2.3.1.57: diamine N-acetyltransferase

This is an abbreviated version!
For detailed information about diamine N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, acetyltransferase, putrescine, bltD, CpSSAT, diamine acetyltransferase, More, N1-SAT, N1-spermidine/spermine acetyltransferase, N1SSAT, PaiA, putrescine (diamine)-acetylating enzyme, putrescine acetylase, putrescine acetyltransferase, putrescine N-acetyltransferase, SAT, SAT1, SpeG, spermidine /spermine N1-acetyltransferase, spermidine acetyltransferase, spermidine N-acetyltransferase, spermidine N1-acetyltransferase, spermidine-spermine acetyltransferase, spermidine-spermine N1-acetyltransferase, spermidine/spermine acetyltransferase, spermidine/spermine N-acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine/spermine N1-acetyltransferase 1, spermidine/spermine N1-acetyltransferase 2, spermidine/spermine N1-acetyltransferase-1, spermidine/spermine-N 1-acetyltransferase, spermidine/spermine-N1-acetyltransferase, spermidine/spermine-N1-acetyltransferase activity, SSAT, SSAT-1, SSAT-2, SSAT1, SSAT2, SSATX, Ste27, Ta0374, VCA0947

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.57 diamine N-acetyltransferase

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Results	in table
21	Activating Compound
4315	AA Sequence
15	Application
1	CAS Registry Number
41	Cloned(Commentary)
20	Cofactor
13	Crystallization (Commentary)
348	Disease/ Diagnostics
17	Expression
54	General Information
8	General Stability
53	Inhibitors
15	kcat/KM [mM/s]
15	Ki Value [mM]
75	KM Value [mM]
23	Localization
19	Molecular Weight [Da]
123	Natural Substrates/ Products (Substrates)
100	Organism
6	Pathway
115	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
4	Posttranslational Modification
49	Protein Variants
21	Purification (Commentary)
9	Reaction
1	Reaction Type
96	Reference
104	Source Tissue
40	Specific Activity [micromol/min/mg]
6	Storage Stability
277	Substrates and Products (Substrate)
18	Subunits
155	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
19	Turnover Number [1/s]

General Stability

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General Stability on EC 2.3.1.57 - diamine N-acetyltransferase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

N1,N11-bis(ethyl)norspermine completely stabilizes the wild-type enzyme, which is degraded within 90 min in absence of N1,N11-bis(ethyl)norspermine, half-life: 22 min, half-life in presence of N1,N11-bis(ethyl)norspermine: 144 h, while for the mutant L156F half-life is 105 min and 154 min, respectively

Cricetulus griseus

-

662129

N1,N11-diethylnorspermine stabilizes

Mus musculus

-

487267

native protein conformation is unstable, polyamine analogues such as N1,N12-bis(ethyl)spermine greatly stabilize, conformational changes caused by their binding prevent the efficient polyubiquination of enzyme and therefore its degradation

Homo sapiens

-

487268

PMSF and Brij 35 are essential to prevent rapid loss of activity of the enzyme preparation

Ascaris suum

-

487259

sensitive to incubation in dilute solutions, bovine serum albumin, 0.5 mg/ml, stabilizes

Rattus norvegicus

-

487258

unstable enzyme, glycerol 10% v/v or bovine serum albumin, 5 mg/ml, partially stabilizes

[Candida] boidinii

-

487256

unstable enzyme, spermidine stabilizes

Rattus norvegicus

-

487257, 487258