2.3.1.6: choline O-acetyltransferase
This is an abbreviated version!
For detailed information about choline O-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.6
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2.3.1.6
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cholinergic
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acetylcholine
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nerve
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acetylcholinesterase
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hippocampus
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forebrain
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neurotransmitter
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innervation
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alzheimer
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cortical
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axon
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medial
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muscarinic
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striatum
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neurochemical
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spinal
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retrograde
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maze
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ventral
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basalis
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ganglion
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neurotrophic
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septal
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ngf
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diagonal
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gabaergic
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myenteric
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interneurons
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vacht
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motoneuron
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chat-positive
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afferent
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meynert
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magnocellularis
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presynaptic
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varicosity
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parasympathetic
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non-cholinergic
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preganglionic
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benzilate
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somata
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calretinin
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wga-hrp
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intermediolateral
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broca
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analysis
-
amacrine
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ache-positive
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pharmacology
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pedunculopontine
-
ibotenic
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diagnostics
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tegmentum
-
medicine
- 2.3.1.6
-
cholinergic
- acetylcholine
- nerve
- acetylcholinesterase
- hippocampus
- forebrain
-
neurotransmitter
-
innervation
- alzheimer
- cortical
- axon
-
medial
-
muscarinic
- striatum
-
neurochemical
- spinal
-
retrograde
-
maze
-
ventral
-
basalis
- ganglion
-
neurotrophic
- septal
- ngf
-
diagonal
-
gabaergic
- myenteric
-
interneurons
-
vacht
- motoneuron
-
chat-positive
-
afferent
- meynert
-
magnocellularis
-
presynaptic
-
varicosity
-
parasympathetic
-
non-cholinergic
-
preganglionic
- benzilate
-
somata
-
calretinin
-
wga-hrp
-
intermediolateral
- broca
- analysis
-
amacrine
-
ache-positive
- pharmacology
-
pedunculopontine
-
ibotenic
- diagnostics
- tegmentum
- medicine
Reaction
Synonyms
acetyl CoA:choline-O-acetyltransferase, acetyl-CoA:choline-O-acetyltransferase, acetyltransferase, choline, cChAT, chAcT, ChAT, choline acetyl transferase, choline acetylase, choline acetyltransferase, choline-acetyltransferase, pChAT, peripheral type of choline acetyltransferase
ECTree
2.3.1.6 choline O-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.6 - choline O-acetyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats, overview
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-
?
acetyl-CoA + carnitine
acetylcarnitine + CoA
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a mutant enzyme that incorporates four amino acid substitutions from wild type, shows a substantial increase in catalytic efficiency toward L-carnitine
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-
r
acetyl-CoA + choline
acetylcholine + CoA
-
-
-
-
?
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
-
-
-
-
?
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
-
-
-
-
?
acetyl-CoA + choline
acetylcholine + CoA
-
-
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
-
kinetic data indicate that choline acetyltransferase operates by forming an acetylated enzyme as an intermediate in the reversible reaction between acetyl-CoA and choline
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-
r
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine
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-
r
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine, deficiency in ChAT involved in several neurological and psychiatric disorders
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-
r
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
-
-
487277, 487278, 487285, 487288, 487295, 487297, 487301, 487305, 487310, 487316, 487318, 487322, 487323, 487324, 487329, 487330, 487331
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-
?
acetyl-CoA + choline
acetylcholine + CoA
-
-
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
-
synthesis of the neurotransmitter acetylcholine
-
-
r
acetyl-CoA + choline
acetylcholine + CoA
synthesis of the neurotransmitter acetylcholine that is essential for the development and neuronal activities of the cholinergic systems involved in many fundamental brain functions
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-
r
acetyl-CoA + choline
acetylcholine + CoA
synthesis of the neurotransmitter acetylcholine, mutations in ChAT causes congenital neuromuscular disorders
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-
r
acetyl-CoA + choline
CoA + O-acetylcholine
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-
acetylcholine is the primary parasympathetic neurotransmitter in the airways
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?
acetyl-CoA + choline
CoA + O-acetylcholine
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formation of acetylcholine in cholinergic neurons largely depends on both the levels of choline being transported into the cells from the extracellular space and the activity of ChAT, kinetics of choline uptake in the SK-N-SH cells
acetylcholine is the neurotransmitter used by cholinergic neurons
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?
acetyl-CoA + choline
CoA + O-acetylcholine
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choline taken up by OCTs or derived from the plasma membrane is also utilized for acetylcholine synthesis in both cholinergic neurons and nonneuronal cholinergic cells, such as lymphocytes
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-
?
acetyl-CoA + choline
CoA + O-acetylcholine
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-
-
-
?
