2.3.1.65: bile acid-CoA:amino acid N-acyltransferase

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For detailed information about bile acid-CoA:amino acid N-acyltransferase, go to the full flat file.

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Synonyms

acyltransferase, glycine-taurine N-, amino acid N-choloyltransferase, BAAT, BAATP1, BACAT, BAT, bile acid CoA: amino acid N-acyltransferase, bile acid CoA:amino acid N-acyltransferase, bile acid CoA:N-acyltransferase, bile acid coenzyme A-amino acid N-acyltransferase, bile acid coenzyme A: amino acid N-acyltransferase, bile acid coenzyme A:amino acid N-acyltransferase, bile acid-CoA:amino acid N acyltransferase, bile acid-CoA:amino acid N-acyltransferase, bile acid�coenzyme A:amino acid N-acyltransferase, glycine-taurine N-acyltransferase, hBAT, mBAT, rBAT

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.65 bile acid-CoA:amino acid N-acyltransferase

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4	Activating Compound
7	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
2	Disease/ Diagnostics
1	Expression
1	General Information
5	General Stability
23	Inhibitors
1	Ki Value [mM]
36	KM Value [mM]
13	Localization
11	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
29	Organism
6	Pathway
6	pH Optimum
2	pH Range
2	pH Stability
13	Protein Variants
12	Purification (Commentary)
4	Reaction
1	Reaction Type
29	Reference
30	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
97	Substrates and Products (Substrate)
4	Subunits
46	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.65 - bile acid-CoA:amino acid N-acyltransferase

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SYSTEMATIC NAME

IUBMB Comments

choloyl-CoA:glycine N-choloyltransferase

Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly [4]. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase [7]. Bile-acid---amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol [4]. This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate---CoA ligase.