cytoplasmic tail fragment of the amyloid-beta precursor protein
-
-
?
additional information
?
-
-
Tip60 plays a role in the control of cell-related events
-
-
?
additional information
?
-
-
acetylation of proteins by the enzyme plays a critical role in the regulation of gene expression
-
-
?
additional information
?
-
-
androgen Src kinase and PKCd kinase are involved in the regulation of p300 HAT activity via bombesin, overview
-
-
?
additional information
?
-
-
deregulated HAT activity plays a role in the development of a range of cancers
-
-
?
additional information
?
-
-
the enzyme is involved in Sp1 activation of the cyclin D1 promoter, TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G1-to-S-phase progression, regulation, overview
-
-
?
additional information
?
-
-
the histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
-
-
?
additional information
?
-
ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism
-
-
?
additional information
?
-
-
besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity
-
-
?
additional information
?
-
besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity
-
-
?
additional information
?
-
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HBO1 histone acetylase is involved in DNA replication licensing and associates with replication origins, located within the HPRT1 coding sequence, specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor geminin
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HBO1 occurs as a component of a multiprotein complex with histone H3 and H4 acetyltransferase activity in 293 cells. The mammalian complex corresponding to the yeast NuA4 complex contains the MYST HAT Tip60
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in response to DNA damage, Tip60 acetylates ATM, a DNA damage related kinase, allowing for phosphorylation of Chk2 and p53 by ATM. HATs perform a conserved mechanism of acetyl-transfer, where the lysine-containing substrate directly attacks enzyme-bound acetyl-CoA. The ability of HATs to form distinct multi-subunit complexes provide a means to regulate HAT activity by altering substrate specificity, targeting to specific loci, enhancing acetyltransferase activity, restricting access of non-target proteins, and coordinating the multiple enzyme activities of the complex
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increase in eNOS mRNA, caused by shear stress, is completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA
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mechanistically, p300 acts as a transcriptional coactivator through the direct interaction with a diverse set of transcription factors and RNA polymerase II transcription machinery
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MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. MYST1 interacts with WDR5. Cell interactome fragments including protein homologs of hampin and MYST1, overview
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Tip60 is part of the evolutionarily conserved NuA4 complex
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enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300
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GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters
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enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors
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MOZ specifically interacts and associates with transcription factors such as AML1, PU.1, p53, Runx2 and NF-kappaB, functioning as their transcriptional coactivator and cooperatively activating target gene transcription
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ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism
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specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required
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the mammalian complex corresponding to the yeast NuA4 complex contains the MYST HAT Tip60. Myc recruits the Tip60 complex to the chromatin in Rat1 wild-type cells, but not in Rat1 Myc mutant cells. Hbo1 appears to function predominantly in transcriptional repression
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specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required
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the enzyme modulates gene expression in liver nuclei in an epigenetic manner at high blood alcohol levels, no alteratins of MAP kinase levels, overview
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enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors
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MYST-related histone acetyltransferase complex NuA4: required for cell growth, required for p53-dependent transcription activation in yeast, presumably through its Yng2 subunit, homolog of the tumor suppressor ING1. GNAT-related histone acetyltransferase complex SAGA can stimulate Gal4-VP16 activation in a manner dependent on HAT activity. D´SAGA can be recruited by several yeast activators. SAGA is targeted to promoter regions proximal to the activator binding site. Once targeted, SAGA acetylates histone h3 in the vicinity of the promoter. Targeted acetylation by SAGA stabilizes its binding and that of a targeted SWI/SNF chromatin-remodeling complex. SAGA is required for both activation of the yeast ARG1 promoter by Gcn4 activator and repression by the ArgR/Mcm1 repressor complex
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Esa1 is the catalytic subunit of at least two multiprotein complexes, NuA4 and Piccolo NuA4, picNuA4
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HATs perform a conserved mechanism of acetyl-transfer, where the lysine-containing substrate directly attacks enzyme-bound acetyl-CoA. The ability of HATs to form distinct multi-subunit complexes provide a means to regulate HAT activity by altering substrate specificity, targeting to specific loci, enhancing acetyltransferase activity, restricting access of non-target proteins, and coordinating the multiple enzyme activities of the complex
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HBO1, Sas2 and Sas3 are involved in transcriptional repression enhancing Sir1-mediated epigenetic gene silencing. NuA3 and NuA4 complexes contain the MYST HATs Sas3 and Esa1, respectively. Sas2 histone acetylation of H4K16 opposed by Sir2 deacetylation of H4K16 at the euchromatin/heterochromatin interface maintains the boundary between regions of transcriptionally active and silent telomeric chromatin. Esa1 plays a role in maintaining the integrity of the DNA, rather than open chromatin structure and high-level transcriptional activity
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in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22
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Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner
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soluble histone H4 Hat1-dependently acetylated on Lys12 is present in cells arrested at all cell cycle stages, G1, S, G2/M and also G0. Histone H3 seems to be no substrate for the HAT-B complex
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NuA4 targets histone and nonhistone proteins
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NuA4 targets histone and nonhistone proteins
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Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner
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NuA4 targets histone and nonhistone proteins
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Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22, Sc Rad52, the chromatin assembly factor Hip1, Sc Hir1, and the Msc1 protein related to a family of histone demethylases, detailed interaction analysis, overview
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enzyme GCN5b interacts with AP2-domain proteins, apicomplexan plant-like transcription factors, as well as a core complex that includes the co-activator ADA2-A, TFIID subunits, LEO1 polymerase-associated factor (Paf1) subunit, and RRM proteins
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enzyme GCN5b interacts with AP2-domain proteins, apicomplexan plant-like transcription factors, as well as a core complex that includes the co-activator ADA2-A, TFIID subunits, LEO1 polymerase-associated factor (Paf1) subunit, and RRM proteins
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