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2.3.1.61: dihydrolipoyllysine-residue succinyltransferase

This is an abbreviated version!
For detailed information about dihydrolipoyllysine-residue succinyltransferase, go to the full flat file.

Word Map on EC 2.3.1.61

Reaction

succinyl-CoA
+
enzyme N6-(dihydrolipoyl)lysine
=
CoA
+
enzyme N6-(S-succinyldihydrolipoyl)lysine

Synonyms

AceF, dihydrolipoamide acyltransacetylase, dihydrolipoamide S-succinyltransferase, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl succinyltransferase, dihydrolipolyl transsuccinylase, dihydrolipoyl succinyl transferase, dihydrolipoyl succinyltransferase, dihydrolipoyl transsuccinylase, DLST, DSCD, E2 component of alpha-ketoglutarate dehydrogenase complex, E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, E2o, KGD2, lipoate succinyltransferase, lipoic transsuccinylase, lipoyl transsuccinylase, OGDC-E2, SucB, succinyl-CoA:dihydrolipoate S-succinyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.61 dihydrolipoyllysine-residue succinyltransferase

Reference

Reference on EC 2.3.1.61 - dihydrolipoyllysine-residue succinyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Reed, L.J.; Cox, D.J.
Multienzyme complexes
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
1
213-240
1970
Bos taurus, Escherichia coli, Sus scrofa
-
Manually annotated by BRENDA team
De Kok, A.; Kornfeld, S.; Benziman, M.; Milner, Y.
Subunit composition and partial reactions of the 2-oxoglutarate dehydrogenase complex of Acetobacter xylinum
Eur. J. Biochem.
106
49-58
1980
Komagataeibacter xylinus
Manually annotated by BRENDA team
Pettit, F.H.; Hamilton, L.; Munk, P.; Namihira, G.; Eley, M.H.; Willms, C.R.; Reed, L.J.
alpha-Keto acid dehydrogenase complexes. XIX. Subunit structure of the Escherichia coli alpha-ketoglutarate dehydrogenase complex
J. Biol. Chem.
248
5282-5290
1973
Escherichia coli
Manually annotated by BRENDA team
Hein, S.; Steinbuechel, A.
Cloning and characterization of the Alcaligenes eutrophus 2-oxoglutarate dehydrogenase complex
FEMS Microbiol. Lett.
136
231-238
1996
Cupriavidus necator, Bacillus subtilis (P16263), Saccharomyces cerevisiae (P19262), Azotobacter vinelandii (P20708), Rattus norvegicus (Q01205)
Manually annotated by BRENDA team
Derosier, D.J.; Oliver, R.M.; Reed, L.J.
Crystallization and preliminary structural analysis of dihydrolipoyl transsuccinylase, the core of the 2-oxoglutarate dehydrogenase complex
Proc. Natl. Acad. Sci. USA
68
1135-1137
1971
Escherichia coli
Manually annotated by BRENDA team
Hall, E.R.; Weitzman, P.D.J.
A continuous spectrophotometric assay for the transacylase (E2) component of pyruvate and alpha-oxoglutarate dehydrogenase enzyme complexes
Anal. Biochem.
62
286-290
1974
Acinetobacter lwoffii
Manually annotated by BRENDA team
Tanaka, N.; Koike, K.; Otsuka, K.I.; Hamada, M.; Ogasahara, K.; Koike, M.
Mammalian alpha-keto acid dehydrogenase complexes. 8. Properties and subunit composition of the pig heart lipoate succinyltransferase
J. Biol. Chem.
249
191-198
1974
Sus scrofa
Manually annotated by BRENDA team
Angelides, K.J.; Hammes, G.G.
Structural and mechanistic studies of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli
Biochemistry
18
5531-5537
1979
Escherichia coli
Manually annotated by BRENDA team
White, R.H.; Bleile, D.M.; Reed, L.J.
Lipoic acid content of dihydrolipoyl transacylases determined by isotope dilution analysis
Biochem. Biophys. Res. Commun.
94
78-84
1980
Bos taurus, Escherichia coli
Manually annotated by BRENDA team
Robien, M.A.; Clore, G.M.; Omichinski, J.G.; Perham, R.N.; Appella, E.; Sakaguchi, K.; Gronenborn, A.M.
Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli
Biochemistry
31
3463-3471
1992
Escherichia coli
Manually annotated by BRENDA team
Nakano, K.; Takase, C.; Sakamoto, T.; Nakagawa, S.; Inazawa, J.; Ohta, S.; Matuda, S.
Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex
Eur. J. Biochem.
224
179-189
1994
Homo sapiens
Manually annotated by BRENDA team
Takase, C.; Nakano, K.; Ohta, S.; Nakagawa, S.; Matuda, S.
Different distribution of dihydrolipoamide succinyltransferase, dihydrolipoamide acetyltransferase and ATP synthase beta-subunit in monkey brain
In Vivo
10
495-502
1996
Macaca fuscata, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Matuda, S.; Kodama, J.; Goshi, N.; Takase, C.; Nakano, K.; Nakagawa, S.; Ohta, S.
A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle
Biochem. Biophys. Res. Commun.
241
151-156
1997
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Koike, K.; Ishibashi, H.; Koike, M.
Immunoreactivity of porcine heart dihydrolipoamide acetyl- and succinyl-transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera: characterization of the autoantigenic region and effects of enzymic delipoylation and relipoylation
Hepatology
27
1467-1474
1998
Bos taurus, Escherichia coli, Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Nguyen, S.V.; To, H.; Yamaguchi, T.; Fukushi, H.; Hirai, K.
Characterization of the Coxiella burnetii sucB gene encoding an immunogenic dihydrolipoamide succinyltransferase
Microbiol. Immunol.
43
743-749
1999
Escherichia coli, Coxiella burnetii (Q9RH46), Coxiella burnetii
Manually annotated by BRENDA team
Knapp, J.E.; Carroll, D.; Lawson, J.E.; Ernst, S.R.; Reed, L.J.; Hackert, M.L.
Expression, purification, and structural analysis of the trimeric form of the catalytic domain of the Escherichia coli dihydrolipoamide succinyltransferase
Protein Sci.
9
37-48
2000
Azotobacter vinelandii, Cupriavidus necator, Geobacillus stearothermophilus, Saccharomyces cerevisiae, Enterococcus faecalis, Haemophilus influenzae, Homo sapiens, Pseudomonas aeruginosa, Escherichia coli (P0AFG6), Escherichia coli, Corynebacterium glutamicum (Q8NNJ2)
Manually annotated by BRENDA team
Koike, K.; Suematsu, T.; Ehara, M.
Cloning, overexpression and mutagenesis of cDNA encoding dihydrolipoamide succinyltransferase component of the porcine 2-oxoglutarate dehydrogenase complex
Eur. J. Biochem.
267
3005-3016
2000
Azotobacter vinelandii, Bacillus subtilis, Bos taurus, Enterococcus faecalis, Escherichia coli, Homo sapiens, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa
Manually annotated by BRENDA team
Zygmunt, M.S.; Diaz, M.A.; Teixeira-Gomes, A.P.; Cloeckaert, A.
Cloning, nucleotide sequence, and expression of the Brucella melitensis sucB gene coding for an immunogenic dihydrolipoamide succinyltransferase homologous protein
Infect. Immun.
69
6537-6540
2001
Brucella abortus, Brucella anthropi, Phyllobacterium myrsinacearum, Escherichia coli (P0AFG6), Escherichia coli, Brucella melitensis (Q9L6H8), Brucella melitensis, Brucella melitensis 16M (Q9L6H8), Brucella abortus S19
Manually annotated by BRENDA team
Kanamori, T.; Nishimaki, K.; Asoh, S.; Ishibashi, Y.; Takata, I.; Kuwabara, T.; Taira, K.; Yamaguchi, H.; Sugihara, S.; Yamazaki, T.; Ihara, Y.; Nakano, K.; Matuda, S.; Ohta, S.
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain
EMBO J.
22
2913-2923
2003
Homo sapiens
Manually annotated by BRENDA team
Gilmore, R.D., Jr.; Carpio, A.M.; Kosoy, M.Y.; Gage, K.L.
Molecular characterization of the sucB gene encoding the immunogenic dihydrolipoamide succinyltransferase protein of Bartonella vinsonii subsp. berkhoffii and Bartonella quintana
Infect. Immun.
71
4818-4822
2003
Bartonella quintana (Q6FYD4), Bartonella quintana, Bartonella vinsonii (Q8GCY1)
Manually annotated by BRENDA team
MacDonald, M.J.; Husain, R.D.; Hoffmann-Benning, S.; Baker, T.R.
Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0
J. Biol. Chem.
279
27278-27285
2004
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Litwin, C.M.; Johnson, J.M.; Martins, T.B.
The Bartonella henselae sucB gene encodes a dihydrolipoamide succinyltransferase protein reactive with sera from patients with cat-scratch disease
J. Med. Microbiol.
53
1221-1227
2004
Bartonella henselae
Manually annotated by BRENDA team
Kabeya, H.; Maruyama, S.; Hirano, K.; Mikami, T.
Cloning and expression of Bartonella henselae sucB gene encoding an immunogenic dihydrolipoamide succinyltransferase homologous protein
Microbiol. Immunol.
47
571-576
2003
Bartonella henselae
Manually annotated by BRENDA team
Ohta, S.; Ohsawa, I.
Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimers disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification
J. Alzheimers Dis.
9
155-166
2006
Homo sapiens
Manually annotated by BRENDA team
Cisar, C.R.; Balog, J.M.; Anthony, N.B.; Donoghue, A.M.
Differential expression of cardiac muscle mitochondrial matrix proteins in broilers from ascites-resistant and susceptible lines
Poult. Sci.
84
704-708
2005
Gallus gallus
Manually annotated by BRENDA team
Dumont, M.; Ho, D.J.; Calingasan, N.Y.; Xu, H.; Gibson, G.; Beal, M.F.
Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition
Free Radic. Biol. Med.
47
1019-1027
2009
Homo sapiens
Manually annotated by BRENDA team
Yang, L.; Shi, Q.; Ho, D.J.; Starkov, A.A.; Wille, E.J.; Xu, H.; Chen, H.L.; Zhang, S.; Stack, C.M.; Calingasan, N.Y.; Gibson, G.E.; Beal, M.F.
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins
Neurobiol. Dis.
36
320-330
2009
Mus musculus
Manually annotated by BRENDA team
Hoffelder, M.; Raasch, K.; van Ooyen, J.; Eggeling, L.
The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF
J. Bacteriol.
192
5203-5211
2010
Corynebacterium glutamicum (Q8NNJ2)
Manually annotated by BRENDA team
Guo, H.; Madzak, C.; Du, G.; Zhou, J.
Mutagenesis of conserved active site residues of dihydrolipoamide succinyltransferase enhances the accumulation of alpha-ketoglutarate in Yarrowia lipolytica
Appl. Microbiol. Biotechnol.
100
649-659
2016
Yarrowia lipolytica (Q6C5L8), Yarrowia lipolytica, Yarrowia lipolytica E 150 (Q6C5L8)
Manually annotated by BRENDA team
Kessler, M.; Berger, I.M.; Just, S.; Rottbauer, W.
Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish
Basic Res. Cardiol.
110
14
2015
Danio rerio
Manually annotated by BRENDA team
Andi, B.; Soares, A.S.; Shi, W.; Fuchs, M.R.; McSweeney, S.; Liu, Q.
Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form a tale of a common protein crystallization contaminant
Acta Crystallogr. Sect. F
75
616-624
2019
Escherichia coli (P0AFG6), Escherichia coli
Manually annotated by BRENDA team
Guo, H.; Madzak, C.; Du, G.; Zhou, J.
Mutagenesis of conserved active site residues of dihydrolipoamide succinyltransferase enhances the accumulation of alpha-ketoglutarate in Yarrowia lipolytica
Appl. Microbiol. Biotechnol.
100
649-659
2016
Yarrowia lipolytica, Yarrowia lipolytica WSH-Z06
Manually annotated by BRENDA team
Heggermont, W.A.; Papageorgiou, A.P.; Quaegebeur, A.; Deckx, S.; Carai, P.; Verhesen, W.; Eelen, G.; Schoors, S.; van Leeuwen, R.; Alekseev, S.; Elzenaar, I.; Vinckier, S.; Pokreisz, P.; Walravens, A.S.; Gijsbers, R.; Van Den Haute, C.; Nickel, A.; Schroen, B.; van Bilsen, M.; Janssens, S.; Maack, C.; Pinto, Y.; Carmeliet, P.; Heymans, S.
Inhibition of microRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-induced cardiac hypertrophy and dysfunction
Circulation
136
747-761
2017
Mus musculus (Q9D2G2), Mus musculus
Manually annotated by BRENDA team
Chakraborty, J.; Nemeria, N.S.; Farinas, E.; Jordan, F.
Catalysis of transthiolacylation in the active centers of dihydrolipoamide acyltransacetylase components of 2-oxo acid dehydrogenase complexes
FEBS Open Bio
8
880-896
2018
Escherichia coli (P0AFG6), Escherichia coli
Manually annotated by BRENDA team
Chen, B.; Long, Q.; Zhao, Y.; Wu, Y.; Ge, S.; Wang, P.; Yang, C.G.; Chi, Y.; Song, B.; Yang, S.
Sulfone-based probes unraveled dihydrolipoamide S-succinyltransferase as an unprecedented target in phytopathogens
J. Agric. Food Chem.
67
6962-6969
2019
Xanthomonas citri, Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzae PXO99A, Xanthomonas citri 29-1
Manually annotated by BRENDA team