2.3.1.6: choline O-acetyltransferase

This is an abbreviated version!
For detailed information about choline O-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.6

2.3.1.6

cholinergic

acetylcholine

nerve

acetylcholinesterase

hippocampus

forebrain

neurotransmitter

innervation

alzheimer

cortical

axon

medial

muscarinic

striatum

neurochemical

spinal

retrograde

maze

ventral

basalis

ganglion

neurotrophic

septal

ngf

diagonal

gabaergic

myenteric

interneurons

vacht

motoneuron

chat-positive

afferent

meynert

magnocellularis

presynaptic

varicosity

parasympathetic

non-cholinergic

preganglionic

benzilate

somata

calretinin

wga-hrp

intermediolateral

broca

analysis

amacrine

ache-positive

pharmacology

pedunculopontine

ibotenic

diagnostics

tegmentum

medicine

Reaction

Synonyms

acetyl CoA:choline-O-acetyltransferase, acetyl-CoA:choline-O-acetyltransferase, acetyltransferase, choline, cChAT, chAcT, ChAT, choline acetyl transferase, choline acetylase, choline acetyltransferase, choline-acetyltransferase, pChAT, peripheral type of choline acetyltransferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.6 choline O-acetyltransferase

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Results	in table
66	Activating Compound
37	AA Sequence
7	Application
1	CAS Registry Number
14	Cloned(Commentary)
5	Cofactor
3	Crystallization (Commentary)
1754	Disease/ Diagnostics
7	Expression
14	General Information
12	General Stability
5	IC50 Value
153	Inhibitors
7	Ki Value [mM]
77	KM Value [mM]
20	Localization
4	Metals/Ions
55	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
181	Organism
1	Oxidation Stability
1	Pathway
8	PDB ID
8	pH Optimum
5	Posttranslational Modification
17	Protein Variants
35	Purification (Commentary)
1	Reaction
1	Reaction Type
181	Reference
199	Source Tissue
28	Specific Activity [micromol/min/mg]
3	Storage Stability
130	Substrates and Products (Substrate)
24	Subunits
154	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]

Molecular Weight

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of the Enzyme Summary Page.

Molecular Weight on EC 2.3.1.6 - choline O-acetyltransferase

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106000

Bos taurus

largest aggregate, formation after ammonium sulfate fractionation, gel filtration

487307

120000 - 125000

Doryteuthis opalescens

peaks A, B1, gel filtration, gel electrophoresis

487311

128000

Catfish

gel filtration

487296

13000

Drosophila melanogaster

1 * 54000 + 1 * 13000, major form isolated, may be generated from monomeric form by limited proteolysis, SDS-PAGE

487292

140000

Catfish

gradient polyacrylamide electrophoresis

487296

200000

Doryteuthis opalescens

peak B2, gel filtration, gel electrophoresis

487311

30000 - 300000

Doryteuthis pealeii

self-association to large aggregates, gel filtration, sedimentation equilibrium

487299

34000

2 entries

37000

Doryteuthis pealeii

x * 37000 + x * 56000, SDS-PAGE, ultracentrifugation in presence of guanidine-HCl

487299

42000

Electrophorus electricus

2 * 42000, SDS-PAGE

49000

pChAT

54000

56000

x * 37000 + x * 56000, SDS-PAGE, ultracentrifugation in presence of guanidine-HCl

62000

65000

66000

66800

Schistocerca gregaria

gel filtration

67000

67000 - 69000

68000

68300

x * 68300, SDS-PAGE

68500

1 * 68500, SDS-PAGE

69000

71000

Caenorhabditis elegans

gel filtration

487291

72000

Bos taurus

x * 72000, isozyme CAT-A, x * 76000, isozyme CAT-B, SDS-PAGE

487283

76000

2 entries

80000

Electrophorus electricus

gel filtration

487327

81000

Octopus vulgaris

x * 81000, common type enzyme, SDS-PAGE

735874

96000

Rattus norvegicus

cChAT with GFP as fusion protein

660006

additional information

11 entries