2.3.1.50: serine C-palmitoyltransferase

This is an abbreviated version!
For detailed information about serine C-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.50

2.3.1.50

sphingolipids

ceramide

myriocin

sphingomyelin

sphingosine

sphingomyelinase

neuropathy

sphingoid

cholesterol

fumonisin

glucosylceramide

sphingosine-1-phosphate

3-ketodihydrosphingosine

corneum

glycosphingolipids

dihydroceramide

dihydrosphingosine

plp-dependent

l-cycloserine

ormdl3

molecular biology

sphingomonas

paucimobilis

transepidermal

charcot-marie-tooth

analysis

ceramide-induced

phytosphingosine

medicine

asmase

aldimine

Reaction

Synonyms

3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating, LCB1, LCB2, LCB2a, LCB2b, More, palmitoyltransferase, serine, serine palmitoyl transferase, serine palmitoyltransferase, serine palmitoyltransferase 1, serine palmitoyltransferase a, serine-palmitoyl transferase, serine-palmitoyltransferase, SPT, SPT1, SPT2, SPT3, SPTase, SPTLC1, SPTLC2, ssSPT, ssSPTa, Tsc3

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.50 serine C-palmitoyltransferase

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Results	in table
17	Activating Compound
1022	AA Sequence
8	Application
1	CAS Registry Number
52	Cloned(Commentary)
54	Cofactor
6	Crystallization (Commentary)
331	Disease/ Diagnostics
9	Expression
50	General Information
14	IC50 Value
84	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
68	KM Value [mM]
73	Localization
5	Metals/Ions
20	Molecular Weight [Da]
93	Natural Substrates/ Products (Substrates)
124	Organism
7	Pathway
49	PDB ID
30	pH Optimum
4	pH Range
3	pH Stability
6	Posttranslational Modification
75	Protein Variants
18	Purification (Commentary)
18	Reaction
17	Reaction Type
109	Reference
1	Renatured (Commentary)
104	Source Tissue
29	Specific Activity [micromol/min/mg]
1	Storage Stability
206	Substrates and Products (Substrate)
39	Subunits
168	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]
2	Temperature Stability [°C]
34	Turnover Number [1/s]

Subunits

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Subunits on EC 2.3.1.50 - serine C-palmitoyltransferase

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dimer

heterodimer

heterotrimer

SPT is a heterodimer of 2 highly-related subunits, LCB1 and LCB2, existing in two isozyme forms LCB2a and LCB2b, associated with a third small activating subunit, either protein ssSPTa and protein ssSPTb, the proteins have a conserved hydrophobic central domain, reside in the membrane and interact with both hLCB1 and hLCB2 subunits, overview,protein ssSPTa and protein ssSPTb are required for maximal enzyme activity. SPT subunit interaction analysis, overview

706542

homodimer

6 entries

monomer

Coccolithovirus

single-chain enzyme, domain structure, overview

674731

octamer

Homo sapiens

results show that functional SPT is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1, SPTLC2 and SPTLC3) with a molecular mass of 480 kDa (gel filtration). The stoichiometry of SPTLC2 and SPTLC3 in this complex is not to be fixed and is changed dynamically in dependence of the tissue specific SPTLC2 and SPTLC3 expression levels. A model of an octameric SPT structure is proposed. By Blue-native-PAGE experiments it is shown that all three SPT subunits (SPTLC1-3) are co-localized within a single SPT complex

671900

oligomer

2 entries

additional information

5 entries