Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.1.6: choline O-acetyltransferase

This is an abbreviated version!
For detailed information about choline O-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.6

Reaction

acetyl-CoA
+
choline
=
CoA
 +
O-acetylcholine

Synonyms

acetyl CoA:choline-O-acetyltransferase, acetyl-CoA:choline-O-acetyltransferase, acetyltransferase, choline, cChAT, chAcT, ChAT, choline acetyl transferase, choline acetylase, choline acetyltransferase, choline-acetyltransferase, pChAT, peripheral type of choline acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.6 choline O-acetyltransferase

IC50 Value

IC50 Value on EC 2.3.1.6 - choline O-acetyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.007
1-(azepan-1-yl)-3-[(8-ethyl-4a,5-dihydro-4H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]propan-1-one
Homo sapiens
pH 7.4, 37°C
0.0165
1-[2-[(naphthalen-1-yl)amino]-1,3-thiazole-4-carbonyl]-N-(propan-2-yl)piperidine-4-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000088
2-(alpha-naphthoyl) ethyltrimethylammonium iodide
Homo sapiens
pH 7.4, 23°C
0.0254
2-[[5-(furan-2-yl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-[4-(propan-2-yl)phenyl]ethan-1-one
Homo sapiens
pH 7.4, 37°C
0.0025
Hg2+
Electrophorus electricus
-
noncompetitive with respect to choline, IC50: 0.0004 mM, mixed type inhibition with respect to acetyl-CoA, IC50: 0.0025 mM, activity can be recovered using 2,3-dimercapto-propanol