2.3.1.6: choline O-acetyltransferase
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For detailed information about choline O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.6
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2.3.1.6
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cholinergic
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acetylcholine
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nerve
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acetylcholinesterase
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hippocampus
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forebrain
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neurotransmitter
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innervation
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alzheimer
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cortical
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axon
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medial
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muscarinic
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striatum
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neurochemical
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spinal
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retrograde
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maze
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ventral
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basalis
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ganglion
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neurotrophic
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septal
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ngf
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diagonal
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gabaergic
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myenteric
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interneurons
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vacht
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motoneuron
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chat-positive
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afferent
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meynert
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magnocellularis
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presynaptic
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varicosity
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parasympathetic
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non-cholinergic
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preganglionic
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benzilate
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somata
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calretinin
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wga-hrp
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intermediolateral
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broca
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analysis
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amacrine
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ache-positive
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pharmacology
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pedunculopontine
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ibotenic
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diagnostics
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tegmentum
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medicine
- 2.3.1.6
-
cholinergic
- acetylcholine
- nerve
- acetylcholinesterase
- hippocampus
- forebrain
-
neurotransmitter
-
innervation
- alzheimer
- cortical
- axon
-
medial
-
muscarinic
- striatum
-
neurochemical
- spinal
-
retrograde
-
maze
-
ventral
-
basalis
- ganglion
-
neurotrophic
- septal
- ngf
-
diagonal
-
gabaergic
- myenteric
-
interneurons
-
vacht
- motoneuron
-
chat-positive
-
afferent
- meynert
-
magnocellularis
-
presynaptic
-
varicosity
-
parasympathetic
-
non-cholinergic
-
preganglionic
- benzilate
-
somata
-
calretinin
-
wga-hrp
-
intermediolateral
- broca
- analysis
-
amacrine
-
ache-positive
- pharmacology
-
pedunculopontine
-
ibotenic
- diagnostics
- tegmentum
- medicine
Reaction
Synonyms
acetyl CoA:choline-O-acetyltransferase, acetyl-CoA:choline-O-acetyltransferase, acetyltransferase, choline, cChAT, chAcT, ChAT, choline acetyl transferase, choline acetylase, choline acetyltransferase, choline-acetyltransferase, pChAT, peripheral type of choline acetyltransferase
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analysis
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real-time multiplex PCR technique can be carried out in a single tube and can differentiate between the polymorphic sites of the ChAT gene associated with Alzheimers disease
diagnostics
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ChAT is selected as a marker of cholinergicneurons. In the CA1 region of hippocampus of mice, several of the insulin signaling-related proteins are co-located with ChAT, and most double immunoreactive positive cells are pyramidal cells
medicine
pharmacology
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Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced dementia through the induction of choline acetyltransferase expression and inhibition of acetylcholinesterase activity
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a severe case of congenital myasthenia gravis in a Chinese newborn is reported who presents with complete ptosis, severe hypotonia, dysphagia and respiratory insufficiency with recurrent apnea that requires mechanical ventilatory support since birth. The infant has heterozygous mutations in the choline acetyltransferase genes, p.T553N and p.S704P
medicine
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ChAT 2384 A allele is a risk factor for Alzheimers disease and mild cognitive impairment
medicine
investigation of three ChAt gene polymorphisms in schizophrenia. Evidence for an influence of a 5' promoter polymorphism, rs1880676A/G, on susceptibility to the disorder among individuals of Basque origin. Evidence for a similar though less significant, influence for a second polymorphism of putative function, rs3810950
medicine
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promoting ChAT activity and acetylcholine release can lead to treatments for neurodegenerative diseases with cholinergic deficits, such as Alzheimers disease